{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T12:47:46Z","timestamp":1785934066147,"version":"3.56.0"},"reference-count":49,"publisher":"BMJ","issue":"8","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"unspecified","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82503121"],"award-info":[{"award-number":["82503121"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bengbu Medical University Research Foundation for Advanced Talents","award":["bsqd202401"],"award-info":[{"award-number":["bsqd202401"]}]},{"name":"Bengbu Medical University Research Foundation for Advanced Talents","award":["bsqd202402"],"award-info":[{"award-number":["bsqd202402"]}]},{"name":"Bengbu Medical University Key Program of the Natural Science Foundation","award":["2023byzd025"],"award-info":[{"award-number":["2023byzd025"]}]},{"name":"Bengbu Medical University Key Program of the Natural Science Foundation","award":["2023byzd026"],"award-info":[{"award-number":["2023byzd026"]}]},{"name":"Open Grant from the Anhui Provincial Key Laboratory of Immunology in Chronic Diseases","award":["MBPY202502"],"award-info":[{"award-number":["MBPY202502"]}]},{"name":"Open Grant from the Anhui Provincial Key Laboratory of Immunology in Chronic Diseases","award":["MBPY202508"],"award-info":[{"award-number":["MBPY202508"]}]},{"name":"Anhui Provincial University Scientific Research Key Project","award":["2024AH051210"],"award-info":[{"award-number":["2024AH051210"]}]},{"name":"Anhui Provincial University Scientific Research Key Project","award":["2024AH051212"],"award-info":[{"award-number":["2024AH051212"]}]},{"name":"Anhui Provincial University Scientific Research Key Project","award":["2024AH051213"],"award-info":[{"award-number":["2024AH051213"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Immunother Cancer"],"accepted":{"date-parts":[[2026,7,23]]},"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The low response rate to immunotherapy in patients with lung adenocarcinoma is primarily due to tumor immune evasion. The tumor immunosuppressive microenvironment orchestrates this evasion, yet the underlying mechanisms remain elusive. Here we identify non-specific cytotoxic cell receptor protein 1 (NCCRP1) as a critical and previously uncharacterized regulator of this process.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We first analyzed publicly accessible patient-derived single-cell RNA sequencing and RNA sequencing data to investigate the expression of NCCRP1 in lung adenocarcinoma and its impact on the tumor immune microenvironment. Subsequently, the Nccrp1 gene was knocked out in mouse lung adenocarcinoma cells using CRISPR-Cas9. The effect of NCCRP1 deletion on tumor growth was then evaluated using subcutaneous transplantation models in both NSG and C57BL\/6 mice. Single-cell RNA sequencing, flow cytometry and multiple targeted in vivo interventions were employed to assess the influence of NCCRP1 on the tumor immune microenvironment. To explore the underlying mechanisms by which NCCRP1 regulates the tumor immune microenvironment, we conducted co-immunoprecipitation, RNA pull-down, ubiquitination assay, mass spectrometry, isobaric tags for relative and absolute quantitation proteomics, dual-luciferase reporter gene assay, and ELISA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Loss of NCCRP1 inhibits lung tumor growth and prolongs survival in immunocompetent C57BL\/6\u2009mouse models. NCCRP1 deficiency upregulates CX3CL1 to recruit CX3CR1\n                      <jats:sup>+<\/jats:sup>\n                      antitumoral macrophages. These macrophages subsequently secrete CXCL9 and CXCL10, enhancing the infiltration of CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells and NK cells into the tumor microenvironment. Mechanistically, NCCRP1 and STAU1 competitively bind to NEDD4. NCCRP1 deficiency enhances the STAU1-NEDD4 interaction, promoting ubiquitination and proteasomal degradation of STAU1, thereby increasing\n                      <jats:italic>CX3CL1<\/jats:italic>\n                      messenger RNA stability. Remarkably, ablating NCCRP1 synergized with anti-programmed cell death protein 1 or interferon-\u03b3 therapy, leading to complete tumor eradication.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings highlight NCCRP1 targeting as a promising therapeutic strategy to reprogram the immunosuppressive microenvironment and overcome the \u201ccold tumor\u201d phenotype in lung adenocarcinoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jitc-2026-015072","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T12:05:20Z","timestamp":1785931520000},"page":"e015072","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Loss of NCCRP1 overcomes immune evasion in lung adenocarcinoma"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1160-8076","authenticated-orcid":false,"given":"Lu","family":"Liu","sequence":"first","affiliation":[{"name":"Anhui Provincial Key Laboratory of Immunology in Chronic Diseases, Bengbu Medical University, Bengbu, Anhui, China"},{"name":"Department