{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:36:42Z","timestamp":1777401402716,"version":"3.51.4"},"reference-count":25,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Med Genet"],"accepted":{"date-parts":[[2023,9,26]]},"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Surveillance for pancreatic ductal adenocarcinoma (PDAC) is recommended for high-risk individuals with genetic variants in PDAC-associated genes and\/or family history. Surveillance uptake and adherence may depend on the perception of PDAC risk and cancer worry. We aimed to determine PDAC risk perception in at-risk individuals and assess factors associated with PDAC surveillance uptake.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>At-risk individuals identified from a prospective academic registry were sent a survey electronically. PDAC risk perception, cancer worry and surveillance uptake were surveyed. Factors associated with increased risk perception and surveillance were assessed. Five-year PDAC risk was calculated using the PancPRO risk assessment model, and correlation with subjective risk assessment was assessed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The overall survey response rate was 34% (279\/816). The median perceived PDAC risk was twofold (IQR 1\u20134) above respondents\u2019 estimates of general population risk. Factors significantly associated with higher perceived PDAC risk included non-Hispanic white race, post-graduate education level, PDAC-affected first-degree relative, genetic variants and lack of personal cancer history. Cancer worry had a very weak correlation across PDAC risk estimates (r=0.16). No correlation between perceived PDAC risk and 5-year calculated PDAC risk was found. Older age, having a first-degree relative with PDAC, meeting with a medical provider about PDAC cancer risk and awareness of surveillance modalities were significant predictors of undergoing PDAC surveillance.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Individuals at risk for PDAC do not report risk perception that correlates with calculated risk. This presents an opportunity for counselling of at-risk patients to individualise management and improve surveillance uptake for eligible individuals.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jmg-2023-109539","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T13:21:58Z","timestamp":1697635318000},"page":"270-275","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Risk perception and surveillance uptake in individuals at increased risk for pancreatic ductal adenocarcinoma"],"prefix":"10.1136","volume":"61","author":[{"given":"Denis","family":"Nguyen","sequence":"first","affiliation":[{"name":"Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1724-2164","authenticated-orcid":false,"given":"Ophir","family":"Gilad","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Chicago, Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9927-9739","authenticated-orcid":false,"given":"Christine M","family":"Drogan","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Chicago, Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoe","family":"Eilers","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Chicago, Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanhong","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, University of Chicago, Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia S","family":"Kupfer","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Chicago, Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,10,18]]},"reference":[{"key":"2025101713140026000_61.3.270.1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21708"},{"key":"2025101713140026000_61.3.270.2","unstructured":"Pancreatic cancer \u2014 cancer STAT facts. 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Perceived risk and health protective behavior: cancer screening and cancer prevention. In: Baum A , Revenson TA , Singer JE , eds. Handbook of health psychology. Lawrence Erlbaum Associates, 2001: 727\u201346. 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