{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:37:45Z","timestamp":1760747865123,"version":"build-2065373602"},"reference-count":18,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1981,2]]},"abstract":"<jats:p>An observation of suspected interaction of \u03b4\u03b2<jats:sup>0<\/jats:sup>- and \u03b1-thalassaemia, identified through careful examination of the family, is reported. The \u03b4\u03b2<jats:sup>0<\/jats:sup>-thalassaemia was of the usual type found in Sardinia, characterised by high Hb F levels and very low levels of glycine in the isolated \u03b3CB<jats:sub>3<\/jats:sub> peptide. The haematological findings in the double \u03b4\u03b2<jats:sup>0<\/jats:sup>-\/\u03b1-thalassaemia heterozygotes were: normal MCV and Hb A<jats:sub>2<\/jats:sub> levels, increased Hb F (11\u00b73 to 16\u00b78%) heterogeneously distributed in red cells, and almost balanced \u03b1\/\u03b2 globin chain synthesis ratios.<\/jats:p>","DOI":"10.1136\/jmg.18.1.40","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T14:52:06Z","timestamp":1226328726000},"page":"40-42","source":"Crossref","is-referenced-by-count":1,"title":["Interaction of \u03b1- and \u03b4\u03b2<sup>0<\/sup>-thalassaemia: haematological features and globin chain synthesis analysis"],"prefix":"10.1136","volume":"18","author":[{"given":"R","family":"Galanello","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Furbetta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A","family":"Melis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Rosatelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1981,2,1]]},"reference":[{"key":"ref_1","article-title":"The thalassaemia syndromes","author":"Weatherall, D.J.; Clegg, J.B.","year":"1972","unstructured":"Weatherall DJ, Clegg JB. 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