of Immunology, Basic Medical College, Bengbu Medical University, Bengbu, Anhui, China"},{"name":"Bengbu Medical University Key Laboratory of Cancer Research and Clinical Laboratory Diagnosis, School of Laboratory Medicine, Bengbu Medical University, Bengbu, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2623-7224","authenticated-orcid":false,"given":"Shihao","family":"Qi","sequence":"additional","affiliation":[{"name":"Anhui Provincial Key Laboratory of Immunology in Chronic Diseases, Bengbu Medical University, Bengbu, Anhui, China"},{"name":"Bengbu Medical University Key Laboratory of Cancer Research and Clinical Laboratory Diagnosis, School of Laboratory Medicine, Bengbu Medical University, Bengbu, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3597-4407","authenticated-orcid":false,"given":"Liye","family":"Shao","sequence":"additional","affiliation":[{"name":"Anhui Provincial Key Laboratory of Immunology in Chronic Diseases, Bengbu Medical University, Bengbu, Anhui, China"},{"name":"Bengbu Medical University Key Laboratory of Cancer Research and Clinical Laboratory Diagnosis, School of Laboratory Medicine, Bengbu Medical University, Bengbu, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1850-3719","authenticated-orcid":false,"given":"Junyang","family":"Cai","sequence":"additional","affiliation":[{"name":"Anhui Provincial Key Laboratory of Immunology in Chronic Diseases, Bengbu Medical University, Bengbu, Anhui, China"},{"name":"Bengbu Medical University Key Laboratory of Cancer Research and Clinical Laboratory Diagnosis, School of Laboratory Medicine, Bengbu Medical University, Bengbu, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6985-5034","authenticated-orcid":false,"given":"Qingqing","family":"Zeng","sequence":"additional","affiliation":[{"name":"Anhui Provincial Key Laboratory of Immunology in Chronic Diseases, Bengbu Medical University, Bengbu, Anhui, China"},{"name":"Bengbu Medical University Key Laboratory of Cancer Research and Clinical Laboratory Diagnosis, School of Laboratory Medicine, Bengbu Medical University, Bengbu, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Bengbu Medical University Key Laboratory of Cancer Research and Clinical Laboratory Diagnosis, School of Laboratory Medicine, Bengbu Medical University, Bengbu, Anhui, China"},{"name":"Department of Clinical Laboratory Diagnostics, School of Laboratory Medicine, Bengbu Medical University, Bengbu, Anhui, China"},{"name":"Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Bengbu Medical University, Bengbu, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Ma","sequence":"additional","affiliation":[{"name":"Bengbu Medical University Key Laboratory of Cancer Research and Clinical Laboratory Diagnosis, School of Laboratory Medicine, Bengbu Medical University, Bengbu, Anhui, China"},{"name":"Department of Clinical Laboratory Diagnostics, School of Laboratory Medicine, Bengbu Medical University, Bengbu, Anhui, China"},{"name":"Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Bengbu Medical University, Bengbu, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4050-6957","authenticated-orcid":false,"given":"Weiwei","family":"Lin","sequence":"additional","affiliation":[{"name":"Anhui Provincial Key Laboratory of Immunology in Chronic Diseases, Bengbu Medical University, Bengbu, Anhui, China"},{"name":"Bengbu Medical University Key Laboratory of Cancer Research and Clinical Laboratory Diagnosis, School of Laboratory Medicine, Bengbu Medical University, Bengbu, Anhui, China"},{"name":"Department of Clinical Laboratory Diagnostics, School of Laboratory Medicine, Bengbu Medical University, Bengbu, Anhui, China"},{"name":"Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Bengbu Medical University, Bengbu, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"2026080505050904000_14.8.e015072.1","doi-asserted-by":"publisher","DOI":"10.3322\/CAAC.21834"},{"key":"2026080505050904000_14.8.e015072.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00312-3"},{"key":"2026080505050904000_14.8.e015072.3","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S2213-2600(24)00428-4","article-title":"Estimated worldwide variation and trends in incidence of lung cancer by histological subtype in 2022 and over time: a population-based study","volume":"13","author":"Luo","year":"2025","journal-title":"Lancet Respir Med"},{"key":"2026080505050904000_14.8.e015072.4","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2024-010008","article-title":"Leveraging mitochondrial-programmed cell death dynamics to enhance prognostic accuracy and immunotherapy efficacy in lung adenocarcinoma","volume":"12","author":"Zhang","year":"2024","journal-title":"J Immunother Cancer"},{"key":"2026080505050904000_14.8.e015072.5","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2024-010674","article-title":"Determinants of 5-year survival in patients with advanced NSCLC with PD-L1\u226550% treated with first-line pembrolizumab outside of clinical trials: results from the