{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T22:40:05Z","timestamp":1758753605758,"version":"3.44.0"},"reference-count":4,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Ethics"],"published-print":{"date-parts":[[1994,12]]},"abstract":"<jats:p>The ability to improve diagnosis and refine prognosis in children with acute leukaemia is improving steadily. A growing number of tests can and are being performed on leukaemic cells. These include surface-marker analysis, DNA content, cytogenetics and studies of gene rearrangements. Increasingly large bone-marrow samples, now usually obtained under general anaesthesia, are required to make secure diagnoses. Ethical issues arise from three major areas. 1) Current research on leukaemia cells requested by the Medical Research Council is considered by local research ethics committees, but parents are not regularly given detailed information about or asked specifically to consent to such research; 2) substantial quantities of excess cells are stored indefinitely. This archive of stored material is a valuable resource for research but there has been little consideration of the ethical issues which arise from this practice, and 3) there is a potential for pressure to obtain increasingly large samples. 'Creeping growth' in sample size is likely to continue unless ethics committees consider future research proposals in more detail. These issues deserve attention in order that worthwhile research and its publication are not impeded for want of ethical consideration. The implications extend beyond the field of childhood leukaemia.<\/jats:p>","DOI":"10.1136\/jme.20.4.225","type":"journal-article","created":{"date-parts":[[2008,11,5]],"date-time":"2008-11-05T19:48:04Z","timestamp":1225914484000},"page":"225-228","source":"Crossref","is-referenced-by-count":1,"title":["Research on leukaemia cells surplus to diagnostic needs in children."],"prefix":"10.1136","volume":"20","author":[{"given":"M M","family":"Reid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1994,12,1]]},"reference":[{"key":"ref_1","article-title":"Guidelines for the ethical conduct of medical research involving children","author":"Ethics Advisory Committee of the British Paediatric Association","year":"1992","unstructured":"Ethics Advisory Committee of the British Paediatric Association. Guidelines for the ethical conduct of medical research involving children. London: British Paediatric Association, 1992."},{"article-title":"A newsletter called Ethics and Intellectual Disability will be published twice a year, starting in winter","year":"1995","key":"ref_2","unstructured":"A newsletter called Ethics and Intellectual Disability will be published twice a year, starting in winter 1995."},{"key":"ref_3","article-title":"Members of the network can pass scientifically relevant","volume-title":"information to the editor. The network participates in the scientific activities of the International Association of Bioethics. Co-ordinator of the network and editor of its newsletter is Prof","author":"S, J.","unstructured":"Members of the network can pass scientifically relevant information to the editor. The network participates in the scientific activities of the International Association of Bioethics. Co-ordinator of the network and editor of its newsletter is Prof Dr J S Reinders, Institute for Ethics, Free University, 1081 HV Amsterdam, the Netherlands."},{"key":"ref_4","first-page":"444","article-title":"Fellowship in clinical bioethics The Department of Bioethics at the Cleveland Clinic Foundation invites applications for a one year Bioethics Fellowship residency, beginning","volume-title":"The programme has an interdisciplinary focus and includes academic, clinical and research bioethics components. Each fellowship is tailored to meet individual strengths, needs and interests. Concentrations in medical subspecialties (for example, geriatrics, infectious disease) are available. Stipend and health care benefits are provided. Completed applications must be received by","year":"1995","unstructured":"Fellowship in clinical bioethics The Department of Bioethics at the Cleveland Clinic Foundation invites applications for a one year Bioethics Fellowship residency, beginning 1 July 1995. The programme has an interdisciplinary focus and includes academic, clinical and research bioethics components. Each fellowship is tailored to meet individual strengths, needs and interests. Concentrations in medical subspecialties (for example, geriatrics, infectious disease) are available. Stipend and health care benefits are provided. Completed applications must be received by 15 January 1995. For information contact: Martin L Smith, STD, Department of Bioethics, P-31 Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA. Telephone: (216) 444-8720."}],"container-title":["Journal of Medical Ethics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jme.20.4.225","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T22:20:50Z","timestamp":1758752450000},"score":1,"resource":{"primary":{"URL":"https:\/\/jme.bmj.com\/lookup\/doi\/10.1136\/jme.20.4.225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,12]]},"references-count":4,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1994,12,1]]},"published-print":{"date-parts":[[1994,12]]}},"alternative-id":["10.1136\/jme.20.4.225"],"URL":"https:\/\/doi.org\/10.1136\/jme.20.4.225","relation":{},"ISSN":["0306-6800","1473-4257"],"issn-type":[{"type":"print","value":"0306-6800"},{"type":"electronic","value":"1473-4257"}],"subject":[],"published":{"date-parts":[[1994,12]]}}}