{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T16:06:42Z","timestamp":1775837202227,"version":"3.50.1"},"reference-count":9,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1978,10]]},"abstract":"<jats:p>The clinical and pathology findings in 2 sibs with xeroderma pigmentosum (XDP), complicated by metastatic malignant melanoma which underwent spontaneous regression, are described. The pathology of one of these patients showed features of possible spontaneous regression, namely foamy histiocytes, capillary proliferation, and a chronic inflammatory infiltrate which was devoid of malignant cells, suggesting the possibility that an immunological mechanism was at work. It was of interest that a recent review of 27 cases of spontaneous regression of metastatic melanoma since 1900 contained a patient with XDP. Adding our 2 cases, at least 10% of the spontaneous regressions of metastatic melanoma occurred in patients with XDP. This unusual association raised the question that the genotype for XDP may possibly foster control of metastatic malignant melanoma in some as yet unknown way.<\/jats:p>","DOI":"10.1136\/jmg.15.5.357","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T14:50:51Z","timestamp":1226328651000},"page":"357-362","source":"Crossref","is-referenced-by-count":17,"title":["Spontaneous regression of metastatic malignant melanoma in 2 sibs with xeroderma pigmentosum."],"prefix":"10.1136","volume":"15","author":[{"given":"H T","family":"Lynch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"3rd","given":"B C","family":"Frichot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"J L","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J F","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1978,10,1]]},"reference":[{"key":"ref_1","first-page":"28","article-title":"Clinical characteristics of the genetic variety of cutaneous melanoma in man","author":"Anderson, D.E.","year":"1971","unstructured":"Anderson, D. E. (1971). Clinical characteristics of the genetic variety of cutaneous melanoma in man. Cancer, 28,721-725.","journal-title":"Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1002\/1097-0142(197602)37:2<735::AID-CNCR2820370221>3.0.CO;2-Z","article-title":"A clinical, histologic, and immunologic study of a case of metastatic malignant melanoma undergoing spontaneous remission","volume":"37","author":"Bodurtha, A.J.; Berkelhammer, J.; Kim, Y.H.; Laucius, J.F.; Mastrangelo, M.J.","year":"1976","unstructured":"Bodurtha, A. J., Berkelhammer, J., Kim, Y. H., Laucius, J. F., and Mastrangelo, M. J. (1976). A clinical, histologic, and immunologic study of a case of metastatic malignant melanoma undergoing spontaneous remission. Cancer, 37, 735-742.","journal-title":"Cancer"},{"key":"ref_3","article-title":"Spontaneous Regression of Cancer","author":"Everson, T.C.; Cole, W.H.","year":"1966","unstructured":"Everson, T. C., and Cole, W. H. (1966). Spontaneous Regression of Cancer. Saunders, Philadelphia."},{"key":"ref_4","article-title":"Abnormal Hemoglobins in Human Populations: A Summary and Interpretation","author":"Livingstone, F.B.","year":"1967","unstructured":"Livingstone, F. B. (1967). Abnormal Hemoglobins in Human Populations: A Summary and Interpretation. Aldine, Chicago."},{"key":"ref_5","first-page":"96","article-title":"Xeroderma pigmentosum, malignant melanoma, and congenital ichthyosis","author":"Lynch, H.T.; Anderson, D.E.; Smith, Jr., J.L.; Howell, J.B.; Krush, A.S.","year":"1967","unstructured":"Lynch, H. T., Anderson, D. E., Smith, J. L., Jr., Howell, J. B., and Krush, A. S. (1967). Xeroderma pigmentosum, malignant melanoma, and congenital ichthyosis. Archives of Dermatology, 96,625-635.","journal-title":"Archives of Dermatology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/BF02586560","article-title":"Multiple primary cancer and prolonged survival: familial colon and endometrial cancer","volume":"21","author":"Lynch, H.T.; Bardawil, W.A.; Harris, R.E.; Lynch, P.M.; Guirgis, H.A.; Lynch, J.F.","year":"1978","unstructured":"Lynch, H. T., Bardawil, W. A., Harris, R. E., Lynch, P. M., Guirgis, H. A., and Lynch, J. F. (1978a). Multiple primary cancer and prolonged survival: familial colon and endometrial cancer. Diseases ofColon and Rectum, 21, 165-168.","journal-title":"Diseases ofColon and Rectum"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1136\/jmg.15.5.352","article-title":"Familial atypical multiple mole-melanoma syndrome","volume":"15","author":"Lynch, H.T.; Frichot, III, B.C.; Lynch, J.F.","year":"1978","unstructured":"Lynch, H. T., Frichot, B. C., III, and Lynch, J. F. (1978b) Familial atypical multiple mole-melanoma syndrome. Journal of Medical Genetics, 15, 352-356.","journal-title":"Journal of Medical Genetics"},{"key":"ref_8","first-page":"44","article-title":"Spontaneous regression of malignant melanoma: a review of the literature on incidence, clinical features, and possible mechanisms. Conference of Spontaneous Regression of Cancer","author":"Nathanson, L.","year":"1976","unstructured":"Nathanson, L. (1976). Spontaneous regression of malignant melanoma: a review of the literature on incidence, clinical features, and possible mechanisms. Conference of Spontaneous Regression of Cancer. NCI Monograph, 44,67-77.","journal-title":"NCI Monograph"},{"key":"ref_9","first-page":"14","article-title":"Diabetes mellitus: a thrifty genotype rendered detrimental by 'Progress'?","author":"Neel, J.V.","year":"1962","unstructured":"Neel, J. V. (1962). Diabetes mellitus: a thrifty genotype rendered detrimental by 'Progress'? American Journal ofHuman Genetics, 14,353-362.","journal-title":"American Journal ofHuman Genetics"}],"container-title":["Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jmg.15.5.357","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T05:24:00Z","timestamp":1760765040000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmg.bmj.com\/lookup\/doi\/10.1136\/jmg.15.5.357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,10]]},"references-count":9,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1978,10,1]]},"published-print":{"date-parts":[[1978,10]]}},"alternative-id":["10.1136\/jmg.15.5.357"],"URL":"https:\/\/doi.org\/10.1136\/jmg.15.5.357","relation":{},"ISSN":["0022-2593","1468-6244"],"issn-type":[{"value":"0022-2593","type":"print"},{"value":"1468-6244","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,10]]}}}