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This observation stresses the phenotypic variability of the EEC syndrome, which in most cases is inherited as an autosomal dominant with reduced penetrance.<\/jats:p>","DOI":"10.1136\/jmg.13.4.281","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T14:50:51Z","timestamp":1226328651000},"page":"281-284","source":"Crossref","is-referenced-by-count":47,"title":["Ectrodactyly-ectodermal dysplasia-clefting (EEC) syndrome: dominant inheritance and variable expression."],"prefix":"10.1136","volume":"13","author":[{"given":"V B","family":"Penchaszadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T C","family":"de Negrotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1976,8,1]]},"reference":[{"key":"ref_1","first-page":"43","article-title":"The ectrodactyly-ectodermal dysplasia-clefting (EEC) syndrome","volume":"3","author":"Bixler, D.; Spivack, J.; Bennett, J.; Christian, J.C.","year":"1971","unstructured":"Bixler, D., Spivack, J., Bennett, J., and Christian, J. 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A., Haase, W., and Passarge, E. (1970). Association of ectrodactyly, ectodermal dysplasia and cleft lip-palate. American Journal of Diseases of Children, 120, 160-163.","journal-title":"American Journal of Diseases of Children"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1097\/00006534-196312000-00006","article-title":"The syndrome of cleft lip, cleft palate and lobster claw deformities of hands and feet","volume":"32","author":"Walker, J.C.; Clodius, L.","year":"1963","unstructured":"Walker, J. C. and Clodius, L. (1963). The syndrome of cleft lip, cleft palate and lobster claw deformities of hands and feet. Plastic and Reconstructive Surgery, 32, 627-636.","journal-title":"Plastic and Reconstructive Surgery"}],"container-title":["Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jmg.13.4.281","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T22:16:32Z","timestamp":1760739392000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmg.bmj.com\/lookup\/doi\/10.1136\/jmg.13.4.281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,8]]},"references-count":8,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1976,8,1]]},"published-print":{"date-parts":[[1976,8]]}},"alternative-id":["10.1136\/jmg.13.4.281"],"URL":"https:\/\/doi.org\/10.1136\/jmg.13.4.281","relation":{},"ISSN":["0022-2593","1468-6244"],"issn-type":[{"value":"0022-2593","type":"print"},{"value":"1468-6244","type":"electronic"}],"subject":[],"published":{"date-parts":[[1976,8]]}}}