{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:21:40Z","timestamp":1788351700033,"version":"build-2803163510"},"reference-count":65,"publisher":"BMJ","issue":"6","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"unspecified","delay-in-days":17,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"High Quality Development of Medical Innovation Project in Xiamen","award":["2024GZL-CX29"],"award-info":[{"award-number":["2024GZL-CX29"]}]},{"name":"Natural Science Foundation Program of Fujian Province","award":["2023J011598"],"award-info":[{"award-number":["2023J011598"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970460"],"award-info":[{"award-number":["81970460"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Immunother Cancer"],"accepted":{"date-parts":[[2026,5,22]]},"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic inflammation is a well-established driver of colorectal cancer (CRC), with the resulting inflammatory microenvironment facilitating tumor initiation and progression. The integrin CD11b\/CD18, a leukocyte-specific heterodimeric adhesion receptor, mediates critical immunoregulatory functions during inflammatory responses. However, the roles and mechanisms of CD11b\/CD18 in colitis-associated colorectal cancer (CAC) remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To investigate the impact of CD11b\/CD18 deficiency on colorectal carcinogenesis, an azoxymethane\/dextran sodium sulfate-induced CAC model was established with CD11b and CD18 single-knockout and double-knockout mice. The tumor immune microenvironment was characterized using multicolor flow cytometry. Transcriptomic changes in tumor-associated neutrophils (TANs) and macrophages (TAMs) on CD11b\/CD18 ablation were profiled by RNA sequencing. Functional crosstalk between TANs and TAMs was assessed via co-culture experiments. The direct role of CD11b\/CD18 in TAM polarization and antitumor activity was evaluated using in vitro agonist assays, and the involvement of the extracellular signal-regulated kinase (ERK)\/signal transducer and activator of transcription 3 (STAT3) axis was validated with pathway-specific inhibitors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Bioinformatics analysis revealed significant downregulation of\n                      <jats:italic>ITGAM<\/jats:italic>\n                      (CD11b) and\n                      <jats:italic>ITGB2<\/jats:italic>\n                      (CD18) expression in CRC tissues. In the CAC model, CD11b and CD18 exhibited non-redundant and cooperative functions, and double deficiency significantly exacerbated tumor progression, with increased STAT3 phosphorylation and reduced yes-associated protein phosphorylation. Flow cytometric analysis identified neutrophils as the predominant CD11b\n                      <jats:sup>+<\/jats:sup>\n                      CD18\n                      <jats:sup>+<\/jats:sup>\n                      population within the tumor microenvironment (TME). Mechanistically, CD11b\/CD18 deficiency promoted TME remodeling, including protumor skewing of TANs and TAMs, with TAM polarization mediated partly by TAN-TAM crosstalk. Beyond this indirect mechanism, direct activation of CD11b\/CD18 in TAMs attenuated the immunosuppressive properties and enhanced their tumoricidal activity. At the molecular level, CD11b\/CD18 deficiency activated janus kinase (JAK)-STAT and mitogen-activated protein kinase pathways in TAMs, whereas CD11b\/CD18 activation effectively suppressed ERK1\/2 and STAT3 signaling. Combined inhibition of ERK1\/2 and STAT3 reversed M2 polarization and restored TAM-mediated tumor killing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings establish that integrin CD11b\/CD18 orchestrates antitumor immunity by modulating the TME, particularly through direct TAM reprogramming and indirect TAN-TAM crosstalk, highlighting its potential as an immunotherapeutic target for CAC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jitc-2025-014026","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T10:55:22Z","timestamp":1781780122000},"page":"e014026","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Integrin CD11b\/CD18 reprograms macrophage polarization by suppressing ERK\/STAT3 signaling to enhance antitumor immunity in colitis-associated colorectal cancer"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9270-7100","authenticated-orcid":false,"given":"Ying","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China"},{"name":"Department of Gastroenterology, Wenzhou Central Hospital, Affiliated to Wenzhou Medical University, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3076-3647","authenticated-orcid":false,"given":"Yuan-Kun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Mi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0399-1279","authenticated-orcid":false,"given":"Xian-Ling","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Hui","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Shen","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai-Ying","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Dong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Ni","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-Jing","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8076-5632","authenticated-orcid":false,"given":"Zhen-Yu","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1106-5304","authenticated-orcid":false,"given":"Bayasi","family":"Guleng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China"},{"name":"Cancer Research Center, Department of Digestive Disease and Institute of Microbial Ecology, School of Medicine, Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"2026090205002098000_14.6.e014026.1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21871"},{"key":"2026090205002098000_14.6.e014026.2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.4.526"},{"key":"2026090205002098000_14.6.e014026.3","first-page":"53","article-title":"Current management of inflammatory bowel disease and colorectal cancer","volume":"4","author":"Mattar","year":"2011","journal-title":"Gastrointest Cancer Res"},{"key":"2026090205002098000_14.6.e014026.4","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.10.035"},{"key":"2026090205002098000_14.6.e014026.5","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1186\/s13578-023-01139-8","article-title":"Colitis-associated carcinogenesis: crosstalk between tumors, immune cells and gut microbiota","volume":"13","author":"Li","year":"2023","journal-title":"Cell Biosci"},{"key":"2026090205002098000_14.6.e014026.6","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-022-10028-4"},{"key":"2026090205002098000_14.6.e014026.7","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/s41577-021-00534-x","article-title":"The inflammatory pathogenesis of colorectal cancer","volume":"21","author":"Schmitt","year":"2021","journal-title":"Nat Rev Immunol"},{"key":"2026090205002098000_14.6.e014026.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.02.016"},{"key":"2026090205002098000_14.6.e014026.9","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.64077"},{"key":"2026090205002098000_14.6.e014026.10","doi-asserted-by":"crossref","first-page":"215816","DOI":"10.1016\/j.canlet.2022.215816","article-title":"Colorectal cancer immunotherapy-Recent progress and future directions","volume":"545","author":"Zhao","year":"2022","journal-title":"Cancer Lett"},{"key":"2026090205002098000_14.6.e014026.11","doi-asserted-by":"crossref","first-page":"103669","DOI":"10.1016\/j.drudis.2023.103669","article-title":"Immunotherapy and immunoevasion of colorectal cancer","volume":"28","author":"Al Zein","year":"2023","journal-title":"Drug Discov Today"},{"key":"2026090205002098000_14.6.e014026.12","doi-asserted-by":"crossref","DOI":"10.1186\/s13045-022-01335-y","article-title":"Emerging strategies in targeting tumor-resident myeloid cells for cancer immunotherapy","volume":"15","author":"Wang","year":"2022","journal-title":"J Hematol Oncol"},{"key":"2026090205002098000_14.6.e014026.13","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/s43018-023-00691-z","article-title":"Sirp\u03b1 on tumor-associated myeloid cells restrains antitumor immunity in colorectal cancer independent of its interaction with CD47","volume":"5","author":"Huang","year":"2024","journal-title":"Nat Cancer"},{"key":"2026090205002098000_14.6.e014026.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.02.050"},{"key":"2026090205002098000_14.6.e014026.15","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12192"},{"key":"2026090205002098000_14.6.e014026.16","doi-asserted-by":"publisher","DOI":"10.1038\/nri1733"},{"key":"2026090205002098000_14.6.e014026.17","doi-asserted-by":"publisher","DOI":"10.1002\/kjm2.12405"},{"key":"2026090205002098000_14.6.e014026.18","doi-asserted-by":"crossref","first-page":"1537631","DOI":"10.3389\/fimmu.2025.1537631","article-title":"The role of intestinal macrophage polarization in colitis-associated colon cancer","volume":"16","author":"Deng","year":"2025","journal-title":"Front Immunol"},{"key":"2026090205002098000_14.6.e014026.