{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T19:14:59Z","timestamp":1760728499533,"version":"build-2065373602"},"reference-count":11,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1978,12]]},"abstract":"<jats:p>Two fetuses, terminated after prenatal diagnosis of aneural tube defect, had Meckel syndrome. There have now been three fetuses with this syndrome in a series of 35 terminated because of open lesions of the neural tube. It is suggested that such therapeutically aborted fetuses represent a highly selected group, among which a rare condition like Meckel syndrome will be concentrated. The need for a detailed examination of all terminated fetuses is emphasised, for the identification of such an autosomal recessive condition alters the genetic counselling for a future pregnancy.<\/jats:p>","DOI":"10.1136\/jmg.15.6.462","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T14:50:51Z","timestamp":1226328651000},"page":"462-465","source":"Crossref","is-referenced-by-count":30,"title":["Meckel syndrome and the prenatal diagnosis of neural tube defects."],"prefix":"10.1136","volume":"15","author":[{"given":"M J","family":"Seller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1978,12,1]]},"reference":[{"key":"ref_1","first-page":"1462","article-title":"Neural tube defects","volume":"294","author":"Althouse, R.; Kline, J.","year":"1976","unstructured":"Althouse, R., and Kline, J. (1976). Neural tube defects. New England Journal ofMedicine, 294, 1462.","journal-title":"New England Journal ofMedicine"},{"key":"ref_2","first-page":"11","article-title":"Prenatal diagnosis of Meckel syndrome: alphafetoprotein and beta-trace protein in amniotic fluid","author":"Chemke, J.; Miskin, A.; Rav-Acha, Z.; Porath, A.; Sagiv, M.; Katz, Z.","year":"1977","unstructured":"Chemke, J., Miskin, A., Rav-Acha, Z., Porath, A., Sagiv, M., and Katz, Z. (1977). Prenatal diagnosis of Meckel syndrome: alphafetoprotein and beta-trace protein in amniotic fluid. Clinical Genetics, 11,285-289.","journal-title":"Clinical Genetics"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1136\/jmg.13.1.9","article-title":"Congenital malformations of the central nervous system in spontaneous abortions","volume":"13","author":"Creasy, M.R.; Alberman, E.D.","year":"1976","unstructured":"Creasy, M. R., and Alberman, E. D. (1976). Congenital malformations of the central nervous system in spontaneous abortions. Journal ofMedical Genetics, 13, 9-16.","journal-title":"Journal ofMedical Genetics"},{"key":"ref_4","first-page":"1399","article-title":"Relatively high prevalence of the Meckel syndrome among Jews","volume":"9","author":"Fried, K.","year":"1973","unstructured":"Fried, K. (1973). Relatively high prevalence of the Meckel syndrome among Jews. Israel Journal ofMedical Science, 9, 1399.","journal-title":"Israel Journal ofMedical Science"},{"key":"ref_5","first-page":"294","article-title":"Etiologic heterogeneity of neural tube defects","author":"Holmes, L.B.; Driscoll, S.G.; Atkins, L.","year":"1976","unstructured":"Holmes, L. B., Driscoll, S. G., and Atkins, L. (1976). Etiologic heterogeneity of neural tube defects. New England Journal of Medicine, 294,365-369.","journal-title":"New England Journal of Medicine"},{"key":"ref_6","first-page":"49","article-title":"Prenatal diagnosis of neural tube defects. III. A re-evaluation of the alphafetoprotein assay","author":"Kimball, M.E.; Milunsky, A.; Alpert, E.","year":"1977","unstructured":"Kimball, M. E., Milunsky, A., and Alpert, E. (1977). Prenatal diagnosis of neural tube defects. III. A re-evaluation of the alphafetoprotein assay. Obstetrics and Gynecology, 49,532-536.","journal-title":"Obstetrics and Gynecology"},{"key":"ref_7","first-page":"14","article-title":"Encephalocoele, polycystic kidneys and polydactyly as an autosomal recession trait simulating certain other disorders: the Meckel syndrome. Annales de Genetique","author":"Mecke, S.; Passarge, E.","year":"1971","unstructured":"Mecke, S., and Passarge, E. (1971). Encephalocoele, polycystic kidneys and polydactyly as an autosomal recession trait simulating certain other disorders: the Meckel syndrome. 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Journal ofMedical Genetics, 12, 109-110.","journal-title":"Journal ofMedical Genetics"},{"key":"ref_10","first-page":"267","article-title":"Prenatal diagnosis of the Meckel syndrome: use of serial ultrasound and alpha-fetoprotein measurements","volume":"13","author":"Shapiro, L.J.; Kaback, M.M.; Todmey, K.E.; Sarti, D.; Luther, P.; Cousins, L.","year":"1977","unstructured":"Shapiro, L. J., Kaback, M. M., Todmey, K. E., Sarti, D., Luther, P., and Cousins, L. (1977). Prenatal diagnosis of the Meckel syndrome: use of serial ultrasound and alpha-fetoprotein measurements. Birth Defects: Original Article Series, 13, 267-272. The National Foundation-March of Dimes, New York.","journal-title":"Birth Defects: Original Article Series"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1056\/NEJM197606242942617","article-title":"Neural tube defects","volume":"294","author":"Welch, J.P.","year":"1976","unstructured":"Welch, J. P. (1976). Neural tube defects. 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