{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:18:30Z","timestamp":1783477110367,"version":"3.55.0"},"reference-count":28,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1982,2]]},"abstract":"<jats:p>Testicular biopsies from eight men with abnormal karyotypes have been examined for histological and cytogenetic evidence of disturbances of meiosis. Quantitative analysis of this material showed one, with a 13;14 Robertsonian translocation, to have apparently normal spermatogenesis. Three patients, one with a 47,XYY and two with 45,XY, inv 9 karyotypes, had an overall depression of spermatogenesis. Four others, all with major chromosomal abnormalities, had apparently normal spermatogenesis until the primary spermatocyte stage. Two of these had sex autosomal translocations. One, 45,Y,t(X;21), had a complete block at MI, the other, 46,X,t(Y;16), had a partial block at spermatid formation. One man with a reciprocal 2;10 translocation showed delay at all stages beyond spermatocyte formation and one man with an inversion of chromosome 3 showed impaired spermatid maturation.<\/jats:p>","DOI":"10.1136\/jmg.19.1.49","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T14:52:06Z","timestamp":1226328726000},"page":"49-56","source":"Crossref","is-referenced-by-count":29,"title":["Cytogenetic and histological studies of testicular biopsies from subfertile men with chromosome anomaly."],"prefix":"10.1136","volume":"19","author":[{"given":"M J","family":"Faed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M A","family":"Lamont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Baxby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1982,2,1]]},"reference":[{"key":"ref_1","first-page":"58","article-title":"l2tude des chromosomes mitotiques et m6iotiques chez les hommes infertiles","volume":"23","author":"Koulischer, L.; Schoysman, R.","year":"1975","unstructured":"Koulischer L, Schoysman R. l2tude des chromosomes mitotiques et m6iotiques chez les hommes infertiles. J Genet Hum (Suppl) 1975;23:58-70.","journal-title":"J Genet Hum (Suppl)"},{"issue":"231-54","key":"ref_2","first-page":"3","article-title":"Karyotype and seminal analysis","volume":"39","author":"Faed, M.J.W.; Robertson, J.; Lamont, M.A.","year":"1975","unstructured":"Karyotype and seminal analysis. Ann Hum Genet 1975;39:231-54. 3 Faed MJW, Robertson J, Lamont MA, et al. A cytogenetic survey of men being investigated for subfertility. J Reprod Fertil 1979;56:209-16.","journal-title":"J Reprod Fertil; A cytogenetic survey of men being investigated for subfertility"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1159\/000130218","article-title":"Translocation heterozygosity and associated subfertility in man","volume":"11","author":"Chandley, A.C.; Christie, S.; Fletcher, J.; Frackiewicz, A.; Jacobs, P.A.","year":"1972","unstructured":"Chandley AC, Christie S, Fletcher J, Frackiewicz A, Jacobs PA. 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A case of chromosome 3 duplication q deletion p syndrome born to the mother with a pericentric inversion, inv (3) (p25 q21) Jpn J Huim Genet 1979;24:9-12.","journal-title":"J Huim Genet"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1159\/000130206","article-title":"Inherited pericentric inversion of chromosome 5. A family with history of neonatal death and a case of the 'cri du chat' syndrome","volume":"11","author":"Faed, M.J.W.; Marrian, V.J.; Robertson, J.; Robson, E.B.; Cook, P.J.L.","year":"1972","unstructured":"Faed MJW, Marrian VJ, Robertson J, Robson EB, Cook, PJL. Inherited pericentric inversion of chromosome 5. A family with history of neonatal death and a case of the 'cri du chat' syndrome. 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