Pembro-real 5Y global registry","volume":"13","author":"Cortellini","year":"2025","journal-title":"J Immunother Cancer"},{"key":"2026080505050904000_14.8.e015072.6","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05672-3"},{"key":"2026080505050904000_14.8.e015072.7","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2023-007402","article-title":"Loss of ADAR1 in macrophages in combination with interferon gamma suppresses tumor growth by remodeling the tumor microenvironment","volume":"11","author":"Lin","year":"2023","journal-title":"J Immunother Cancer"},{"key":"2026080505050904000_14.8.e015072.8","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-20-2673"},{"key":"2026080505050904000_14.8.e015072.9","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202207499","article-title":"Checkpoint TIPE2 Limits the Helper Functions of NK Cells in Supporting Antitumor CD8+ T Cells","volume":"10","author":"Bi","year":"2023","journal-title":"Adv Sci (Weinh)"},{"key":"2026080505050904000_14.8.e015072.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.04.014"},{"key":"2026080505050904000_14.8.e015072.11","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01687-8"},{"key":"2026080505050904000_14.8.e015072.12","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03651-8"},{"key":"2026080505050904000_14.8.e015072.13","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-08257-4"},{"key":"2026080505050904000_14.8.e015072.14","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-1868"},{"key":"2026080505050904000_14.8.e015072.15","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abo5570","article-title":"Immunogenomic cancer evolution: A framework to understand cancer immunosuppression","volume":"10","author":"Kumagai","year":"2025","journal-title":"Sci Immunol"},{"key":"2026080505050904000_14.8.e015072.16","doi-asserted-by":"crossref","first-page":"109594","DOI":"10.1016\/j.fsi.2024.109594","article-title":"Novel C-type lectin mediated non-specific cytotoxic cells killing activity through NCCRP-1 in nile tilapia (Oreochromis niloticus)","volume":"149","author":"Huang","year":"2024","journal-title":"Fish Shellfish Immunol"},{"key":"2026080505050904000_14.8.e015072.17","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-024-00984-x"},{"key":"2026080505050904000_14.8.e015072.18","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1158\/0008-5472.CAN-24-2289","article-title":"Characterization of an Enhancer RNA Signature Reveals Treatment Strategies for Improving Immunotherapy Efficacy in Cancer","volume":"85","author":"Zhang","year":"2025","journal-title":"Cancer Res"},{"key":"2026080505050904000_14.8.e015072.19","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41586-024-08439-0","article-title":"Immune evasion through mitochondrial transfer in the tumour microenvironment","volume":"638","author":"Ikeda","year":"2025","journal-title":"Nature"},{"key":"2026080505050904000_14.8.e015072.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.09.010"},{"key":"2026080505050904000_14.8.e015072.21","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2922-4"},{"key":"2026080505050904000_14.8.e015072.22","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1182\/blood.2024025643","article-title":"Aberrant single-cell phenotype and clinical implications of genotypically defined polyclonal plasma cells in myeloma","volume":"145","author":"Da Vi\u00e0","year":"2025","journal-title":"Blood"},{"key":"2026080505050904000_14.8.e015072.23","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky900"},{"key":"2026080505050904000_14.8.e015072.24","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01398-6"},{"key":"2026080505050904000_14.8.e015072.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.042"},{"key":"2026080505050904000_14.8.e015072.26","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.adl2171","article-title":"The tumor-intrinsic role of the m6A reader YTHDF2 in regulating immune evasion","volume":"9","author":"Xiao","year":"2024","journal-title":"Sci Immunol"},{"key":"2026080505050904000_14.8.e015072.27","doi-asserted-by":"crossref","unstructured":"Cai J , Zhang P , Cai Y , et al . Lactylation\u2010Driven NUPR1 Promotes Immunosuppression of Tumor\u2010Infiltrating Macrophages in Hepatocellular Carcinoma. Advanced Science 2025;12. doi:10.1002\/advs.202413095","DOI":"10.1002\/advs.202413095"},{"key":"2026080505050904000_14.8.e015072.28","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/s43018-024-00743-y","article-title":"Sarcoma microenvironment cell states and ecosystems are associated with prognosis and predict response to immunotherapy","volume":"5","author":"Subramanian","year":"2024","journal-title":"Nat Cancer"},{"key":"2026080505050904000_14.8.e015072.