{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T21:42:13Z","timestamp":1766266933763,"version":"build-2065373602"},"reference-count":8,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1981,4]]},"abstract":"<jats:p>The first degree relatives of 174 children with congenital isolated structural talipes equinovarus were examined by an orthopaedic surgeon. The affected rate of first degree relatives was 27 times higher than the birth prevalence of Hungarian newborns. The heritability in the parents and sibs was 0.82 +\/- 0.15. The multifactorial threshold model was proved by the so-called GAMT programme on the basis of the identity of the h2 values in the different generations of first degree relatives. A relatively lower familial clustering was found in gypsies who had a higher prevalence.<\/jats:p>","DOI":"10.1136\/jmg.18.2.99","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T14:52:06Z","timestamp":1226328726000},"page":"99-100","source":"Crossref","is-referenced-by-count":10,"title":["Confirmation of the multifactorial threshold model for congenital structural talipes equinovarus."],"prefix":"10.1136","volume":"18","author":[{"given":"A","family":"Czeizel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Bellyei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Kr\u00e1nicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Mocsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Tusn\u00e1dy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1981,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/00003086-197205000-00003","article-title":"Genetic and environmental factors in the etiology of talipes equinovarus","volume":"84","author":"Wynne-Davies, R.","year":"1972","unstructured":"Wynne-Davies R. Genetic and environmental factors in the etiology of talipes equinovarus. Clin Orthop 1972;84: 9-13.","journal-title":"Clin Orthop"},{"key":"ref_2","first-page":"1280","article-title":"Birth prevalence of the congenital structural talipes equinovarus in Hungary","volume":"118","author":"Bellyei, A.; Czeizel, A.; Kranicz, J.","year":"1977","unstructured":"Bellyei A, Czeizel A, Kranicz J. Birth prevalence of the congenital structural talipes equinovarus in Hungary. Orv Hetil 1977;118:1280-2.","journal-title":"Orv Hetil"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1136\/jmg.2.4.227","article-title":"Family studies and aetiology of club foot","volume":"2","author":"Wynne-Davies, R.","year":"1965","unstructured":"Wynne-Davies R. Family studies and aetiology of club foot. J Med Genzet 1965;2:227-32.","journal-title":"J Med Genzet"},{"key":"ref_4","first-page":"21","article-title":"Genetics of common single malformations","volume":"32","author":"Carter, C.O.","year":"1976","unstructured":"Carter CO. Genetics of common single malformations. Br Med Bull 1976;32:21-6."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/ajmg.1320040307","article-title":"A family study of congenital inguinal hernia","volume":"4","author":"Czeizel, A.; Gardonyi, J.","year":"1979","unstructured":"Czeizel A, Gardonyi J. A family study of congenital inguinal hernia. Am J Med Genet 1979;4:247-54.","journal-title":"Am J Med Genet"},{"key":"ref_6","first-page":"149","article-title":"The baseline data of the Hungarian Congenital Malformation Register, 1970-1976","volume":"19","author":"Czeizel, A.","year":"1978","unstructured":"Czeizel A. The baseline data of the Hungarian Congenital Malformation Register, 1970-1976. Acta Paediatr Acad Sci Hung 1978;19:149-56.","journal-title":"Acta Paediatr Acad Sci Hung"},{"key":"ref_7","first-page":"566","article-title":"Genetic and epidemiological studies of clubfoot sn Hawasi: ascertainment and incidence","volume":"21","author":"Ching, G.H.S.; Chung, C.S.; Nemechek, R.W.","year":"1969","unstructured":"Ching GHS, Chung CS, Nemechek RW. Genetic and epidemiological studies of clubfoot sn Hawasi: ascertainment and incidence. Am J Hum Genet 1969;21:566-80.","journal-title":"Am J Hum Genet"},{"key":"ref_8","first-page":"44","article-title":"Racial and prenatal factors in major congenital malformations","volume":"20","author":"Chung, C.S.; Myrianthopoulos, N.C.; Yoshizaki, H.","year":"1968","unstructured":"Chung CS, Myrianthopoulos NC, Yoshizaki H. Racial and prenatal factors in major congenital malformations. Am J Hum Genet 1968;20:44-60.","journal-title":"Am J Hum Genet"}],"container-title":["Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jmg.18.2.99","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T04:03:47Z","timestamp":1759723427000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmg.bmj.com\/lookup\/doi\/10.1136\/jmg.18.2.99"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,4]]},"references-count":8,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1981,4,1]]},"published-print":{"date-parts":[[1981,4]]}},"alternative-id":["10.1136\/jmg.18.2.99"],"URL":"https:\/\/doi.org\/10.1136\/jmg.18.2.99","relation":{},"ISSN":["0022-2593","1468-6244"],"issn-type":[{"type":"print","value":"0022-2593"},{"type":"electronic","value":"1468-6244"}],"subject":[],"published":{"date-parts":[[1981,4]]}}}