{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T23:09:28Z","timestamp":1772492968192,"version":"3.50.1"},"reference-count":30,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1973,6]]},"abstract":"<jats:p>Haemolytic favism is a severe, acute anaemia which occurs in glucose-6-phosphate dehydrogenase deficient individuals, usually following the ingestion of <jats:italic>Vicia faba<\/jats:italic> seeds. Current interest is focused on the nature of the active substances of <jats:italic>Vicia faba<\/jats:italic> and on the causes of the varying susceptibility among G6PD-deficient individuals to episodes of severe haemolysis.<\/jats:p>\n               <jats:p>The results of experiments <jats:italic>in vitro<\/jats:italic> favour the hypothesis that <jats:italic>Vicia faba<\/jats:italic> contains several active substances which may act in a synergistic way.<\/jats:p>\n               <jats:p>Red cell acid phosphatase and thalassaemia genes appear to play a remarkable role in conditioning the susceptibility to severe haemolysis in G6PD-deficient subjects.<\/jats:p>\n               <jats:p>In addition to erythrocyte enzymes and to enzymes which intervene in the absorption and metabolism of the active substances of <jats:italic>Vicia faba,<\/jats:italic> another field for future investigations may be that of plasma factors which influence the stability of reduced glutathione in the red cells.<\/jats:p>","DOI":"10.1136\/jmg.10.2.154","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T14:50:51Z","timestamp":1226328651000},"page":"154-157","source":"Crossref","is-referenced-by-count":11,"title":["Favism: Current Problems and Investigations"],"prefix":"10.1136","volume":"10","author":[{"given":"E.","family":"Bottini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1973,6,1]]},"reference":[{"key":"ref_1","article-title":"Indagini genetiche sul la predisposizione al favismo. 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