{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:28:28Z","timestamp":1792787308451,"version":"4.5.0"},"reference-count":55,"publisher":"BMJ","issue":"9","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"unspecified","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation","award":["2024ZY01003"],"award-info":[{"award-number":["2024ZY01003"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32571083"],"award-info":[{"award-number":["32571083"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Clinical Medicine Plus X-Scholar Project of the Second Affiliated Hospital of Wenzhou Medical University","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"https:\/\/ror.org\/011b9vp56","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Major Scientific and Technological Innovation Project of Wenzhou Science and Technology Bureau","award":["ZY2022015"],"award-info":[{"award-number":["ZY2022015"]}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFA0918601"],"award-info":[{"award-number":["2024YFA0918601"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ23H160017"],"award-info":[{"award-number":["LQ23H160017"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Immunother Cancer"],"accepted":{"date-parts":[[2026,8,17]]},"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A substantial amount of research has been dedicated to the mechanisms by which tumor cells evade immune system recognition and manipulate the immune microenvironment to facilitate immune escape. Recent studies have shown that viruses and tumors can protect themselves from immune cytotoxicity by remodeling the actin cytoskeleton. However, cytoskeleton-mediated immune resistance and the specific cytoskeleton-related proteins involved require further research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Single-cell RNA sequencing was used to identify cytoskeleton-related genes associated with the response to anti-programmed cell death protein 1 (PD-1) therapy across four digestive tumors. Immunohistochemistry was used to detect LASP1 expression in gastric cancer and analyze its prognostic value for survival and anti-PD-1 response. The impact of LASP1 deficiency on tumor response to anti-PD-1 treatment and cytotoxic lymphocyte-mediated lysis was determined in vivo and in vitro. Live-cell imaging was used to compare actin cytoskeletal dynamics at the immunological synapse between LASP1-deficient and mock tumor cells. Molecular mechanisms underlying LASP1-mediated immune-resistance were dissected using co-immunoprecipitation, immunofluorescence, domain deletion complementation, and Laurdan staining.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The deficiency of LASP1 in gastric cancer affected the sensitivity of tumor cells to immunotherapy and induced cytotoxic lymphocytes exhaustion. LASP1 may act as a scaffold protein to regulate the Arp2\/3 complex and remodel the cytoskeleton at the immunological synapses. LASP1 deficiency in tumor cells impairs lytic immunological synapse function by disrupting cytoskeletal dynamics-mediated cell membrane lipid organization at the immunological synapse. Finally, simvastatin combined with anti-PD-1 therapy reversed immunotherapy resistance in LASP1-deficient tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The deficiency of LASP1 in tumors mediates immunological synapse dysfunction by affecting cytoskeletal dynamics-mediated cell membrane lipid organization, thus enabling tumors to protect themselves from immune cytotoxicity and immunotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jitc-2025-014475","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:05:13Z","timestamp":1788361513000},"page":"e014475","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["LIM and SH3 protein 1 deficiency confers resistance to cytotoxic lymphocyte-mediated lysis and immunotherapy in gastric cancer by disrupting cytoskeleton dynamics"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6144-4109","authenticated-orcid":false,"given":"Teming","family":"Zhang","sequence":"first","affiliation":[{"name":"NHC Key Laboratory of Clinical Nutrition and Intervention, Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, Department of Oncology, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China"},{"name":"Wenzhou Key Laboratory of Cancer-related Pathogens and Immunity, Zhejiang International Cooperation Base for Tumor-Associated Pathogen and Host Interaction, Institute of Molecular Virology and Immunology, Department of Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China"},{"name":"International Science and Technology Cooperation Base for Tumor Translational Research of Zhejiang Province, Department of Gastrointestinal Surgery, Department of Gastroenterology, The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Sun","sequence":"additional","affiliation":[{"name":"Wenzhou Key Laboratory of Cancer-related Pathogens and Immunity, Zhejiang International Cooperation Base for Tumor-Associated Pathogen and Host Interaction, Institute of Molecular Virology and Immunology, Department of Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Chen","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Clinical Nutrition and Intervention, Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, Department of Oncology, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China"},{"name":"Wenzhou