{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T03:21:15Z","timestamp":1790306475657,"version":"4.1.0"},"reference-count":11,"publisher":"BMJ","issue":"12","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"unspecified","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"Fondo Europeo de Desarrollo Regional","doi-asserted-by":"crossref","award":["2017SGR00792"],"award-info":[{"award-number":["2017SGR00792"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Instituto de Salud Carlos III, Spanish Ministry of Health"},{"name":"Hospital Clinic"},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"crossref","award":["754550"],"award-info":[{"award-number":["754550"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003030","name":"AGAUR","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Hospital Cl\u00ednic"},{"name":"La Caixa","award":["CP042702"],"award-info":[{"award-number":["CP042702"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Immunother Cancer"],"accepted":{"date-parts":[[2021,11,14]]},"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:p>Multiple myeloma (MM) remains incurable despite the number of novel therapies that have become available in recent years. Occasionally, a patient with MM will develop an amyloid light-chain (AL) amyloidosis with organ dysfunction. Chimeric antigen receptor T-cell (CART) therapy has become a promising approach in treating hematological malignancies. Our institution has developed a second-generation B-cell maturation antigen (BCMA)\u2013CART which is currently being tested in a clinical trial for relapsed\/refractory MM.<\/jats:p>\n                  <jats:p>\n                    We present the first reported case, to our knowledge, of a patient with AL amyloidosis and renal involvement in the course of an MM, successfully treated with CART therapy targeting BCMA. The patient received a fractioned dose of 3\u00d710\n                    <jats:sup>6<\/jats:sup>\n                    \/kg BCMA\u2013CARTs after lymphodepletion. At 3 months from infusion, the patient had already obtained a deep hematological response with negative measurable residual disease by flow cytometry in the bone marrow. After 12 months, the patient remains in hematological stringent complete remission and has achieved an organ renal response with a decrease of 70% of proteinuria.\n                  <\/jats:p>\n                  <jats:p>This case suggests that concomitant AL amyloidosis in the setting of MM can benefit from CART therapy, even in patients in which predominant symptoms at the time of treating are caused by AL amyloidosis.<\/jats:p>","DOI":"10.1136\/jitc-2021-003783","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T11:25:22Z","timestamp":1638876322000},"page":"e003783","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":44,"title":["First report of CART treatment in AL amyloidosis and relapsed\/refractory multiple myeloma"],"prefix":"10.1136","volume":"9","clinical-trial-number":[{"clinical-trial-number":"nct04309981","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct04617925","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7921-5420","authenticated-orcid":false,"given":"Aina","family":"Oliver-Caldes","sequence":"first","affiliation":[{"name":"Hematology Department, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, Spain"},{"name":"Amyloidosis and Multiple Myeloma Unit, Hospital Clinic de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Hematology Department, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, Spain"},{"name":"Amyloidosis and Multiple Myeloma Unit, Hospital Clinic de Barcelona, Barcelona, Spain"},{"name":"Clinical Trial Unit, Hospital Clinic de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Espa\u00f1ol-Rego","sequence":"additional","affiliation":[{"name":"Immunology Department, Hospital Clinic de Barcelona, Barcelona, Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Cibeira","sequence":"additional","affiliation":[{"name":"Hematology Department, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, Spain"},{"name":"Amyloidosis and Multiple Myeloma Unit, Hospital Clinic de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4699-6862","authenticated-orcid":false,"given":"Valent\u00edn","family":"Ortiz-Maldonado","sequence":"additional","affiliation":[{"name":"Hematology Department, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis F","family":"Quintana","sequence":"additional","affiliation":[{"name":"Amyloidosis and Multiple Myeloma Unit, Hospital Clinic de Barcelona, Barcelona, Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, Spain"},{"name":"Glomerular Disease Unit (CSUR), Nephrology Department, Hospital Clinic de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Castillo","sequence":"additional","affiliation":[{"name":"Amyloidosis and Multiple Myeloma Unit, Hospital Clinic de Barcelona, Barcelona, Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, Spain"},{"name":"Pathology Department, Hospital Clinic de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Guijarro","sequence":"additional","affiliation":[{"name":"Hematopathology Unit, Hospital Clinic de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Tovar","sequence":"additional","affiliation":[{"name":"Hematology Department, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, Spain"},{"name":"Amyloidosis and Multiple Myeloma Unit, Hospital Clinic de Barcelona, Barcelona, Spain"},{"name":"Clinical Trial Unit, Hospital Clinic de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Montoro","sequence":"additional","affiliation":[{"name":"Hematology Department, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Benitez-Ribas","sequence":"additional","affiliation":[{"name":"Immunology Department, Hospital Clinic de Barcelona, Barcelona, Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6085-2745","authenticated-orcid":false,"given":"Alex","family":"Bataller","sequence":"additional","affiliation":[{"name":"Hematology Department, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E Azucena","family":"Gonz\u00e1lez-Navarro","sequence":"additional","affiliation":[{"name":"Immunology Department, Hospital Clinic de Barcelona, Barcelona, Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Cid","sequence":"additional","affiliation":[{"name":"Apheresis Unit, Hospital Clinic de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miquel","family":"Lozano","sequence":"additional","affiliation":[{"name":"Apheresis Unit, Hospital Clinic de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Perez-Amill","sequence":"additional","affiliation":[{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0612-2693","authenticated-orcid":false,"given":"Beatriz","family":"Martin-Antonio","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria, Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari-Pau","family":"Mena","sequence":"additional","affiliation":[{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David F","family":"Moreno","sequence":"additional","affiliation":[{"name":"Hematology Department, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, Spain"},{"name":"Amyloidosis and Multiple Myeloma Unit, Hospital Clinic de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Gerardo","family":"Rodr\u00edguez-Lobato","sequence":"additional","affiliation":[{"name":"Hematology Department, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, Spain"},{"name":"Amyloidosis and Multiple Myeloma Unit, Hospital Clinic de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep Maria","family":"Campistol","sequence":"additional","affiliation":[{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, 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