{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T21:40:04Z","timestamp":1760737204274,"version":"build-2065373602"},"reference-count":26,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1975,6]]},"abstract":"<jats:p>The clinical and haematological findings in 19 Liberians probably homozygous for beta thalassaemia are described. The haemoglobin patterns were similar with Hb F levels in the 30-50% range and a raised level of Hb A2 and, although the clinical severity varied widely, over half the cases were symptomless and even the more severely affected ones showed a milder picture than that found in Mediterranean races. Haemoglobin-synthesis studies carried out on three homozygotes and two heterozygotes indicated a variable degree of globin-chain imbalance. The reasons for the mild course of the disease in Liberians and other African races are discussed; it is likely that the beta-thalassaemia genes in these populations are different from those in other racial groups. It is noted that all persons in this study belong to tribes which have a low incidence of the sickle-cell gene.<\/jats:p>","DOI":"10.1136\/jmg.12.2.165","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T14:50:51Z","timestamp":1226328651000},"page":"165-173","source":"Crossref","is-referenced-by-count":14,"title":["Homozygous beta thalassaemia in Liberia."],"prefix":"10.1136","volume":"12","author":[{"given":"M C","family":"Willcox","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D J","family":"Weatherall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J B","family":"Clegg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1975,6,1]]},"reference":[{"key":"ref_1","first-page":"857","article-title":"Homozygous beta thalassemia in American blacks: The problem of mild thalassemia","volume":"81","author":"Braverman, A.S.; McCurdy, P.R.; Manos, O.; Sherman, A.","year":"1973","unstructured":"Braverman, A. S., McCurdy, P. R., Manos, O., and Sherman, A. (1973). Homozygous beta thalassemia in American blacks: The problem of mild thalassemia. Journal of Laboratory and Clinical Medicine, 81, 857-866.","journal-title":"Journal of Laboratory and Clinical Medicine"},{"key":"ref_2","first-page":"356","article-title":"Probably homozygous beta thalassemia in a Negro child","volume":"120","year":"1970","unstructured":"Crouch, E. R., Jr., Maurer, H. M., and Valdes, 0. S. (1970). Probably homozygous beta thalassemia in a Negro child. American Journal of Diseases of Children, 120, 356-359.","journal-title":"American Journal of Diseases of Children"},{"key":"ref_3","article-title":"Practical Haematology","author":"Dacie, J.V.; Lewis, S.M.","year":"1970","unstructured":"Dacie, J. V. and Lewis, S. M. (1970). Practical Haematology, 4th ed. 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