{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:17:13Z","timestamp":1791037033400,"version":"4.1.0"},"reference-count":32,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"accepted":{"date-parts":[[2013,3,10]]},"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Mutations in <jats:italic>BRCA1\/2<\/jats:italic> genes confer ovarian, alongside breast, cancer risk. We examined the risk of developing ovarian cancer in <jats:italic>BRCA1\/2<\/jats:italic>-positive families and if this risk is extended to <jats:italic>BRCA<\/jats:italic> negative families.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients and Methods<\/jats:title>\n                  <jats:p>A prospective study involving women seen at a single family history clinic in Manchester, UK. Patients were excluded if they had ovarian cancer or oophorectomy prior to clinic. Follow-up was censored at the latest date of: 31\/12\/2010; ovarian cancer diagnosis; oophorectomy; or death. We used person-years at risk to assess ovarian cancer rates in the study population, subdivided by genetic status (<jats:italic>BRCA1<\/jats:italic>, <jats:italic>BRCA2<\/jats:italic>, <jats:italic>BRCA<\/jats:italic> negative, <jats:italic>BRCA<\/jats:italic> untested) compared with the general population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We studied 8005 women from 895 families. Women from <jats:italic>BRCA2<\/jats:italic> mutation families showed a 17-fold increased risk of invasive ovarian cancer (relative risk (RR) 16.67; 95% CI 5.41 to 38.89). This risk increased to 50-fold in women from families with <jats:italic>BRCA1<\/jats:italic> mutations (RR 50.00; 95% CI 26.62 to 85.50). No association was found for women in families tested negative for <jats:italic>BRCA1\/2<\/jats:italic>, where there was 1 observed invasive ovarian cancer in 1613 women when 2.74 were expected (RR 0.37; 95% CI 0.01 to 2.03). There was no association with ovarian cancer in families untested for <jats:italic>BRCA1\/2<\/jats:italic> (RR 0.99; 95% CI 0.45 to 1.88).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>This study showed no increased risk of ovarian cancer in families that tested negative for <jats:italic>BRCA1\/2<\/jats:italic> or were untested. These data help counselling women from <jats:italic>BRCA1\/2<\/jats:italic> negative families with breast cancer that their risk of invasive ovarian cancer is not higher than the general population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jmedgenet-2013-101607","type":"journal-article","created":{"date-parts":[[2013,3,28]],"date-time":"2013-03-28T20:51:15Z","timestamp":1364503875000},"page":"368-372","source":"Crossref","is-referenced-by-count":24,"title":["Ovarian cancer among 8005 women from a breast cancer family history clinic: no increased risk of invasive ovarian cancer in families testing negative for <i>BRCA1<\/i> and <i>BRCA2<\/i>"],"prefix":"10.1136","volume":"50","author":[{"given":"Sarah Louise","family":"Ingham","sequence":"first","affiliation":[{"name":"Centre for Health Informatics, Institute of Population Health, The University of Manchester, Manchester, UK"},{"name":"Department of Genetic Medicine, The University of Manchester, Manchester Academic Health Science Centre, St Mary's Hospital, Central Manchester Hospitals Foundation Trust, Manchester, UK"},{"name":"Genesis Prevention Centre, University Hospital of South Manchester, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Warwick","sequence":"additional","affiliation":[{"name":"Imperial Clinical Trials Unit, Faculty of Medicine, School of Public Health, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain","family":"Buchan","sequence":"additional","affiliation":[{"name":"Centre for Health Informatics, Institute of Population Health, The University of Manchester, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Sahin","sequence":"additional","affiliation":[{"name":"Genesis Prevention Centre, University Hospital of South Manchester, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"O'Hara","sequence":"additional","affiliation":[{"name":"NWCIS, The Palatine Centre, Christie Hospital, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Moran","sequence":"additional","affiliation":[{"name":"NWCIS, The Palatine Centre, Christie Hospital, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Howell","sequence":"additional","affiliation":[{"name":"Genesis Prevention Centre, University Hospital of South Manchester, Manchester, UK"},{"name":"Department of Medical Oncology Manchester, Christie Hospital, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D Gareth","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Genetic Medicine, The University of Manchester, Manchester Academic Health Science Centre, St Mary's Hospital, Central Manchester Hospitals Foundation Trust, Manchester, UK"},{"name":"Genesis Prevention Centre, University Hospital of South Manchester, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2013,3,28]]},"reference":[{"key":"2025100521543032000_50.6.368.1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7545954"},{"key":"2025100521543032000_50.6.368.2","doi-asserted-by":"publisher","DOI":"10.1038\/378789a0"},{"key":"2025100521543032000_50.6.368.3","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/94.16.1221"},{"key":"2025100521543032000_50.6.368.4","first-page":"329","article-title":"Variation in BRCA1 cancer risks by mutation position","volume":"11","author":"Thompson","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2025100521543032000_50.6.368.5","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-8-155"},{"key":"2025100521543032000_50.6.368.6","doi-asserted-by":"publisher","DOI":"10.1086\/301749"},{"key":"2025100521543032000_50.6.368.7","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.15.1310"},{"key":"2025100521543032000_50.6.368.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91578-4"},{"key":"2025100521543032000_50.6.368.9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199705153362001"},{"key":"2025100521543032000_50.6.368.10","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.14.1241"},{"key":"2025100521543032000_50.6.368.11","first-page":"741","article-title":"Population-based estimate of the average age-specific cumulative risk of breast cancer for a defined set of protein-truncating mutations in BRCA1 and BRCA2. 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