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The investigation into the pathogenesis of DMD has increasingly converged on the role of histone modifications within the broader context of epigenetic regulation. These modifications, including histone acetylation, methylation and phosphorylation, are catalysed by specific enzymes and play a critical role in gene expression. This article provides an overview of the histone modifications occurring in DMD and analyses the research progress and potential of different types of histone modifications in DMD due to changes in cellular signalling for muscle regeneration, to provide new insights into diagnostic and therapeutic options for DMD.<\/jats:p>","DOI":"10.1136\/jmg-2024-110045","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T18:55:14Z","timestamp":1727376914000},"page":"1003-1010","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Histone modifications in Duchenne muscular dystrophy: pathogenesis insights and therapeutic implications"],"prefix":"10.1136","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0958-5199","authenticated-orcid":false,"given":"Yanning","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Cell Biology and Genetics, School of Basic Medical 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