{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T18:21:30Z","timestamp":1785781290077,"version":"3.56.0"},"reference-count":8,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1977,6]]},"abstract":"<jats:p>We present a pair of dizygotic twins with different abnormal karyotypes. The chromosome anomaly is a sexual aneuploidy in both cases: 48,XXXXY in one, 47,XXY in the second. The origin of the chromosomal anomaly and the hypothetical relation between sexual aneuploidy and twinning is discussed. It is concluded that further studies in twins are necessary to prove the not yet solved problems of non-disjunction and double ovulation.<\/jats:p>","DOI":"10.1136\/jmg.14.3.226","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T14:50:51Z","timestamp":1226328651000},"page":"226-228","source":"Crossref","is-referenced-by-count":4,"title":["Twins with nonconcordant sexual aneuploidy."],"prefix":"10.1136","volume":"14","author":[{"given":"J M","family":"Garcia-Sagredo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Merello-Godino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"San Roman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1977,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/S0140-6736(58)91684-2","article-title":"Chromatin-positive Klinefelter's syndrome (primary microrchidism) in a mentaldeficiency hospital","volume":"1","author":"Ferguson-Smith, M.A.","year":"1958","unstructured":"Ferguson-Smith, M. A. (1958). Chromatin-positive Klinefelter's syndrome (primary microrchidism) in a mentaldeficiency hospital. Lancet, 1, 928-931.","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/S0140-6736(62)92863-5","article-title":"Twinning in Klinefelter's syndrome","volume":"1","author":"Hoefnagel, D.; Benirschke, K.","year":"1962","unstructured":"Hoefnagel, D., and Benirschke, K. (1962). Twinning in Klinefelter's syndrome. Lancet, 1, 1282.","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1136\/jmg.3.2.114","article-title":"Twins in sibships with Klinefelter's syndrome","volume":"3","author":"Nielsen, J.","year":"1966","unstructured":"Nielsen, J. (1966). Twins in sibships with Klinefelter's syndrome. Journal of Medical Genetics. 3, 114-116.","journal-title":"Journal of Medical Genetics"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1017\/S1120962300014761","article-title":"Twins in sibships with Klinefelter's syndrome and the XYY syndrome","volume":"19","author":"Nielsen, J.","year":"1970","unstructured":"Nielsen, J. (1970). Twins in sibships with Klinefelter's syndrome and the XYY syndrome. Acta Geneticae Medicae et Gemellologiae, 19, 399-403.","journal-title":"Acta Geneticae Medicae et Gemellologiae"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S0140-6736(67)91237-8","article-title":"Finger-print pattern and the sex chromosomes","volume":"1","author":"Penrose, L.S.","year":"1967","unstructured":"Penrose, L. S. (1967). Finger-print pattern and the sex chromosomes. Lancet, 1, 298-300.","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/oxfordjournals.bmb.a070677","article-title":"Xg and sex-chromosome abnormalities","volume":"25","author":"Race, R.R.; Sanger, R.","year":"1969","unstructured":"Race, R. R., and Sanger, R. (1969). Xg and sex-chromosome abnormalities. British Medical Bulletin, 25, 99-103.","journal-title":"British Medical Bulletin"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1136\/jmg.5.3.173","article-title":"Genetic characteristics of families of XO and XXY patients, including evidence of source of X chromosomes in 7 aneuploidic patients","volume":"5","author":"Soltan, H.C.","year":"1968","unstructured":"Soltan, H. C. (1968). Genetic characteristics of families of XO and XXY patients, including evidence of source of X chromosomes in 7 aneuploidic patients. Journal of Medical Genetics, 5, 173-180.","journal-title":"Journal of Medical Genetics"},{"key":"ref_8","first-page":"73","article-title":"L'influence de l'age parental sur la production de l'anomalie XXXXY","volume":"22","author":"Tumba, A.","year":"1974","unstructured":"Tumba, A. (1974). L'influence de l'age parental sur la production de l'anomalie XXXXY. Journal de GCnetique Humaine, 22, 73-97.","journal-title":"Journal de GCnetique Humaine"}],"container-title":["Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jmg.14.3.226","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T18:45:56Z","timestamp":1759689956000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmg.bmj.com\/lookup\/doi\/10.1136\/jmg.14.3.226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,6]]},"references-count":8,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1977,6,1]]},"published-print":{"date-parts":[[1977,6]]}},"alternative-id":["10.1136\/jmg.14.3.226"],"URL":"https:\/\/doi.org\/10.1136\/jmg.14.3.226","relation":{},"ISSN":["0022-2593","1468-6244"],"issn-type":[{"value":"0022-2593","type":"print"},{"value":"1468-6244","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,6]]}}}