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.06.001"},{"key":"2026080505050904000_14.8.e015072.30","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-025-00832-9"},{"key":"2026080505050904000_14.8.e015072.31","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/s41575-021-00444-2","article-title":"Regulation and functional roles of chemokines in liver diseases","volume":"18","author":"Cao","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2026080505050904000_14.8.e015072.32","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.cmet.2025.01.006","article-title":"Sweetener aspartame aggravates atherosclerosis through insulin-triggered inflammation","volume":"37","author":"Wu","year":"2025","journal-title":"Cell Metab"},{"key":"2026080505050904000_14.8.e015072.33","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-022-00507-5"},{"key":"2026080505050904000_14.8.e015072.34","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2409724122","article-title":"ADARp110 promotes hepatocellular carcinoma progression via stabilization of CD24 mRNA","volume":"122","author":"Sun","year":"2025","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026080505050904000_14.8.e015072.35","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.05.014"},{"key":"2026080505050904000_14.8.e015072.36","doi-asserted-by":"crossref","DOI":"10.1172\/JCI176390","article-title":"Pharmacological suppression of the OTUD4\/CD73 proteolytic axis revives antitumor immunity against immune-suppressive breast cancers","volume":"134","author":"Zhu","year":"2024","journal-title":"J Clin Invest"},{"key":"2026080505050904000_14.8.e015072.37","doi-asserted-by":"crossref","unstructured":"Wang S , Iyer R , Han X , et al . CRISPR screening identifies the deubiquitylase ATXN3 as a PD-L1\u2013positive regulator for tumor immune evasion. J Clin Invest 2023;133. doi:10.1172\/JCI167728","DOI":"10.1172\/JCI167728"},{"key":"2026080505050904000_14.8.e015072.38","doi-asserted-by":"publisher","DOI":"10.1016\/J.IMMUNI.2025.06.006"},{"key":"2026080505050904000_14.8.e015072.39","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.tcb.2023.03.008","article-title":"Glucose metabolism of TAMs in tumor chemoresistance and metastasis","volume":"33","author":"Liu","year":"2023","journal-title":"Trends Cell Biol"},{"key":"2026080505050904000_14.8.e015072.40","doi-asserted-by":"crossref","DOI":"10.1186\/s13046-022-02564-2","article-title":"Cyclin G2 in macrophages triggers CTL-mediated antitumor immunity and antiangiogenesis via interferon-gamma","volume":"41","author":"Liu","year":"2022","journal-title":"J Exp Clin Cancer Res"},{"key":"2026080505050904000_14.8.e015072.41","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.106443","article-title":"CX3CR1 deficiency-induced TIL tumor restriction as a novel addition for CAR-T design in solid malignancies","volume":"26","author":"Trinh","year":"2023","journal-title":"iScience"},{"key":"2026080505050904000_14.8.e015072.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.05.013"},{"key":"2026080505050904000_14.8.e015072.43","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/s41556-026-01925-9","article-title":"Reinvigorating COTL1high NK cells via GITR signalling overcomes immune checkpoint blockade resistance in tsMHC-I-impaired tumours","volume":"28","author":"You","year":"2026","journal-title":"Nat Cell Biol"},{"key":"2026080505050904000_14.8.e015072.44","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.07.016"},{"key":"2026080505050904000_14.8.e015072.45","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-22755-3","article-title":"IFN-\u03b3-dependent NK cell activation is essential to metastasis suppression by engineered Salmonella","volume":"12","author":"Lin","year":"2021","journal-title":"Nat Commun"},{"key":"2026080505050904000_14.8.e015072.46","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1038\/s41586-025-09071-2","article-title":"Concurrent loss of the Y chromosome in cancer and T cells impacts outcome","volume":"642","author":"Chen","year":"2025","journal-title":"Nature"},{"key":"2026080505050904000_14.8.e015072.47","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abi9533","article-title":"Loss of TSC1\/TSC2 sensitizes immune checkpoint blockade in non-small cell lung cancer","volume":"8","author":"Huang","year":"2022","journal-title":"Sci Adv"},{"key":"2026080505050904000_14.8.e015072.48","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab905"},{"key":"2026080505050904000_14.8.e015072.49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000411","article-title":"Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol"}],"container-title":["Journal for ImmunoTherapy of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jitc-2026-015072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T12:05:25Z","timestamp":1785931525000},"score":1,"resource":{"primary":{"URL":"https:\/\/jitc.bmj.com\/lookup\/doi\/10.1136\/jitc-2026-015072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":49,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8,5]]},"published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1136\/jitc-2026-015072"],"URL":"https:\/\/doi.org\/10.1136\/jitc-2026-015072","relation":{},"ISSN":["2051-1426"],"issn-type":[{"value":"2051-1426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]}}}