{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T09:34:36Z","timestamp":1777109676530,"version":"3.51.4"},"reference-count":20,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1977,10]]},"abstract":"<jats:p>Placental lead levels were studied in a series of Birmingham births classified by stillbirth, neonatal death, or survival beyond one week. There was an appreciable range of lead levels even in normal births (0.15-3.56 microgram\/g) but nevertheless average results showed a pronounced excess of lead in those who failed to survive both birth and the neonatal period. There was no association of placental lead with impaired birthweight among survivors but, in common with other authors, we noted a seasonal variation. The placentae from Indian women had similar lead levels to those from European women and lower values were found in the normal sibs of stillbirths and neonatal deaths. The possibility is discussed that under conditions of impaired fetal health in late pregnancy the placenta may concentrate lead.<\/jats:p>","DOI":"10.1136\/jmg.14.5.339","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T14:50:51Z","timestamp":1226328651000},"page":"339-345","source":"Crossref","is-referenced-by-count":59,"title":["Lead levels in human placentae from normal and malformed births."],"prefix":"10.1136","volume":"14","author":[{"given":"D G","family":"Wibberley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A K","family":"Khera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J H","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D I","family":"Rushton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1977,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/0013-9351(74)90063-2","article-title":"Utility of placental tissue as an indicator of trace element exposure to adult and fetus","volume":"8","author":"Baglan, R.J.; Brill, A.B.; Schulert, A.; Wilson, D.; Larsen, K.; Dyer, N.; Mansour, M.; Schaffner, L.; Hoffman, L.; J, Davies","year":"1974","unstructured":"Baglan, R. J., Brill, A. B., Schulert, A., Wilson, D., Larsen, K., Dyer, N., Mansour, M., Schaffner, L., Hoffman, L., and Davies J. (1974). Utility of placental tissue as an indicator of trace element exposure to adult and fetus. Environmental Research, 8, 64-70.","journal-title":"Environmental Research"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1126\/science.181.4096.230","article-title":"Methylmercury poisoning in Iraq","volume":"181","author":"Bakir, F.; Damluji, L.; Amin-Zaki, M.; Murtadha, M.; Khalidi, A.; Al-Rawi, N.Y.; Tikriti, S.; Dhahir, H.I.; Clarkson, T.W.; Smith, J.C.; Doherty, R.A.","year":"1973","unstructured":"Bakir, F., Damluji, L., Amin-Zaki, M., Murtadha, M., Khalidi, A., Al-Rawi, N. Y., Tikriti, S., Dhahir, H. I., Clarkson, T. W., Smith, J. C., and Doherty, R. A. (1973). Methylmercury poisoning in Iraq. Science, 181, 230-241.","journal-title":"Science"},{"key":"ref_3","first-page":"149","article-title":"Sample preparation using tissue solubilization by Soluene-350TM for lead determinations by graphite furnace atomic absorption spectrophotometry. Atomic Absorption Newsletter (U. S","volume":"14","author":"Barlow, P.J.; Khera, A.K.","year":"1975","unstructured":"Barlow, P. J., and Khera, A. K. (1975). Sample preparation using tissue solubilization by Soluene-350TM for lead determinations by graphite furnace atomic absorption spectrophotometry. Atomic Absorption Newsletter (U.S.A.), 14, 149-150.","journal-title":"A.)"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1136\/bmj.1.5850.402","article-title":"Lead intoxication in children in Birmingham","volume":"1","author":"Betts, P.R.; Astley, R.; Raine, D.N.","year":"1973","unstructured":"Betts, P. R., Astley, R., and Raine, D. N. (1973). Lead intoxication in children in Birmingham. British Medical Journal, 1, 402-406.","journal-title":"British Medical Journal"},{"key":"ref_5","article-title":"Lead Poisoning","author":"Cantarow, A.; Trumper, M.","year":"1944","unstructured":"Cantarow, A., and Trumper, M. (1944). Lead Poisoning. Williams and Wilkins, Baltimore."