{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:18:52Z","timestamp":1760833132804,"version":"build-2065373602"},"reference-count":10,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1981,2]]},"abstract":"<jats:p>This report describes two patients with a distinctive type of dicentric autosomal chromosome formed by breakage and union between homologous chromosomes. These stable chromosomes possess two C bands, implying the presence of two centromeric regions. The first child, evaluated for dysmorphic features was shown to have an abnormal chromosome 16, designated as 46, XX, -16, + dic (16) (pter leads to cen leads to q22::p11 leads to qter). The second case is a child with the typical features of trisomy 18 whose karyotype is designated as 46, XX, -18, + dic (18) (qter leads to p11.1 :: p11.3 leads to cen leads to qter). The stability of these chromosomes is presumably in result of centromere suppression and associated premature centromere division of the suppressed centromere. The possible mechanism of formation of these homodicentric chromosomes is presented, and a comparison is made between them and three patients with dicentric X chromosomes.<\/jats:p>","DOI":"10.1136\/jmg.18.1.54","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T14:52:06Z","timestamp":1226328726000},"page":"54-58","source":"Crossref","is-referenced-by-count":22,"title":["Homodicentric chromosomes: a distinctive type of dicentric chromosome."],"prefix":"10.1136","volume":"18","author":[{"given":"B E","family":"Ward","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C M","family":"Bradley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J B","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1981,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1136\/jmg.13.5.381","article-title":"Structure and inheritance of some heterozygous Robertsonian translocations in man","volume":"13","author":"Daniel, A.; Lam-Po-Tang, P.R.L.C.","year":"1976","unstructured":"Daniel A, Lam-Po-Tang PRLC. Structure and inheritance of some heterozygous Robertsonian translocations in man. J Med Genet 1976;13:381-8.","journal-title":"J Med Genet"},{"key":"ref_2","first-page":"90","article-title":"Quantitative colonial growth of isolated mammalian cells","volume-title":"Methods in enzymology. vol V","author":"Ham, R.G.; Puck, T.T.","year":"1962","unstructured":"Ham RG, Puck TT. Quantitative colonial growth of isolated mammalian cells. In: Colowick SP, Kaplan NO, eds. Methods in enzymology. vol V. NewYork: Academic Press, 1962:90-119."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S0140-6736(71)90287-X","article-title":"A rapid banding technique for human chromosomes","volume":"ii:","author":"Seabright, M.","year":"1971","unstructured":"Seabright M. A rapid banding technique for human chromosomes. Lancet 1971;ii:971-2.","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000130130","article-title":"Localization of heterochromatin in human chromosomes","volume":"10","author":"Arrighi, F.E.; Hsu, T.C.","year":"1971","unstructured":"Arrighi FE, Hsu TC. Localization of heterochromatin in human chromosomes. Cytogenetics 1971;10:81-6.","journal-title":"Cytogenetics"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/0014-4827(70)90586-0","article-title":"Analysis of the human metaphase chromosome set by aid of DNAbinding fluorescent agents","volume":"62","author":"Caspersson, T.; Zech, L.; Johansson, C.","year":"1970","unstructured":"Caspersson T, Zech L, Johansson C. Analysis of the human metaphase chromosome set by aid of DNAbinding fluorescent agents. Exp Cell Res 1970;62:490-2.","journal-title":"Exp Cell Res"},{"issue":"39","key":"ref_6","first-page":"243","article-title":"18p syndrome resulting from 14q\/18q 'dicentric' fusion translocation","volume":"1977","author":"Funderburk, S.J.; Sparkes, R.S.; Klisak, I.","unstructured":"Funderburk SJ, Sparkes RS, Klisak I. 18p syndrome resulting from 14q\/18q 'dicentric' fusion translocation. Hum Genet 1977:39:243-50.","journal-title":"Hum Genet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/j.1399-0004.1977.tb01325.x","article-title":"A complex mosaic with D\/E translocation tdic(15; 18)(pl2; pll) in an oligospermic male with apparently total infertility","volume":"11","author":"Singh-Kahlan, D.P.; Serra, A.; Bora, R.","year":"1977","unstructured":"Singh-Kahlan DP, Serra A, Bora R. A complex mosaic with D\/E translocation tdic(15;18)(pl2;pll) in an oligospermic male with apparently total infertility. Clin Genet 1977;11:342-8.","journal-title":"Clin Genet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF00273279","article-title":"Single Cd band in dicentric translocations with one suppressed centromere","volume":"48","author":"Daniel, A.","year":"1979","unstructured":"Daniel A. Single Cd band in dicentric translocations with one suppressed centromere. Hum Genet 1979;48:85-92.","journal-title":"Hum Genet"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1136\/jmg.12.4.378","article-title":"Differences in human X isochromosomes","volume":"12","author":"Priest, J.H.; Blackston, R.D.; Au, K.S.; Ray, S.L.","year":"1975","unstructured":"Priest JH, Blackston RD, Au KS, Ray SL. Differences in human X isochromosomes. J Med Genet 1975;12: 378-89.","journal-title":"J Med Genet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1399-0004.1978.tb02120.x","article-title":"Partial tetrasomy 9 in a liveborn infant","volume":"14","author":"Wisniewski, L.; Politis, G.D.; Higgins, J.V.","year":"1978","unstructured":"Wisniewski L, Politis GD, Higgins JV. Partial tetrasomy 9 in a liveborn infant. Clin Genet 1978;14:147-53.","journal-title":"Clin Genet"}],"container-title":["Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jmg.18.1.54","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:50:05Z","timestamp":1760773805000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmg.bmj.com\/lookup\/doi\/10.1136\/jmg.18.1.54"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,2]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1981,2,1]]},"published-print":{"date-parts":[[1981,2]]}},"alternative-id":["10.1136\/jmg.18.1.54"],"URL":"https:\/\/doi.org\/10.1136\/jmg.18.1.54","relation":{},"ISSN":["0022-2593","1468-6244"],"issn-type":[{"type":"print","value":"0022-2593"},{"type":"electronic","value":"1468-6244"}],"subject":[],"published":{"date-parts":[[1981,2]]}}}