{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T17:40:01Z","timestamp":1760722801987,"version":"build-2065373602"},"reference-count":16,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1976,6]]},"abstract":"<jats:p>A study of 1045 twin gestations with regard to known or likely zygosity and the incidence of pre-eclampsia\/eclampsia failed to reveal differences between known dizygous twins and like-sex 'presumed' and 'estimated' monozygous twins except in the 'estimated' data for multigravidae. There was a threefold increase in the incidence for twins as opposed to singleton pregnancies. These results are discussed in relation to increased conceptus-mother antigenic differences. It is suggested that the risk of gestosis in twin pregnancy involves more than a summation of that operating in two singleton pregnancies.<\/jats:p>","DOI":"10.1136\/jmg.13.3.208","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T14:50:51Z","timestamp":1226328651000},"page":"208-211","source":"Crossref","is-referenced-by-count":32,"title":["Pre-eclampsia\/eclampsia in twin pregnancies."],"prefix":"10.1136","volume":"13","author":[{"given":"A","family":"McFarlane","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J S","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1976,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/S0140-6736(61)91196-5","article-title":"Long term effect of pre-eclampsia in blood pressure","volume":"2","author":"Adams, E.M.; MacGillivray, I.","year":"1961","unstructured":"Adams, E. M. and MacGillivray, I. (1961). Long term effect of pre-eclampsia in blood pressure. Lancet, 2, 1373-1375.","journal-title":"Lancet"},{"key":"ref_2","first-page":"165","article-title":"The placenta of multiple pregnancy. In The Pathology of the Human Placenta","author":"Benirschke, K.; Driscoll, S.G.","year":"1967","unstructured":"Benirschke, K. and Driscoll, S. G. (1967). The placenta of multiple pregnancy. In The Pathology of the Human Placenta, p. 165. Springer-Verlag, Berlin, Heidelberg New York."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1177\/003591576806100314","article-title":"The Birmingham twin survey","volume":"61","author":"Cameron, A.H.","year":"1968","unstructured":"Cameron, A. H. (1968). The Birmingham twin survey. Proceedings of the Royal Society of Medicine, 61, 229-234.","journal-title":"Proceedings of the Royal Society of Medicine"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/genetics\/33.3.263","article-title":"The frequencies of twins, relative to age of mothers, in American populations","volume":"33","author":"Enders, T.; Stern, C.","year":"1948","unstructured":"Enders, T. and Stern, C. (1948). The frequencies of twins, relative to age of mothers, in American populations. Genetics, 33, 263.","journal-title":"Genetics"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/232277a0","article-title":"Excess of like-sexed pairs of dizygotic twins","volume":"232","author":"James, W.H.","year":"1971","unstructured":"James, W. H. (1971). Excess of like-sexed pairs of dizygotic twins. Nature (London), 232, 277-278.","journal-title":"Nature (London)"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1469-1809.1946.tb02351.x","article-title":"Genetical antigenic incompatibility as a possible cause of the toxaemias occurring late in pregnancy","volume":"13","author":"Kalmus, H.","year":"1946","unstructured":"Kalmus, H. (1946). Genetical antigenic incompatibility as a possible cause of the toxaemias occurring late in pregnancy. Annals of Eugenics, 13, 146-149.","journal-title":"Annals of Eugenics"},{"issue":"30","key":"ref_7","first-page":"37","article-title":"Pathological anatomy of acute hypertension of pregnancy","volume":"29","author":"McCartney, C.P.","year":"1964","unstructured":"McCartney, C. P. (1964). Pathological anatomy of acute hypertension of pregnancy. Circulation, 29 and 30, Suppl. 