{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:38:19Z","timestamp":1790037499396,"version":"4.0.1"},"reference-count":52,"publisher":"BMJ","issue":"6","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"unspecified","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"R\u00e9gion Bourgogne-Franche-Comte","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"ANR","award":["ANR-23-CE17-0016"],"award-info":[{"award-number":["ANR-23-CE17-0016"]}]},{"name":"I-site-BFC program","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"DOI":"10.13039\/501100004097","name":"Fondation ARC","doi-asserted-by":"crossref","award":["ARCPJA2021060003768"],"award-info":[{"award-number":["ARCPJA2021060003768"]}],"id":[{"id":"10.13039\/501100004097","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004097","name":"Fondation ARC","doi-asserted-by":"crossref","award":["ARCPJA2024060008395"],"award-info":[{"award-number":["ARCPJA2024060008395"]}],"id":[{"id":"10.13039\/501100004097","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002717","name":"Minist\u00e8re de l\u2019Enseignement Sup\u00e9rieur et de la Recherche Scientifique","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100002717","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004099","name":"Ligue Nationale contre le Cancer","doi-asserted-by":"crossref","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"crossref","award":["ANR-11-LABX-0021"],"award-info":[{"award-number":["ANR-11-LABX-0021"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["FDT202304016666"],"award-info":[{"award-number":["FDT202304016666"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ligue contre le Cancer CCIR-GE","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Immunother Cancer"],"accepted":{"date-parts":[[2026,5,30]]},"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The combination of antiangiogenic therapy with immune checkpoint blockade has demonstrated significant clinical benefits in various cancers, however, the precise mechanisms of action on the immune system are not fully understood. In particular, the early intratumoral immune responses induced by angiogenesis inhibition remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using preclinical models of colorectal cancer, we examined the immune changes elicited by combined vascular endothelial growth factor receptor-2 (VEGFR-2) and programmed cell death protein-1 (PD-1) blockade.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our findings reveal that CD8 T cells respond directly and early to VEGFR-2 inhibition, preceding the acquisition of overt cytotoxic function. Shortly after treatment, intratumoral CD8 T cells expanded and produced interleukin-10 (IL-10). Unexpectedly, this CD8 T cell-derived IL-10 promoted the recruitment of natural killer (NK) cells into tumors. Recruited NK cells subsequently gained effector activity and produced granulocyte-macrophage colony-stimulating factor, which supported macrophage maturation and the induction of CXCL11. This sequence of events enhanced secondary CD8 T-cell infiltration and sustained antitumor immune activity. Disruption of IL-10 signaling or NK-cell function eliminated the therapeutic benefit of combined VEGFR-2 and PD-1 blockade, whereas regulatory T-cell depletion further improved tumor control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Together, these findings identify an unanticipated role for CD8 T cell-derived IL-10 in coordinating early innate and adaptive immune responses following angiogenesis inhibition and define an immune program initiated by VEGFR-2 blockade that is required for therapeutic efficacy in two preclinical colorectal cancer models.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jitc-2026-015243","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T14:56:23Z","timestamp":1782140183000},"page":"e015243","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["IL-10 secretion by CD8 T cells orchestrates early NK cell recruitment and antitumor immunity after anti-VEGFR-2\/PD-1 therapy"],"prefix":"10.1136","volume":"14","author":[{"given":"Mannon","family":"Geindreau","sequence":"first","affiliation":[{"name":"Universit\u00e9 Bourgogne Europe, UMR INSERM 1231, TIRECs team, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassandre","family":"Pignol","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Bourgogne Europe, UMR INSERM 1231, TIRECs team, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lo\u00efs","family":"Co\u00ebnon","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Bourgogne Europe, UMR INSERM 1231, TIRECs team, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Varin","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Franche-Comt\u00e9, UBFC, EFS, Inserm UMR RIGHT, Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Racoeur","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Bourgogne Europe, UMR INSERM 1231, TIRECs team, Dijon, France"},{"name":"Immunology and Immunotherapy of Cancer Laboratory, EPHE, PSL Research University, Paris, \u00cele-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lylou","family":"Milian","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Bourgogne Europe, UMR INSERM 1231, TIRECs team, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nolwenn","family":"Roger","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Bourgogne Europe, UMR INSERM 1231, TIRECs team, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Chalmin","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Bourgogne Europe, Centre Georges-Fran\u00e7ois Leclerc, Unicancer, Cancer Biology 14 Transfer Platform, UMR INSERM 1231, TIRECs team, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibault","family":"Vernet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Bourgogne Europe, Centre Georges-Fran\u00e7ois Leclerc, Unicancer, Cancer Biology 14 Transfer Platform, UMR INSERM 1231, TIRECs team, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Line","family":"Alibert","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Bourgogne Europe, UMR INSERM 1231, TIRECs team, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Simon","family":"Bellaye","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Bourgogne Europe, UMR INSERM 1231, TIRECs team, Dijon, France"},{"name":"Centre Georges-Fran\u00e7ois Leclerc, Service de m\u00e9decine nucl\u00e9aire, Plateforme d'imagerie et de 16 radioth\u00e9rapie pr\u00e9cliniques, Dijon, Bourgogne-Franche-Comt\u00e9, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1046-5982","authenticated-orcid":false,"given":"Marion","family":"Thibaudin","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Bourgogne Europe, Centre Georges-Fran\u00e7ois Leclerc, Unicancer, Cancer Biology 14 Transfer Platform, UMR INSERM 1231, TIRECs team, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Louis","sequence":"additional","affiliation":[{"name":"Inflammation Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Wicks","sequence":"additional","affiliation":[{"name":"Inflammation Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0895-4813","authenticated-orcid":false,"given":"Caroline","family":"Truntzer","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Franche-Comt\u00e9, UBFC, EFS, Inserm UMR RIGHT, Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Boidot","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Biologie Mol\u00e9culaire, Georges-Fran\u00e7ois Leclerc Centre, Dijon, Bourgogne-Franche-Comt\u00e9, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7657-5535","authenticated-orcid":false,"given":"Catherine","family":"Paul","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Bourgogne Europe, UMR INSERM 1231, TIRECs team, Dijon, France"},{"name":"Immunology and Immunotherapy of Cancer Laboratory, EPHE, PSL Research University, Paris, \u00cele-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baptiste","family":"Lamarth\u00e9e","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Franche-Comt\u00e9, UBFC, EFS, Inserm UMR RIGHT, Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4377-1441","authenticated-orcid":false,"given":"Frederique","family":"Vegran","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Bourgogne Europe, Centre Georges-Fran\u00e7ois Leclerc, Unicancer, Cancer Biology 14 Transfer Platform, UMR INSERM 1231, TIRECs team, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5465-8305","authenticated-orcid":false,"given":"Francois","family":"Ghiringhelli","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Bourgogne Europe, Centre Georges-Fran\u00e7ois Leclerc, Unicancer, Cancer Biology 14 Transfer Platform, UMR INSERM 1231, TIRECs team, Dijon, France"},{"name":"Genetic and Immunology Medical Institute, Dijon, Bourgogne-Franche-Comt\u00e9, France"},{"name":"Department of Medical Oncology, Centre Georges-Fran\u00e7ois Leclerc, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0004-2887","authenticated-orcid":false,"given":"M\u00e9lanie","family":"Bruchard","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Bourgogne Europe, Centre Georges-Fran\u00e7ois Leclerc, Unicancer, Cancer Biology 14 Transfer Platform, UMR INSERM 1231, TIRECs team, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"2026062207552538000_14.6.e015243.1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.26094"},{"key":"2026062207552538000_14.6.e015243.2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-2176"},{"key":"2026062207552538000_14.6.e015243.3","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-019-0974-6","article-title":"Synergistic effect of immune checkpoint blockade and anti-angiogenesis in cancer treatment","volume":"18","author":"Yi","year":"2019","journal-title":"Mol Cancer"},{"key":"2026062207552538000_14.6.e015243.4","doi-asserted-by":"crossref","unstructured":"Schmittnaegel M , Rigamonti N , Kadioglu E , et al . Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade. Sci Transl Med 2017;9. doi:10.1126\/scitranslmed.aak9670","DOI":"10.1126\/scitranslmed.aak9670"},{"key":"2026062207552538000_14.6.e015243.5","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(19)30027-0"},{"key":"2026062207552538000_14.6.e015243.6","doi-asserted-by":"crossref","DOI":"10.1016\/j.annonc.2024.08.583","article-title":"514MO The efficacy and safety of ivonescimab with or without ligufalimab in combination with FOLFOXIRI as first-line (1L) treatment for metastatic colorectal cancer (mCRC)","volume":"35","author":"Deng","year":"2024","journal-title":"Ann Oncol"},{"key":"2026062207552538000_14.6.e015243.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2019.02.001"},{"key":"2026062207552538000_14.6.e015243.8","doi-asserted-by":"publisher","DOI":"10.1038\/nm1492"},{"key":"2026062207552538000_14.6.e015243.9","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-00940-2"},{"key":"2026062207552538000_14.6.e015243.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2018.10.007"},{"key":"2026062207552538000_14.6.e015243.11","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1996"},{"key":"2026062207552538000_14.6.e015243.12","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.468"},{"key":"2026062207552538000_14.6.e015243.13","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003292"},{"key":"2026062207552538000_14.6.e015243.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.06.008"},{"key":"2026062207552538000_14.6.e015243.15","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-43283-2","article-title":"SEPTIN2 suppresses an IFN-\u03b3-independent, proinflammatory macrophage activation pathway","volume":"14","author":"Fu","year":"2023","journal-title":"Nat Commun"},{"key":"2026062207552538000_14.6.e015243.16","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevEukarGeneExpr.v20.i2.10"},{"key":"2026062207552538000_14.6.e015243.17","doi-asserted-by":"crossref","unstructured":"Louis C , Souza-Fonseca-Guimaraes F , Yang Y , et al . NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS. J Exp Med 2020;217. doi:10.1084\/jem.20191421","DOI":"10.1084\/jem.20191421"},{"key":"2026062207552538000_14.6.e015243.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.04.010"},{"key":"2026062207552538000_14.6.e015243.19","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1038\/nature04651","article-title":"Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell\u2013dendritic cell interaction","volume":"440","author":"Castellino","year":"2006","journal-title":"Nature New Biol"},{"key":"2026062207552538000_14.6.e015243.20","doi-asserted-by":"crossref","DOI":"10.1186\/s40425-019-0757-z","article-title":"IL-17 inhibits CXCL9\/10-mediated recruitment of CD8+ cytotoxic T cells and regulatory T cells to colorectal tumors","volume":"7","author":"Chen","year":"2019","journal-title":"J Immunother Cancer"},{"key":"2026062207552538000_14.6.e015243.21","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.10.6713"},{"key":"2026062207552538000_14.6.e015243.22","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.4.2036-a"},{"key":"2026062207552538000_14.6.e015243.23","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2108330"},{"key":"2026062207552538000_14.6.e015243.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.11.030"},{"key":"2026062207552538000_14.6.e015243.25","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1816047"},{"key":"2026062207552538000_14.6.e015243.26","first-page":"187","article-title":"Immunological Effects of Bevacizumab-Based Treatment in Metastatic Colorectal Cancer","volume":"79","author":"Manzoni","year":"2011","journal-title":"Oncology (Williston Park, NY)"},{"key":"2026062207552538000_14.6.e015243.27","doi-asserted-by":"crossref","DOI":"10.1186\/s40425-018-0403-1","article-title":"Targeting VEGFR2 with Ramucirumab strongly impacts effector\/ activated regulatory T cells and CD8+ T cells in the tumor microenvironment","volume":"6","author":"Tada","year":"2018","journal-title":"J Immunother Cancer"},{"key":"2026062207552538000_14.6.e015243.28","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20140559"},{"key":"2026062207552538000_14.6.e015243.