{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T18:48:34Z","timestamp":1772218114139,"version":"3.50.1"},"reference-count":50,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1979,10]]},"abstract":"<jats:p>Published reports on the sex ratio of spina bifida have been reviewed. With one exception, there seems to be no evidence of variation in the sex ratio of spina bifida. In particular, unlike anencephaly, the sex ratio of spina bifida seems to be unrelated to the prevalence of the malformation: this (M\/(M+F)) is of the order of 0.44 in respect of all spina bifida births (liveborn and stillborn). The sex ratio of spina bifida in Negroes does not seem to differ from that in whites (though the data on this point are not numerous). The exception noted above concerns spina bifida occurrring in twins: these cases are disproportionately often female. The point stands in need of explanation.<\/jats:p>","DOI":"10.1136\/jmg.16.5.384","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T14:50:51Z","timestamp":1226328651000},"page":"384-388","source":"Crossref","is-referenced-by-count":17,"title":["The sex ratio in spina bifida."],"prefix":"10.1136","volume":"16","author":[{"given":"W H","family":"James","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1979,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1001\/archneur.1962.04210050047005","article-title":"Anencephalus, hydrocephalus and spina bifida","volume":"7","author":"Alter, M.","year":"1962","unstructured":"Alter, M. (1962). Anencephalus, hydrocephalus and spina bifida. 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So it seems that Negro cases are disproportionately often male","year":"1978","unstructured":"Note added in proof Since this paper was prepared, data on a large sample of liveborn Negro spina bifida cases have been published (Taffel, 1978). When these are pooled with the data cited above, there are 131 male and 109 female Negro spina bifida cases. Tested against a sex ratio of 0 -46 (as suggested for liveborn cases in Table 3 above), these data yield a x2 of 7x12, P<0 -01. So it seems that Negro cases are disproportionately often male."},{"key":"ref_50","article-title":"Congenital Anomalies and Birth Injuries AmongLive Births: UnitedStates, 1973-74. Vital and Health Statistics, Series 21, Number 31","author":"Taffel, S.","year":"1978","unstructured":"Taffel, S. (1978). Congenital Anomalies and Birth Injuries AmongLive Births: UnitedStates, 1973-74. Vital and Health Statistics, Series 21, Number 31. US Department of Health, Education and Welfare, Hyattsville, Maryland."}],"container-title":["Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jmg.16.5.384","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T18:43:23Z","timestamp":1760726603000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmg.bmj.com\/lookup\/doi\/10.1136\/jmg.16.5.384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,10]]},"references-count":50,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1979,10,1]]},"published-print":{"date-parts":[[1979,10]]}},"alternative-id":["10.1136\/jmg.16.5.384"],"URL":"https:\/\/doi.org\/10.1136\/jmg.16.5.384","relation":{},"ISSN":["0022-2593","1468-6244"],"issn-type":[{"value":"0022-2593","type":"print"},{"value":"1468-6244","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,10]]}}}