{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:16:01Z","timestamp":1760832961546,"version":"build-2065373602"},"reference-count":11,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1980,6]]},"abstract":"<jats:p>The parents of 226 of the 360 patients with anencephalus or spinal bifida or both, born in Belfast 1964 to 1968, were visited to document the occurrence of these malformations among other relatives. The proportions of sibs with anencephalus and spina bifida were 10.41% for spina bifida index patients and 6.4% for anencephalus. For patients born after the index patients, the proportions were 12.19% and 6.35%, respectively. The overall incidence of either malformation among sibs was 8.87%. This estimate is higher than the 4 to 5% commonly reported and is probably related to the specific background of the Northern Ireland population, which is known to have the highest incidence of CNS malformations in the United Kingdom. The substantial size of this risk indicates the importance of amniocentesis for monitoring subsequent pregnancies of women who have had one child with a CNS malformation.<\/jats:p>","DOI":"10.1136\/jmg.17.3.203","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T14:52:06Z","timestamp":1226328726000},"page":"203-211","source":"Crossref","is-referenced-by-count":11,"title":["A family study of spina bifida and anencephalus in Belfast, Northern Ireland (1964 to 1968)."],"prefix":"10.1136","volume":"17","author":[{"given":"N C","family":"Nevin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W P","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1980,6,1]]},"reference":[{"key":"ref_1","first-page":"73","article-title":"Factors associated with anencephalus and spina bifida in Belfast","volume":"27","author":"Elwood, J.H.; Nevin, N.C.","year":"1973","unstructured":"Elwood JH, Nevin NC. Factors associated with anencephalus and spina bifida in Belfast. Br J Prev Soc Med 1973;27:73-80.","journal-title":"Br J Prev Soc Med"},{"key":"ref_2","first-page":"213","article-title":"Anencephalus and spina bifida in Belfast (1964-1968)","volume":"42","author":"Elwood, J.H.; Nevin, N.C.","year":"1973","unstructured":"Elwood JH, Nevin NC. Anencephalus and spina bifida in Belfast (1964-1968). Ulster MedJ 1973;42:213-22.","journal-title":"Ulster MedJ"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1136\/jmg.5.2.81","article-title":"A family study of major central nervous system malformations in South Wales","volume":"5","author":"Carter, C.O.; David, P.A.; Laurence, K.M.","year":"1968","unstructured":"Carter CO, David PA, Laurence KM. A family study of major central nervous system malformations in South Wales. 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