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1080\/00039896.1973.10666344","article-title":"Pollutant burdens and biological response","volume":"27","author":"Collucci, A.V.; Hammer, D.I.; Williams, M.E.; Hinners, T.A.; Pinkerton, C.; Kent, J.L.; Love, G.J.","year":"1973","unstructured":"Collucci, A. V., Hammer, D. I., Williams, M. E., Hinners, T. A., Pinkerton, C., Kent, J. L., and Love, G. J. (1973). Pollutant burdens and biological response. Archives of Environmental Health, 27, 151-154.","journal-title":"Archives of Environmental Health"},{"key":"ref_7","first-page":"354","article-title":"Study of seasonal variations in nine cations of normal term placentas","volume":"92","author":"Dawson, E.B.; Croft, H.A.; Clark, R.R.; McGanity, W.J.","year":"1968","unstructured":"Dawson, E. B., Croft, H. A., Clark, R. R., and McGanity, W. J. (1968). Study of seasonal variations in nine cations of normal term placentas. American Journal of Obstetrics and Gynecology, 92, 354-361.","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"ref_8","first-page":"303306","article-title":"Uber die Ablagerung von Blei in den Verkalkungen der menschlichen","volume":"213","author":"Einbrodt, H.J.; Schiereck, F.W.; Kinny, H.","year":"1973","unstructured":"Einbrodt, H. J., Schiereck, F. W., and Kinny, H. (1973). Uber die Ablagerung von Blei in den Verkalkungen der menschlichen Placenta. Archiv fur Gynakologie, 213, 303306."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/BF01903893","article-title":"The synteratogenic effect of lead and cadmium","volume":"25","author":"Ferm, V.H.","year":"1969","unstructured":"Ferm, V. H. (1969). The synteratogenic effect of lead and cadmium. Experientia, 25, 56-57.","journal-title":"Experientia"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/0014-4800(67)90030-5","article-title":"Developmental malformations resulting from the administration of lead salts","volume":"7","author":"Ferm, V.H.; Carpenter, S.J.","year":"1967","unstructured":"Ferm, V. H., and Carpenter, S. J. (1967). Developmental malformations resulting from the administration of lead salts. Experimental Molecular Pathology, 7, 208-213.","journal-title":"Experimental Molecular Pathology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1080\/00039896.1969.10665508","article-title":"Interrelationships of selenium, cadmium and arsenic in mammalian teratogenesis","volume":"18","author":"Holberg, R.E.; Ferm, V.H.","year":"1969","unstructured":"Holberg, R. E., and Ferm, V. H. (1969). Interrelationships of selenium, cadmium and arsenic in mammalian teratogenesis. Archives of Environmental Health, 18, 873-877.","journal-title":"Archives of Environmental Health"},{"key":"ref_12","first-page":"41","article-title":"Studies on the industrial lead poisoning","volume":"5","author":"Horiuchi, K.; Horiguchi, S.; Suekane, M.","year":"1959","unstructured":"Horiuchi, K., Horiguchi, S., and Suekane, M. (1959). Studies on the industrial lead poisoning. Osaka City Medical Journal, 5, 41-70.","journal-title":"Osaka City Medical Journal"},{"key":"ref_13","first-page":"340","article-title":"Some analytical problems concerning trace-metal analysis in human placentae. Proceedings of the Analytical Division of the","volume":"13","author":"Khera, A.K.; Wibberley, D.G.","year":"1976","unstructured":"Khera, A. K., and Wibberley, D. G. (1976). Some analytical problems concerning trace-metal analysis in human placentae. Proceedings of the Analytical Division of the Chemical Society (U.K.), 13, 340-342.","journal-title":"Chemical Society (U. K.)"},{"key":"ref_14","series-title":"Proceedings of the International Symposium on Environmental Health Aspects of Lead","first-page":"333","article-title":"Lead levels in infant food sold on the Italian market","author":"Lanzola, E.; Allegrini, M.; Breuer, F.","year":"1973","unstructured":"Lanzola, E., Allegrini, M., and Breuer, F. (1973). Lead levels in infant food sold on the Italian market. 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International Archives of Occupational And Environmental Health, 36, 19-27.","journal-title":"International Archives of Occupational And Environmental Health"},{"key":"ref_19","first-page":"117","article-title":"Sub-clinical Lead Poisoning","author":"Waldron, H.A.; Stofen, D.","year":"1974","unstructured":"Waldron, H. A., and Stofen, D. (1974). Sub-clinical Lead Poisoning, p. 117. Academic Press, London."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1136\/bmj.1.5584.117-a","article-title":"Lead poisoning from eye cosmetic","volume":"1","author":"Warley, M.A.; Blackledge, P.; O'Gorman, P.","year":"1968","unstructured":"Warley, M. A., Blackledge, P., and O'Gorman, P. (1968). Lead poisoning from eye cosmetic. 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