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While alternative splicing (AS) shapes tumor immunity, the lack of large-scale, consensus-based datasets constrains the characterization of ICB-specific splicing landscapes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We developed TCASIA (the Cancer Alternative Splicing Immunotherapy Atlas), harmonizing &gt;4000 samples across 29 cohorts. A rigorous \u201c2-out-of-4\u201d multi-algorithm consensus framework (rMATS, MAJIQ, SUPPA2, and SplAdder) with a fuzzy matching strategy was used to establish a high-confidence AS landscape.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      TCASIA provides a robust toolkit linking splicing perturbations with clinical phenotypes (response, survival, and immune infiltration). Using this platform, we recapitulated the established\n                      <jats:italic>FAS<\/jats:italic>\n                      exon 6 skipping mechanism and identified\n                      <jats:italic>IL7R<\/jats:italic>\n                      exon 6 skipping as a functionally supported candidate associated with reduced CD8\n                      <jats:sup>+<\/jats:sup>\n                      T-cell infiltration and poor survival in melanoma.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TCASIA provides an analytical atlas for investigating splicing-mediated immune evasion and prioritizing isoform-specific candidates for further functional and clinical validation in the context of ICB treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jitc-2026-015364","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:00:26Z","timestamp":1791385226000},"page":"e015364","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["TCASIA: an integrative atlas linking alternative splicing landscapes for cancer immunotherapy"],"prefix":"10.1136","volume":"14","author":[{"given":"Yihao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Oncology, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China"},{"name":"Guizhou Provincial Key Laboratory for Tumor Prevention and Treatment, Zunyi Medical University, Zunyi, Guizhou, China"},{"name":"Department of Neurosurgery, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"},{"name":"Department of 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