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Meanwhile, non-responders tended to be enriched for a novel Asian-specific transcriptomic subtype (Kaya_P2) with a high frequency of chromosome 16 deletions and upregulated cell cycle pathways. Strikingly, unlike other cancer types, we did not observe any association between T-cell populations and treatment response, but tumors from responders had a higher proportion of CXCL9\n                      <jats:sup>+<\/jats:sup>\n                      \/CXCR3\n                      <jats:sup>+<\/jats:sup>\n                      macrophages. Moreover, biomarkers discovered in previous immunotherapy trials were not predictive in the current cohort, suggesting a distinctive molecular landscape associated with differential responses to the combination therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study unraveled extensive molecular changes underlying distinctive responses to the novel treatment and pinpointed new directions for harnessing combination therapy in patients with advanced HCC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jitc-2023-007106","type":"journal-article","created":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T13:17:39Z","timestamp":1692191859000},"page":"e007106","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Multimodal molecular landscape of response to Y90-resin 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