11, 37-42.","journal-title":"Circulation"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1542\/peds.33.4.546","article-title":"Fetal and neonatal development of twins","volume":"33","author":"Naeye, R.L.","year":"1964","unstructured":"Naeye, R. L. (1964). Fetal and neonatal development of twins. Pediatrics, 33, 546-553.","journal-title":"Pediatrics"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/j.1471-0528.1970.tb03557.x","article-title":"The determination of zygosity-a study of 608 pairs born in Aberdeen","volume":"77","author":"Nylander, P.P.S.","year":"1970","unstructured":"Nylander, P. P. S. (1970). The determination of zygosity-a study of 608 pairs born in Aberdeen. Journal of Obstetrics and Gynaecology of the British Commonwealth, 77, 506-510.","journal-title":"Journal of Obstetrics and Gynaecology of the British Commonwealth"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1017\/S1120962300023337","article-title":"Hypothesis of an ovular regulation of pregnancy weight-gain","volume":"23","author":"Papiernik, E.; Gerard, L.; Hult, A.M.; Schneider, L.","year":"1974","unstructured":"Papiernik, E., Gerard, L., Hult, A. M., and Schneider, L. (1974). Hypothesis of an ovular regulation of pregnancy weight-gain. Acta Geneticae Medicae et Gemellologiae, 23, 56.","journal-title":"Acta Geneticae Medicae et Gemellologiae"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1469-1809.1946.tb02350.x","article-title":"On the familial appearances of maternal and fetal incompatibility","volume":"13","author":"Penrose, L.S.","year":"1946","unstructured":"Penrose, L. S. (1946). On the familial appearances of maternal and fetal incompatibility. Annals of Eugenics, 13, 141-145.","journal-title":"Annals of Eugenics"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/S0140-6736(58)91192-9","article-title":"The aetiology, incidence and heredity of pre-eclamptic toxaemia of pregnancy","volume":"1","author":"Platt, R.; Stewart, A.E.; Emery, E.W.","year":"1958","unstructured":"Platt, R., Stewart, A. E., and Emery, E. W. (1958). The aetiology, incidence and heredity of pre-eclamptic toxaemia of pregnancy. Lancet, 1, 552-556.","journal-title":"Lancet"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/S0140-6736(55)92793-8","article-title":"Do transplacental hormones cause eclampsia ?","volume":"2","author":"Salzmann, K.D.","year":"1955","unstructured":"Salzmann, K. D. (1955). Do transplacental hormones cause eclampsia ? Lancet, 2, 953-956.","journal-title":"Lancet"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1469-1809.1971.tb00255.x","article-title":"The number of pregnancies prior to the birth of twins","volume":"34","author":"Selvin, S.","year":"1971","unstructured":"Selvin, S. (1971). The number of pregnancies prior to the birth of twins. Annals of Human Genetics, 34, 427-429.","journal-title":"Annals of Human Genetics"},{"key":"ref_15","first-page":"1286","article-title":"Contribution of fetal,\/maternal incompatibility to aetiology of pre-eclamptic toxaemia","volume":"2","author":"Stevenson, A.C.; Davison, B.C.C.; Say, B.; Ustuoplu, S.; Lya, D.; Toppozoda, H.K.","year":"1971","unstructured":"Stevenson, A. C., Davison, B. C. C., Say, B., Ustuoplu, S., Lya, D., and Toppozoda, H. K. (1971). Contribution of fetal,\/maternal incompatibility to aetiology of pre-eclamptic toxaemia. Lancet, 2, 1286-1289.","journal-title":"Lancet"},{"key":"ref_16","first-page":"187188","article-title":"Sex ratio of newborns: preponderance of males in toxaemia of pregnancy","volume":"170","author":"Toivanen, P.; Hirvonen, T.","year":"1970","unstructured":"Toivanen, P. and Hirvonen, T. (1970). Sex ratio of newborns: preponderance of males in toxaemia of pregnancy. Science, 170, 187188.","journal-title":"Science"}],"container-title":["Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jmg.13.3.208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T17:15:27Z","timestamp":1760721327000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmg.bmj.com\/lookup\/doi\/10.1136\/jmg.13.3.208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,6]]},"references-count":16,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1976,6,1]]},"published-print":{"date-parts":[[1976,6]]}},"alternative-id":["10.1136\/jmg.13.3.208"],"URL":"https:\/\/doi.org\/10.1136\/jmg.13.3.208","relation":{},"ISSN":["0022-2593","1468-6244"],"issn-type":[{"type":"print","value":"0022-2593"},{"type":"electronic","value":"1468-6244"}],"subject":[],"published":{"date-parts":[[1976,6]]}}}