Key Laboratory of Cancer-related Pathogens and Immunity, Zhejiang International Cooperation Base for Tumor-Associated Pathogen and Host Interaction, Institute of Molecular Virology and Immunology, Department of Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China"},{"name":"International Science and Technology Cooperation Base for Tumor Translational Research of Zhejiang Province, Department of Gastrointestinal Surgery, Department of Gastroenterology, The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwei","family":"Zheng","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Clinical Nutrition and Intervention, Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, Department of Oncology, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyun","family":"Chang","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Clinical Nutrition and Intervention, Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, Department of Oncology, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhen","family":"Xiang","sequence":"additional","affiliation":[{"name":"Wenzhou Key Laboratory of Cancer-related Pathogens and Immunity, Zhejiang International Cooperation Base for Tumor-Associated Pathogen and Host Interaction, Institute of Molecular Virology and Immunology, Department of Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiongying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoliang","family":"Li","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Clinical Nutrition and Intervention, Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, Department of Oncology, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China"},{"name":"International Science and Technology Cooperation Base for Tumor Translational Research of Zhejiang Province, Department of Gastrointestinal Surgery, Department of Gastroenterology, The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangkai","family":"Xie","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Clinical Nutrition and Intervention, Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, Department of Oncology, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China"},{"name":"Wenzhou Key Laboratory of Cancer-related Pathogens and Immunity, Zhejiang International Cooperation Base for Tumor-Associated Pathogen and Host Interaction, Institute of Molecular Virology and Immunology, Department of Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoyi","family":"Xu","sequence":"additional","affiliation":[{"name":"Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenchen","family":"Mao","sequence":"additional","affiliation":[{"name":"Wenzhou Key Laboratory of Cancer-related Pathogens and Immunity, Zhejiang International Cooperation Base for Tumor-Associated Pathogen and Host Interaction, Institute of Molecular Virology and Immunology, Department of Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingdong","family":"Lu","sequence":"additional","affiliation":[{"name":"International Science and Technology Cooperation Base for Tumor Translational Research of Zhejiang Province, Department of Gastrointestinal Surgery, Department of Gastroenterology, The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhai","family":"Cai","sequence":"additional","affiliation":[{"name":"International Science and Technology Cooperation Base for Tumor Translational Research of Zhejiang Province, Department of Gastrointestinal Surgery, Department of Gastroenterology, The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Shen","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Clinical Nutrition and Intervention, Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, Department of Oncology, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China"},{"name":"International Science and Technology Cooperation Base for Tumor Translational Research of Zhejiang Province, Department of Gastrointestinal Surgery, Department of Gastroenterology, The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyang","family":"Xue","sequence":"additional","affiliation":[{"name":"Wenzhou Key Laboratory of Cancer-related Pathogens and Immunity, Zhejiang International Cooperation Base for Tumor-Associated Pathogen and Host Interaction, Institute of Molecular Virology and Immunology, Department of Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China"},{"name":"International Science and Technology Cooperation Base for Tumor Translational Research of Zhejiang Province, Department of Gastrointestinal Surgery, Department of Gastroenterology, The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China"},{"name":"Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7942-1505","authenticated-orcid":false,"given":"Zheng","family":"Han","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Clinical Nutrition and Intervention, Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, Department of Oncology, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China"},{"name":"Wenzhou Key Laboratory of Cancer-related Pathogens and Immunity, Zhejiang International Cooperation Base for Tumor-Associated Pathogen and Host Interaction, Institute of Molecular Virology and Immunology, Department of Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"2026093001150723000_14.9.e014475.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200690"},{"key":"2026093001150723000_14.9.e014475.