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2022.07.004"},{"key":"2026090205002098000_14.6.e014026.20","doi-asserted-by":"crossref","first-page":"109569","DOI":"10.1016\/j.intimp.2022.109569","article-title":"Tumor-associated macrophages employ immunoediting mechanisms in colorectal tumor progression: Current research in Macrophage repolarization immunotherapy","volume":"116","author":"Cheruku","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"2026090205002098000_14.6.e014026.21","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-2073"},{"key":"2026090205002098000_14.6.e014026.22","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-2076"},{"key":"2026090205002098000_14.6.e014026.23","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28536"},{"key":"2026090205002098000_14.6.e014026.24","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-025-02228-7","article-title":"Bidirectional role of neutrophils in tumor development","volume":"24","author":"Luyang","year":"2025","journal-title":"Mol Cancer"},{"key":"2026090205002098000_14.6.e014026.25","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26010006","article-title":"Neutrophil and Colorectal Cancer","volume":"26","author":"Masui","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2026090205002098000_14.6.e014026.26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.06.017"},{"key":"2026090205002098000_14.6.e014026.27","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-136895"},{"key":"2026090205002098000_14.6.e014026.28","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14645"},{"key":"2026090205002098000_14.6.e014026.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2024.03.031"},{"key":"2026090205002098000_14.6.e014026.30","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.4MIR0220-574RR"},{"key":"2026090205002098000_14.6.e014026.31","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.106.6.2153"},{"key":"2026090205002098000_14.6.e014026.32","first-page":"161","article-title":"Leukocyte CD11\/CD18 integrins: biological and clinical relevance","volume":"80","author":"Mazzone","year":"1995","journal-title":"Haematologica"},{"key":"2026090205002098000_14.6.e014026.33","doi-asserted-by":"publisher","DOI":"10.1007\/BF00919970"},{"key":"2026090205002098000_14.6.e014026.34","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V75.5.1037.1037"},{"key":"2026090205002098000_14.6.e014026.35","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80278-2"},{"key":"2026090205002098000_14.6.e014026.36","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12373"},{"key":"2026090205002098000_14.6.e014026.37","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.167151","article-title":"Sialylation regulates neutrophil transepithelial migration, CD11b\/CD18 activation, and intestinal mucosal inflammatory function","volume":"8","author":"Azcutia","year":"2023","journal-title":"JCI Insight"},{"key":"2026090205002098000_14.6.e014026.38","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13899","article-title":"Prophylactic orthosteric inhibition of leukocyte integrin CD11b\/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeys","volume":"8","author":"Dehnadi","year":"2017","journal-title":"Nat Commun"},{"key":"2026090205002098000_14.6.e014026.39","first-page":"II372","article-title":"Inhibition of neutrophil adherence improves postischemic ventricular performance of the neonatal heart","volume":"88","author":"Wilson","year":"1993","journal-title":"Circulation"},{"key":"2026090205002098000_14.6.e014026.40","doi-asserted-by":"publisher","DOI":"10.1016\/0270-9139(93)90169-N"},{"key":"2026090205002098000_14.6.e014026.41","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2001811","article-title":"Small molecule-mediated activation of the integrin CD11b\/CD18 reduces inflammatory disease","volume":"4","author":"Maiguel","year":"2011","journal-title":"Sci Signal"},{"key":"2026090205002098000_14.6.e014026.42","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aau9240","article-title":"Agonism of CD11b reprograms innate immunity to sensitize pancreatic cancer to immunotherapies","volume":"11","author":"Panni","year":"2019","journal-title":"Sci Transl Med"},{"key":"2026090205002098000_14.6.e014026.43","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3818"},{"key":"2026090205002098000_14.6.e014026.44","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00005.2014"},{"key":"2026090205002098000_14.6.e014026.45","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.abj8393","article-title":"STAT3-YAP\/TAZ signaling in endothelial cells promotes tumor angiogenesis","volume":"14","author":"Shen","year":"2021","journal-title":"Sci Signal"},{"key":"2026090205002098000_14.6.e014026.46","doi-asserted-by":"crossref","first-page":"5471","DOI":"10.2147\/JIR.S377077","article-title":"YAP Activates STAT3 Signalling to Promote Colonic Epithelial Cell Proliferation in DSS-Induced Colitis and Colitis Associated Cancer","volume":"15","author":"Deng","year":"2022","journal-title":"J Inflamm Res"},{"key":"2026090205002098000_14.6.e014026.47","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.708770","article-title":"Transcriptional Profiling and Functional Analysis of N1\/N2 Neutrophils Reveal an Immunomodulatory Effect of S100A9-Blockade on the Pro-Inflammatory N1 Subpopulation","volume":"12","author":"Mihaila","year":"2021","journal-title":"Front Immunol"},{"key":"2026090205002098000_14.6.e014026.48","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202406865","article-title":"Integrin \u03b28 Facilitates Macrophage Infiltration and Polarization by