{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:00:10Z","timestamp":1787508010579,"version":"build-2736575974"},"reference-count":64,"publisher":"BMJ","issue":"8","license":[{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"unspecified","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2018YFA0900900"],"award-info":[{"award-number":["2018YFA0900900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M732974"],"award-info":[{"award-number":["2023M732974"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Qing Lan Project of Jiangsu Province, Research Foundation of Xuzhou Medical University","award":["D2022013"],"award-info":[{"award-number":["D2022013"]}]},{"name":"Xuzhou Municipal Science and Technology Project","award":["KC23038"],"award-info":[{"award-number":["KC23038"]}]},{"DOI":"10.13039\/501100010023","name":"Natural Science Research of Jiangsu Higher Education Institutions of China","doi-asserted-by":"publisher","award":["22KJA320004"],"award-info":[{"award-number":["22KJA320004"]}],"id":[{"id":"10.13039\/501100010023","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072814"],"award-info":[{"award-number":["82072814"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Immunother Cancer"],"accepted":{"date-parts":[[2024,8,12]]},"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Targeting kinases presents a potential strategy for treating solid tumors; however, the therapeutic potential of vaccines targeting kinases remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adenovirus (Ad) vaccines encoding Aurora kinase A (AURKA) or cyclin-dependent kinase 7 (CDK7) were developed, and their therapeutic potentials were investigated by various methods including western blot, flow cytometry, cytotoxic T lymphocyte assay, and enzyme-linked immunospot (ELISpot), in mouse and humanized solid tumor models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Co-immunization with Ad-AURKA\/CDK7 effectively prevented subcutaneous tumor growth in the Renca, RM-1, MC38, and Hepa1-6 tumor models. In therapeutic tumor models, Ad-AURKA\/CDK7 treatment impeded tumor growth and increased immune cell infiltration. Administration of Ad-AURKA\/CDK7 promoted the induction and maturation of dendritic cell subsets and augmented multifunctional CD8\n                      <jats:sup>+<\/jats:sup>\n                      T-cell antitumor immunity. Furthermore, the vaccine induced a long-lasting antitumor effect by promoting the generation of memory CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells. Tumor recovery on CD8\n                      <jats:sup>+<\/jats:sup>\n                      T-cell depletion underscored the indispensable role of these cells in the observed therapeutic effects. The potent efficacy of the Ad-AURKA\/CDK7 vaccine was consistently demonstrated in lung metastasis, orthotopic, and humanized tumor models by inducing multifunctional CD8\n                      <jats:sup>+<\/jats:sup>\n                      T-cell antitumor immune responses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings illustrate that the Ad-AURKA\/CDK7 vaccine targeting dual kinases AURKA and CDK7 emerges as a promising and effective therapeutic approach for the treatment of solid tumors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jitc-2024-009869","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:45:46Z","timestamp":1724892346000},"page":"e009869","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Adenovirus vaccine targeting kinases induces potent antitumor immunity in solid tumors"],"prefix":"10.1136","volume":"12","author":[{"given":"Fei","family":"Zhu","sequence":"first","affiliation":[{"name":"Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China"},{"name":"Center of Clinical Oncology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China"},{"name":"Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Xuzhou Medical University, Xuzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Lu","sequence":"additional","affiliation":[{"name":"Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China"},{"name":"Center of Clinical Oncology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China"},{"name":"Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Xuzhou Medical University, Xuzhou, Jiangsu, 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