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606774"},{"key":"2026093001150723000_14.9.e014475.3","doi-asserted-by":"crossref","DOI":"10.1001\/jamaoncol.2018.0013","article-title":"Safety and Efficacy of Pembrolizumab Monotherapy in Patients With Previously Treated Advanced Gastric and Gastroesophageal Junction Cancer: Phase 2 Clinical KEYNOTE-059 Trial","volume":"4","author":"Fuchs","year":"2018","journal-title":"JAMA Oncol"},{"key":"2026093001150723000_14.9.e014475.4","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0218-4"},{"key":"2026093001150723000_14.9.e014475.5","article-title":"RNA N6-methyladenosine-binding protein YTHDFs redundantly attenuate cancer immunity by downregulating IFN-\u03b3 signaling in gastric cancer","volume":"12","author":"Jang","year":"2025","journal-title":"Adv Sci Weinh Baden-Wurtt Ger"},{"key":"2026093001150723000_14.9.e014475.6","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00234-5"},{"key":"2026093001150723000_14.9.e014475.7","doi-asserted-by":"publisher","DOI":"10.1038\/nri2381"},{"key":"2026093001150723000_14.9.e014475.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.09.010"},{"key":"2026093001150723000_14.9.e014475.9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-05-429977"},{"key":"2026093001150723000_14.9.e014475.10","doi-asserted-by":"publisher","DOI":"10.1038\/76877"},{"key":"2026093001150723000_14.9.e014475.11","doi-asserted-by":"crossref","DOI":"10.3390\/cells8050463","article-title":"Actin Cytoskeleton Straddling the Immunological Synapse between Cytotoxic Lymphocytes and Cancer Cells","volume":"8","author":"Wurzer","year":"2019","journal-title":"Cells"},{"key":"2026093001150723000_14.9.e014475.12","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.894306","article-title":"Greek Fire, Poison Arrows, and Scorpion Bombs: How Tumor Cells Defend Against the Siege Weapons of Cytotoxic T Lymphocytes","volume":"13","author":"McKenzie","year":"2022","journal-title":"Front Immunol"},{"key":"2026093001150723000_14.9.e014475.13","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-0441"},{"key":"2026093001150723000_14.9.e014475.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.07.005"},{"key":"2026093001150723000_14.9.e014475.15","doi-asserted-by":"publisher","DOI":"10.2174\/157016211798842107"},{"key":"2026093001150723000_14.9.e014475.16","doi-asserted-by":"publisher","DOI":"10.1002\/mc.23158"},{"key":"2026093001150723000_14.9.e014475.17","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: Open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci Rep"},{"key":"2026093001150723000_14.9.e014475.18","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-21-0219"},{"key":"2026093001150723000_14.9.e014475.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.01.011"},{"key":"2026093001150723000_14.9.e014475.20","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.1158\/0008-5472.CAN-22-2593","article-title":"Intratumoral Microbiota Composition Regulates Chemoimmunotherapy Response in Esophageal Squamous Cell Carcinoma","volume":"83","author":"Wu","year":"2023","journal-title":"Cancer Res"},{"key":"2026093001150723000_14.9.e014475.21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.06.009"},{"key":"2026093001150723000_14.9.e014475.22","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.Cd-21-0683"},{"key":"2026093001150723000_14.9.e014475.23","doi-asserted-by":"crossref","DOI":"10.1016\/j.neo.2024.101117","article-title":"Galectin-3 secreted by triple-negative breast cancer cells regulates T cell function","volume":"60","author":"Raiter","year":"2025","journal-title":"Neoplasia"},{"key":"2026093001150723000_14.9.e014475.24","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201407130"},{"key":"2026093001150723000_14.9.e014475.25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3001328","article-title":"Degranulation enhances presynaptic membrane packing, which protects NK cells from perforin-mediated autolysis","volume":"19","author":"Li","year":"2021","journal-title":"PLoS Biol"},{"key":"2026093001150723000_14.9.e014475.26","doi-asserted-by":"crossref","first-page":"112404","DOI":"10.1016\/j.jphotobiol.2022.112404","article-title":"Laurdan in live cell imaging: Effect of acquisition settings, cell culture conditions and data analysis on generalized polarization measurements","volume":"228","author":"Pokorna","year":"2022","journal-title":"J Photochem Photobiol B"},{"key":"2026093001150723000_14.9.e014475.27","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.883178"},{"key":"2026093001150723000_14.9.e014475.28","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2023-225241"},{"key":"2026093001150723000_14.9.e014475.29","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-020-01397-7"},{"key":"2026093001150723000_14.9.e014475.30","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M500439-JLR200"},{"key":"2026093001150723000_14.9.e014475.31","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-20-2569"},{"key":"2026093001150723000_14.9.e014475.32","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2503259122","article-title":"Cancer cells suppress NK cell activity by actin-driven polarization of inhibitory ligands to the immunological synapse","volume":"122","author":"Hoffmann","year":"2025","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026093001150723000_14.9.e014475.33","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1158\/2326-6066.CIR-25-0242","article-title":"Immunotherapy