Regulating CCL5 to Promote LUAD Progression","volume":"12","author":"Song","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"2026090205002098000_14.6.e014026.49","doi-asserted-by":"crossref","unstructured":"Zhu Y-Y , Zhao Y-C , Chen C , et al . CCL5 secreted by luminal B breast cancer cells induces polarization of M2 macrophages through activation of MEK\/STAT3 signaling pathway via CCR5. Gene 2022;812. doi:10.1016\/j.gene.2021.146100","DOI":"10.1016\/j.gene.2021.146100"},{"key":"2026090205002098000_14.6.e014026.50","doi-asserted-by":"crossref","DOI":"10.1186\/s13045-020-01027-5","article-title":"Regulation of PD-L1 expression in the tumor microenvironment","volume":"14","author":"Yi","year":"2021","journal-title":"J Hematol Oncol"},{"key":"2026090205002098000_14.6.e014026.51","doi-asserted-by":"publisher","DOI":"10.1172\/JCI96061"},{"key":"2026090205002098000_14.6.e014026.52","doi-asserted-by":"crossref","DOI":"10.1186\/s13046-022-02499-8","article-title":"Gastric cancer-derived exosomal miR-519a-3p promotes liver metastasis by inducing intrahepatic M2-like macrophage-mediated angiogenesis","volume":"41","author":"Qiu","year":"2022","journal-title":"J Exp Clin Cancer Res"},{"key":"2026090205002098000_14.6.e014026.53","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1549564","article-title":"The role of Fusobacterium nucleatum in macrophage M2 polarization and NF-\u03baB pathway activation in colorectal cancer","volume":"16","author":"Zheng","year":"2025","journal-title":"Front Immunol"},{"key":"2026090205002098000_14.6.e014026.54","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-024-02888-5","article-title":"Hypoxic glioma-derived exosomal miR-25-3p promotes macrophage M2 polarization by activating the PI3K-AKT-mTOR signaling pathway","volume":"22","author":"Xue","year":"2024","journal-title":"J Nanobiotechnology"},{"key":"2026090205002098000_14.6.e014026.55","doi-asserted-by":"crossref","DOI":"10.1038\/srep15948","article-title":"CD11b deficiency suppresses intestinal tumor growth by reducing myeloid cell recruitment","volume":"5","author":"Zhang","year":"2015","journal-title":"Sci Rep"},{"key":"2026090205002098000_14.6.e014026.56","doi-asserted-by":"publisher","DOI":"10.1002\/path.4645"},{"key":"2026090205002098000_14.6.e014026.57","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.16159","article-title":"Murine models of colorectal cancer: the azoxymethane (AOM)\/dextran sulfate sodium (DSS) model of colitis-associated cancer","volume":"11","author":"Dzhalilova","year":"2023","journal-title":"PeerJ"},{"key":"2026090205002098000_14.6.e014026.58","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119293"},{"key":"2026090205002098000_14.6.e014026.59","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0083395","article-title":"The MEK-ERK pathway is necessary for serine phosphorylation of mitochondrial STAT3 and Ras-mediated transformation","volume":"8","author":"Gough","year":"2013","journal-title":"PLoS One"},{"key":"2026090205002098000_14.6.e014026.60","doi-asserted-by":"crossref","DOI":"10.1186\/s12931-023-02605-0","article-title":"Alpha-defensins inhibit ERK\/STAT3 signaling during monocyte-macrophage differentiation and impede macrophage function","volume":"24","author":"Lee","year":"2023","journal-title":"Respir Res"},{"key":"2026090205002098000_14.6.e014026.61","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2018.1444305"},{"key":"2026090205002098000_14.6.e014026.62","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M406968200"},{"key":"2026090205002098000_14.6.e014026.63","doi-asserted-by":"crossref","DOI":"10.4110\/in.2021.21.e13","article-title":"CD11b Deficiency Exacerbates Methicillin-Resistant Staphylococcus aureus-Induced Sepsis by Upregulating Inflammatory Responses of Macrophages","volume":"21","author":"Sim","year":"2021","journal-title":"Immune Netw"},{"key":"2026090205002098000_14.6.e014026.64","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.1.297"},{"key":"2026090205002098000_14.6.e014026.65","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-07387-4","article-title":"Integrin CD11b activation drives anti-tumor innate immunity","volume":"9","author":"Schmid","year":"2018","journal-title":"Nat Commun"}],"container-title":["Journal for ImmunoTherapy of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jitc-2025-014026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:00:36Z","timestamp":1788350436000},"score":1,"resource":{"primary":{"URL":"https:\/\/jitc.bmj.com\/lookup\/doi\/10.1136\/jitc-2025-014026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":65,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6,18]]},"published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1136\/jitc-2025-014026"],"URL":"https:\/\/doi.org\/10.1136\/jitc-2025-014026","relation":{},"ISSN":["2051-1426"],"issn-type":[{"value":"2051-1426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]}}}