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.05.012"},{"key":"2026062207552538000_14.6.e015243.30","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-10-3994"},{"key":"2026062207552538000_14.6.e015243.31","doi-asserted-by":"crossref","first-page":"619195","DOI":"10.3389\/fimmu.2021.619195","article-title":"IL-10 Enhances Human Natural Killer Cell Effector Functions via Metabolic Reprogramming Regulated by mTORC1 Signaling","volume":"12","author":"Wang","year":"2021","journal-title":"Front Immunol"},{"key":"2026062207552538000_14.6.e015243.32","doi-asserted-by":"publisher","DOI":"10.1007\/s10059-011-1057-8"},{"key":"2026062207552538000_14.6.e015243.33","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364135"},{"key":"2026062207552538000_14.6.e015243.34","first-page":"5044","article-title":"Interleukin\u201110 promotes proliferation and migration, and inhibits tendon differentiation via the JAK\/Stat3 pathway in tendon\u2011derived stem cells in vitro","volume":"18","author":"Deng","year":"2018","journal-title":"Mol Med Rep"},{"key":"2026062207552538000_14.6.e015243.35","doi-asserted-by":"publisher","DOI":"10.1007\/s12307-018-0215-3"},{"key":"2026062207552538000_14.6.e015243.36","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701280"},{"key":"2026062207552538000_14.6.e015243.37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.10.018"},{"key":"2026062207552538000_14.6.e015243.38","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.132"},{"key":"2026062207552538000_14.6.e015243.39","doi-asserted-by":"crossref","unstructured":"Harvey RF , P\u00f6yry TAA , Stoneley M , et al . Signaling from mTOR to eIF2\u03b1 mediates cell migration in response to the chemotherapeutic doxorubicin. Sci Signal 2019;12. doi:10.1126\/scisignal.aaw6763","DOI":"10.1126\/scisignal.aaw6763"},{"key":"2026062207552538000_14.6.e015243.40","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aao5838","article-title":"Mammalian EAK-7 activates alternative mTOR signaling to regulate cell proliferation and migration","volume":"4","author":"Nguyen","year":"2018","journal-title":"Sci Adv"},{"key":"2026062207552538000_14.6.e015243.41","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115306"},{"key":"2026062207552538000_14.6.e015243.42","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20102101"},{"key":"2026062207552538000_14.6.e015243.43","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.06.003"},{"key":"2026062207552538000_14.6.e015243.44","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-2325"},{"key":"2026062207552538000_14.6.e015243.45","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0346-9"},{"key":"2026062207552538000_14.6.e015243.46","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELL.2021.04.048"},{"key":"2026062207552538000_14.6.e015243.47","unstructured":"Varin A . RightOmicsTools: an r package providing complementary tools for the manipulation and visualization of single cell rna-seq data. Zenodo,"},{"key":"2026062207552538000_14.6.e015243.48","unstructured":"Marsh S , Salmon M , Hoffman P , et al . Samuel-marsh\/sccustomize: version 3.2.2. Zenodo"},{"key":"2026062207552538000_14.6.e015243.49","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-024-01045-4"},{"key":"2026062207552538000_14.6.e015243.50","doi-asserted-by":"crossref","DOI":"10.1093\/bioadv\/vbad130","article-title":"CCPlotR: an R package for the visualization of cell-cell interactions","volume":"3","author":"Ennis","year":"2023","journal-title":"Bioinform Adv"},{"key":"2026062207552538000_14.6.e015243.51","unstructured":"Korotkevich G , Sukhov V , Budin N , et al . Fast gene set enrichment analysis. bioRxiv 2021;060012."},{"key":"2026062207552538000_14.6.e015243.52","unstructured":"I, D . Msigdbr: msigdb gene sets for multiple organisms in a tidy data format. 2025."}],"container-title":["Journal for ImmunoTherapy of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jitc-2026-015243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T14:56:38Z","timestamp":1782140198000},"score":1,"resource":{"primary":{"URL":"https:\/\/jitc.bmj.com\/lookup\/doi\/10.1136\/jitc-2026-015243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":52,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6,22]]},"published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1136\/jitc-2026-015243"],"URL":"https:\/\/doi.org\/10.1136\/jitc-2026-015243","relation":{},"ISSN":["2051-1426"],"issn-type":[{"value":"2051-1426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]}}}