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The relation of the observed tetraploidy to the increased risk of such patients to develop abnormal growths and cancer has not been established. The increased tetraploidy should be of value in identifying the presence of the gene for the Gardner syndrome in high risk families.<\/jats:p>","DOI":"10.1136\/jmg.13.1.52","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T14:50:51Z","timestamp":1226328651000},"page":"52-56","source":"Crossref","is-referenced-by-count":40,"title":["The Gardner syndrome: increased tetraploidy in cultured skin fibroblast."],"prefix":"10.1136","volume":"13","author":[{"given":"B S","family":"Danes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1976,2,1]]},"reference":[{"key":"ref_1","article-title":"Zur Frage der Entstehung maligner Tumorer. G. Fisher, Jena","author":"Boveri, T.","year":"1914","unstructured":"Boveri, T. (1914). Zur Frage der Entstehung maligner Tumorer. G. Fisher, Jena."},{"key":"ref_2","first-page":"63","article-title":"Human chromosome complements in normal somatic cells in culture","volume":"11","author":"Chu, E.H.Y.; Giles, N.H.","year":"1959","unstructured":"Chu, E. H. Y. and Giles, N. H. (1959). Human chromosome complements in normal somatic cells in culture. American J'ournal of Human Genetics, 11, 63-79.","journal-title":"American J'ournal of Human Genetics"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1084\/jem.129.4.775","article-title":"Cystic fibrosis of the pancreas. A study in cell culture","volume":"129","author":"Danes, B.S.; Bearn, A.G.","year":"1969","unstructured":"Danes, B. S. and Bearn, A. G. (1969). Cystic fibrosis of the pancreas. A study in cell culture. 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