{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T02:44:24Z","timestamp":1777430664978,"version":"3.51.4"},"reference-count":11,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1978,8]]},"abstract":"<jats:p>The combined use of alphafetoprotein (AFP) measurement and amniotic fluid cell morphology was assessed in 217 pregnancies with normal outcome (including 12 where an anterior placenta was traversed), and 52 where there was a fetal defect (25 cases of anencephaly, 21 of open spina bifida, 2 of exomphalos, 2 of urogenital atresia, and 2 of intrauterine death). In each case maternal serum and amniotic fluid AFP was measured. Total, viable, and rapidly adherent cells were counted and amniotic fluid cell morphology was examined. On the basis of this experience a scheme is suggested for more precise antenatal diagnosis of fetal abnormalities.<\/jats:p>","DOI":"10.1136\/jmg.15.4.262","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T14:50:51Z","timestamp":1226328651000},"page":"262-270","source":"Crossref","is-referenced-by-count":45,"title":["Combined use of alphafetoprotein and amniotic fluid cell morphology in early prenatal diagnosis of fetal abnormalities."],"prefix":"10.1136","volume":"15","author":[{"given":"C","family":"Gosden","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D J","family":"Brock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1978,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1365-2362.1977.tb01637.x","article-title":"Review. Prenatal diagnosis of neural tube defects","volume":"7","author":"Brock, D.J.H.","year":"1977","unstructured":"Brock, D. J. H. (1977). Review. Prenatal diagnosis of neural tube defects. European Journal ofClinical Investigation, 7, 465-472.","journal-title":"European Journal ofClinical Investigation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0009-8981(78)90031-1","article-title":"Serum alphafetoprotein in cystic fibrosis of the pancreas","volume":"82","author":"Brock, D.J.H.; Barron, L.; Manson, J.; McCrae, W.M.","year":"1978","unstructured":"Brock, D. J. H., Barron, L., Manson, J., and McCrae, W. M. (1978). Serum alphafetoprotein in cystic fibrosis of the pancreas. Clinica Chimica Acta, 82, 101-103.","journal-title":"Clinica Chimica Acta"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1136\/bmj.2.6092.934","article-title":"Early antenatal diagnosis of small open spina bifida lesions","volume":"2","author":"Brock, D.J.H.; Gosden, C.","year":"1977","unstructured":"Brock, D. J. H., and Gosden, C. (1977a). Early antenatal diagnosis of small open spina bifida lesions. British Medical Journal, 2, 934.","journal-title":"British Medical Journal"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/S0140-6736(77)91552-5","article-title":"Are second trimester amniotic fluids being properly examined?","volume":"2","author":"Brock, D.J.H.; Gosden, C.","year":"1977","unstructured":"Brock, D. J. H., and Gosden, C. (1977b). Are second trimester amniotic fluids being properly examined? Lancet, 2, 1168-1169.","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1399-0004.1975.tb00313.x","article-title":"Amniotic fluid alphafetoprotein measurements in the early prenatal diagnosis of central nervous system disorders","volume":"7","author":"Brock, D.J.H.; Scrimgeour, J.B.; Nelson, M.M.","year":"1975","unstructured":"Brock, D. J. H., Scrimgeour, J. B., and Nelson, M. M. (1975). Amniotic fluid alphafetoprotein measurements in the early prenatal diagnosis of central nervous system disorders. Clinical Genetics, 7, 163-169.","journal-title":"Clinical Genetics"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0140-6736(72)91634-0","article-title":"Alpha-fetoprotein in the antenatal diagnosis of anencephaly and spina bifida","volume":"2","author":"Brock, D.J.H.; Sutcliffe, R.G.","year":"1972","unstructured":"Brock, D. J. H., and Sutcliffe, R. G. (1972). Alpha-fetoprotein in the antenatal diagnosis of anencephaly and spina bifida. Lancet, 2, 197-199.","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S0140-6736(77)92221-8","article-title":"Morphology of rapidly adhering amniotic fluid cells as an aid to the diagnosis of neural tube defects","volume":"1","author":"Gosden, C.M.; Brock, D.J.H.","year":"1977","unstructured":"Gosden, C. M., and Brock, D. J. H. (1977). Morphology of rapidly adhering amniotic fluid cells as an aid to the diagnosis of neural tube defects. Lancet, 1, 919-922.","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1399-0004.1977.tb00926.x","article-title":"The origin of the rapidly adhering cells found in amniotic fluids from foetuses with neural tube defects","volume":"12","author":"Gosden, C.M.; Brock, D.J.H.; Eason, P.","year":"1977","unstructured":"Gosden, C. M., Brock, D. J. H., and Eason, P. (1977). The origin of the rapidly adhering cells found in amniotic fluids from foetuses with neural tube defects. Clinical Genetics, 12, 193-201.","journal-title":"Clinical Genetics"},{"key":"ref_9","first-page":"69","article-title":"Amniotic fluid cell culture and chromosome studies. In Antenatal Diagnosis of Genetic Disease","author":"Nelson, M.M.","year":"1973","unstructured":"Nelson, M. M. (1973). Amniotic fluid cell culture and chromosome studies. In Antenatal Diagnosis of Genetic Disease, pp. 69-81. Ed. by A. E. H. Emery. Churchill Livingstone, Edinburgh."},{"key":"ref_10","first-page":"504","article-title":"Predictive value of amniotic fluid macrophages in gross","volume":"1","author":"Nelson, M.M.; Ruttiman, M.T.; Brock, D.J.H.","year":"1974","unstructured":"Nelson, M. M., Ruttiman, M. T., and Brock, D. J. H. (1974). Predictive value of amniotic fluid macrophages in gross C.N.S. defects. Lancet, 1, 504.","journal-title":"Lancet"},{"key":"ref_11","first-page":"1323","article-title":"Report of United Kingdom Collaborative Study on Alphafetoprotein in Relation to Neural Tube Defects","volume":"1","year":"1977","unstructured":"Report of United Kingdom Collaborative Study on Alphafetoprotein in Relation to Neural Tube Defects (1977). Lancet, 1, 1323-1333.","journal-title":"Lancet"}],"container-title":["Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jmg.15.4.262","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T21:53:05Z","timestamp":1760737985000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmg.bmj.com\/lookup\/doi\/10.1136\/jmg.15.4.262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,8]]},"references-count":11,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1978,8,1]]},"published-print":{"date-parts":[[1978,8]]}},"alternative-id":["10.1136\/jmg.15.4.262"],"URL":"https:\/\/doi.org\/10.1136\/jmg.15.4.262","relation":{},"ISSN":["0022-2593","1468-6244"],"issn-type":[{"value":"0022-2593","type":"print"},{"value":"1468-6244","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,8]]}}}