{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T18:47:14Z","timestamp":1782240434480,"version":"3.54.5"},"reference-count":10,"publisher":"BMJ","issue":"6","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"unspecified","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Immunother Cancer"],"accepted":{"date-parts":[[2026,6,8]]},"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>\n                    The results of a recent comprehensive investigation\u2014confirmed in multiple cohorts\u2014show that patients with hepatocellular carcinoma, who favorably responded to anti-programmed cell death protein 1 (PD-1) therapy, were enriched in IgG1-producing plasma cells. The clonally expanded cells in responders also showed upregulation of\n                    <jats:italic>IGHG1<\/jats:italic>\n                    , the gene encoding the IgG1 antibodies. IgG1 expresses four GM (\u03b3 marker) allotypes: GM 1\/a, GM 2\/x, GM 3\/f and GM 17\/z. There are well-established associations between these allotypes and IgG subclass concentrations. Additionally, these determinants influence autoantibody responses to tumor-associated antigens and contribute to the antibody-dependent cellular cytotoxicity of tumors. Based on these and other observations, I hypothesize that GM allotypes expressed on IgG1 could potentially serve as genetic markers of response to anti-PD-1 and other immune checkpoint blockade therapies characterized by the skewed expansion of IgG1 plasma cells.\n                  <\/jats:p>","DOI":"10.1136\/jitc-2026-015682","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T17:55:22Z","timestamp":1782237322000},"page":"e015682","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Immunoglobulin GM (\u03b3 marker) allotypes expressed on IgG1 as potential genetic markers of response to immune checkpoint blockade therapy"],"prefix":"10.1136","volume":"14","author":[{"given":"Janardan P","family":"Pandey","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA"},{"name":"Department of Pharmacology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"2026062310551642000_14.6.e015682.1","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1093\/jimmun\/vkaf190","article-title":"Immunoglobulin GM (\u03b3 marker) allotypes and their role in immune response and disease susceptibility","volume":"214","author":"Pandey","year":"2025","journal-title":"J Immunol"},{"key":"2026062310551642000_14.6.e015682.2","doi-asserted-by":"crossref","first-page":"649","DOI":"10.3390\/biomedinformatics3030044","article-title":"Human Gm, Km, and Am Allotypes: WHO\/IMGT Nomenclature and IMGT Unique Numbering for Immunoinformatics and Therapeutical Antibodies","volume":"3","author":"Lefranc","year":"2023","journal-title":"BioMedInformatics"},{"key":"2026062310551642000_14.6.e015682.3","doi-asserted-by":"publisher","DOI":"10.1038\/s41435-021-00156-2"},{"key":"2026062310551642000_14.6.e015682.4","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01161","article-title":"Unveiling the Diversity of Immunoglobulin Heavy Constant Gamma (IGHG) Gene Segments in Brazilian Populations Reveals 28 Novel Alleles and Evidence of Gene Conversion and Natural Selection","volume":"10","author":"Calonga-Sol\u00eds","year":"2019","journal-title":"Front Immunol"},{"key":"2026062310551642000_14.6.e015682.5","first-page":"191","article-title":"Advances in human immunoglobulin allotypes","volume":"12","author":"Grubb","year":"1995","journal-title":"Exp Clin Immunogenet"},{"key":"2026062310551642000_14.6.e015682.6","doi-asserted-by":"publisher","DOI":"10.1007\/BF00918793"},{"key":"2026062310551642000_14.6.e015682.7","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/s41591-025-04177-6","article-title":"Humoral IgG1 responses to tumor antigens underpin clinical outcomes in immune checkpoint blockade","volume":"32","author":"Gonzalez-Kozlova","year":"2026","journal-title":"Nat Med"},{"key":"2026062310551642000_14.6.e015682.8","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-5607"},{"key":"2026062310551642000_14.6.e015682.9","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nou298"},{"key":"2026062310551642000_14.6.e015682.10","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/cei.12247","article-title":"Genetic variants of immunoglobulin \u03b3 and \u03ba chains influence humoral immunity to the cancer-testis antigen XAGE-1b (GAGED2a) in patients with non-small cell lung cancer","volume":"176","author":"Pandey","year":"2014","journal-title":"Clin Exp Immunol"}],"container-title":["Journal for ImmunoTherapy of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jitc-2026-015682","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T17:55:23Z","timestamp":1782237323000},"score":1,"resource":{"primary":{"URL":"https:\/\/jitc.bmj.com\/lookup\/doi\/10.1136\/jitc-2026-015682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":10,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6,23]]},"published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1136\/jitc-2026-015682"],"URL":"https:\/\/doi.org\/10.1136\/jitc-2026-015682","relation":{},"ISSN":["2051-1426"],"issn-type":[{"value":"2051-1426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]}}}