{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:11:14Z","timestamp":1791573074191,"version":"4.3.4"},"reference-count":10,"publisher":"BMJ","issue":"10","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"unspecified","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Immunother Cancer"],"accepted":{"date-parts":[[2025,8,26]]},"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:p>\n                    Targeted resistance to immune checkpoint therapy remains a clinical challenge, and a recent study reported by Xie\n                    <jats:italic>et al<\/jats:italic>\n                    provides novel insights into how RNA acetylation, particularly N4-acetylcytidine (ac\n                    <jats:sup>4<\/jats:sup>\n                    C), plays a pivotal role in shaping the tumor immune microenvironment in nasopharyngeal carcinoma (NPC). Through elucidation of the NAT10\/DDX5\/high mobility group box 1 axis, the authors demonstrate that enhanced ac\n                    <jats:sup>4<\/jats:sup>\n                    C modification suppresses CD4\n                    <jats:sup>+<\/jats:sup>\n                    and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T-cell functionality, thereby facilitating tumor immune evasion and the resistance to anti-programmed cell death protein-1 therapy. This commentary evaluates the significance of these findings within the broader context of epitranscriptomic regulation research in oncology, identifies critical knowledge gaps regarding the equilibrium between immunosuppression and immune activation, and examines the therapeutic potential of NAT10 inhibition as a potential combinatorial approach in cancer immunotherapy. This work advances our understanding of how post-transcriptional RNA modifications influence tumor-immune interactions, establishing a conceptual framework for future investigations aimed at optimizing immunotherapeutic approaches in NPC and potentially other malignancies.\n                  <\/jats:p>","DOI":"10.1136\/jitc-2025-012254","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T07:55:22Z","timestamp":1761033322000},"page":"e012254","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Targeting oncogenic acetyltransferase NAT10 to overcome anti-PD-1 resistance in nasopharyngeal carcinoma"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6790-3402","authenticated-orcid":false,"given":"Yue","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of General, Visceral, Thoracic and Transplantation Surgery, Uniklinik K\u00f6ln, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,10,20]]},"reference":[{"key":"2025111301352513000_13.10.e012254.1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0374-x"},{"key":"2025111301352513000_13.10.e012254.2","first-page":"203","article-title":"Reduced-volume radiotherapy versus conventional-volume radiotherapy after induction chemotherapy in nasopharyngeal carcinoma: An open-label, noninferiority, multicenter, randomized phase 3 trial","volume":"75","author":"Tang","year":"2025","journal-title":"CA Cancer J Clin"},{"key":"2025111301352513000_13.10.e012254.3","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.675731","article-title":"High Mobility Group Box 1 (HMGB1) Induces Toll-Like Receptor 4-Mediated Production of the Immunosuppressive Protein Galectin-9 in Human Cancer Cells","volume":"12","author":"Teo Hansen Seln\u00f8","year":"2021","journal-title":"Front Immunol"},{"key":"2025111301352513000_13.10.e012254.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.04.019"},{"key":"2025111301352513000_13.10.e012254.5","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/s41590-025-02100-2","article-title":"A critical role of N4-acetylation of cytidine in mRNA by NAT10 in T cell expansion and antiviral immunity","volume":"26","author":"Sun","year":"2025","journal-title":"Nat Immunol"},{"key":"2025111301352513000_13.10.e012254.6","doi-asserted-by":"crossref","DOI":"10.1186\/s13046-024-03200-x","article-title":"NAT10\/ac4C\/JunB facilitates TNBC malignant progression and immunosuppression by driving glycolysis addiction","volume":"43","author":"Li","year":"2024","journal-title":"J Exp Clin Cancer Res"},{"key":"2025111301352513000_13.10.e012254.7","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202302705","article-title":"NAT10\/ac4C\/FOXP1 Promotes Malignant Progression and Facilitates Immunosuppression by Reprogramming Glycolytic Metabolism in Cervical Cancer","volume":"10","author":"Chen","year":"2023","journal-title":"Adv Sci (Weinh)"},{"key":"2025111301352513000_13.10.e012254.8","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2024-010301","article-title":"Acetyltransferase NAT10 inhibits T-cell immunity and promotes nasopharyngeal carcinoma progression through DDX5\/HMGB1 axis","volume":"13","author":"Xie","year":"2025","journal-title":"J Immunother Cancer"},{"key":"2025111301352513000_13.10.e012254.9","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202410263","article-title":"NAT10 Promotes Gastric Cancer Liver Metastasis by Modulation of M2 Macrophage Polarization and Metastatic Tumor Cell Hepatic Adhesion","volume":"12","author":"Chen","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"2025111301352513000_13.10.e012254.10","doi-asserted-by":"crossref","DOI":"10.1186\/s12935-021-02124-2","article-title":"NAT10 as a potential prognostic biomarker and therapeutic target for HNSCC","volume":"21","author":"Tao","year":"2021","journal-title":"Cancer Cell Int"}],"container-title":["Journal for ImmunoTherapy of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jitc-2025-012254","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T09:36:00Z","timestamp":1763026560000},"score":1,"resource":{"primary":{"URL":"https:\/\/jitc.bmj.com\/lookup\/doi\/10.1136\/jitc-2025-012254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":10,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10,20]]},"published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1136\/jitc-2025-012254"],"URL":"https:\/\/doi.org\/10.1136\/jitc-2025-012254","relation":{},"ISSN":["2051-1426"],"issn-type":[{"value":"2051-1426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]}}}