Inhibits Tumor Cholesterol Synthesis via the IFN\u03b3-IRF1-SREBF2 Axis","volume":"14","author":"Xu","year":"2026","journal-title":"Cancer Immunol Res"},{"key":"2026093001150723000_14.9.e014475.34","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1080\/15548627.2025.2519066","article-title":"Tumorous cholesterol biosynthesis curtails anti-tumor immunity by preventing MTOR-TFEB-mediated lysosomal degradation of CD274\/PD-L1","volume":"21","author":"Wang","year":"2025","journal-title":"Autophagy"},{"key":"2026093001150723000_14.9.e014475.35","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0306"},{"key":"2026093001150723000_14.9.e014475.36","doi-asserted-by":"publisher","DOI":"10.1080\/10408363.2019.1660303"},{"key":"2026093001150723000_14.9.e014475.37","doi-asserted-by":"crossref","DOI":"10.1186\/s12929-022-00866-3","article-title":"Tumor microenvironment: barrier or opportunity towards effective cancer therapy","volume":"29","author":"Tiwari","year":"2022","journal-title":"J Biomed Sci"},{"key":"2026093001150723000_14.9.e014475.38","doi-asserted-by":"crossref","DOI":"10.3390\/cells11233817","article-title":"LASP1 in Cellular Signaling and Gene Expression: More than Just a Cytoskeletal Regulator","volume":"11","author":"Butt","year":"2022","journal-title":"Cells"},{"key":"2026093001150723000_14.9.e014475.39","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.90247.2008"},{"key":"2026093001150723000_14.9.e014475.40","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0334-19.2019"},{"key":"2026093001150723000_14.9.e014475.41","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-021-04213-6","article-title":"ECHS1, an interacting protein of LASP1, induces sphingolipid-metabolism imbalance to promote colorectal cancer progression by regulating ceramide glycosylation","volume":"12","author":"Li","year":"2021","journal-title":"Cell Death Dis"},{"key":"2026093001150723000_14.9.e014475.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.02.020"},{"key":"2026093001150723000_14.9.e014475.43","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-21-4370"},{"key":"2026093001150723000_14.9.e014475.44","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s43018-025-01094-y","article-title":"TGF\u03b2 induces an atypical EMT to evade immune mechanosurveillance in lung adenocarcinoma dormant metastasis","volume":"7","author":"Wang","year":"2026","journal-title":"Nat Cancer"},{"key":"2026093001150723000_14.9.e014475.45","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-13385-x","article-title":"Lipid order and charge protect killer T cells from accidental death","volume":"10","author":"Rudd-Schmidt","year":"2019","journal-title":"Nat Commun"},{"key":"2026093001150723000_14.9.e014475.46","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2012.01.007"},{"key":"2026093001150723000_14.9.e014475.47","doi-asserted-by":"crossref","DOI":"10.1038\/s41392-025-02332-6","article-title":"Immunological synapse: structures, molecular mechanisms and therapeutic implications in disease","volume":"10","author":"Chao","year":"2025","journal-title":"Signal Transduct Target Ther"},{"key":"2026093001150723000_14.9.e014475.48","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2050"},{"key":"2026093001150723000_14.9.e014475.49","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.26.021607.090404"},{"key":"2026093001150723000_14.9.e014475.50","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M800078200"},{"key":"2026093001150723000_14.9.e014475.51","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510454103"},{"key":"2026093001150723000_14.9.e014475.52","doi-asserted-by":"crossref","first-page":"537","DOI":"10.3892\/ol.2024.14670","article-title":"T lymphocyte\u2011related immune response and immunotherapy in gastric cancer (Review)","volume":"28","author":"Zhang","year":"2024","journal-title":"Oncol Lett"},{"key":"2026093001150723000_14.9.e014475.53","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2035"},{"key":"2026093001150723000_14.9.e014475.54","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2018.00391","article-title":"New Frontiers for the Cytoskeletal Protein LASP1","volume":"8","author":"Butt","year":"2018","journal-title":"Front Oncol"},{"key":"2026093001150723000_14.9.e014475.55","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.619069","article-title":"Intrinsic Resistance of Chronic Lymphocytic Leukemia Cells to NK Cell-Mediated Lysis Can Be Overcome In Vitro by Pharmacological Inhibition of Cdc42-Induced Actin Cytoskeleton Remodeling","volume":"12","author":"Wurzer","year":"2021","journal-title":"Front Immunol"}],"container-title":["Journal for ImmunoTherapy of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jitc-2025-014475","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:15:15Z","timestamp":1790756115000},"score":1,"resource":{"primary":{"URL":"https:\/\/jitc.bmj.com\/lookup\/doi\/10.1136\/jitc-2025-014475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":55,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9,2]]},"published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1136\/jitc-2025-014475"],"URL":"https:\/\/doi.org\/10.1136\/jitc-2025-014475","relation":{},"ISSN":["2051-1426"],"issn-type":[{"value":"2051-1426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]}}}