{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:52:31Z","timestamp":1783039951519,"version":"3.54.6"},"reference-count":5,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1982,6]]},"abstract":"<jats:p>The Leser-Trelat sign is the sudden appearance and rapid increase in size and number of seborrhoeic keratoses in association with cancer. Twenty cases of this unusual phenomenon have so far been reported in the world literature. More than half involve adenocarcinomas and none was shown to be familial. We report a unique example of a 41-year-old black female and her 74-year-old black mother, both of whom have demonstrated classical clinical-pathological evidence of the Leser-Trelat sign and adenocarcinoma of the breast. The remainder of the family history was negative for cutaneous lesions and cancer. The aetiological and pathogenetic significance of the Leser-Trelat sign in association with carcinoma of the breast in this mother and daughter remains obscure.<\/jats:p>","DOI":"10.1136\/jmg.19.3.218","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T14:52:06Z","timestamp":1226328726000},"page":"218-221","source":"Crossref","is-referenced-by-count":14,"title":["Leser-Trelat sign in mother and daughter with breast cancer."],"prefix":"10.1136","volume":"19","author":[{"given":"H T","family":"Lynch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R M","family":"Fusaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J A","family":"Pester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J F","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1982,6,1]]},"reference":[{"key":"ref_1","first-page":"2434","article-title":"Adenocarcinoma of the stomach with eruptive seborrheic keratoses: the sign of","volume":"45","author":"Sperry, K.; Wall, J.","year":"1980","unstructured":"Sperry K, Wall J. Adenocarcinoma of the stomach with eruptive seborrheic keratoses: the sign of Leser-Trelat. Cancer 1980;45:2434-7.","journal-title":"Leser-Trelat. Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1001\/archderm.1973.01620260048019","volume":"108","author":"Dantzig, P.I.","year":"1973","unstructured":"Dantzig PI. Sign of Leser-Trelat. Arch Dermatol 1973; 108:700-1.","journal-title":"Sign of Leser-Trelat. Arch Dermatol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1002\/1097-0142(19801001)46:7<1657::AID-CNCR2820460727>3.0.CO;2-A","article-title":"Bile duct adenocarcinoma with Leser-Trelat sign and pure red blood cell aplasia","volume":"46","author":"Lee, C.H.; Clark, A.R.; Thorpe, M.E.; Mackie, B.S.; Firkin, F.C.","year":"1980","unstructured":"Lee CH, Clark AR, Thorpe ME, Mackie BS, Firkin FC. Bile duct adenocarcinoma with Leser-Trelat sign and pure red blood cell aplasia. Cancer 1980;46:1657-60.","journal-title":"Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1001\/jama.1979.03300120022017","article-title":"Family history in an oncology clinic: implications for cancer genetics","volume":"242","author":"Lynch, H.T.; Follett, K.L.; Lynch, P.M.; Albano, W.A.; Mailliard, J.A.; Pierson, R.L.","year":"1979","unstructured":"Lynch HT, Follett KL, Lynch PM, Albano WA, Mailliard JA, Pierson RL. Family history in an oncology clinic: implications for cancer genetics. JAMA 1979;242: 1268-72.","journal-title":"JAMA"},{"key":"ref_5","article-title":"Cancer-associated genodermatoses","author":"Lynch, H.T.; Fusaro, R.M.","unstructured":"Lynch HT, Fusaro RM. Cancer-associated genodermatoses. New York: Van Nostrand Reinhold (in press)."}],"container-title":["Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jmg.19.3.218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T17:58:56Z","timestamp":1759687136000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmg.bmj.com\/lookup\/doi\/10.1136\/jmg.19.3.218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,6]]},"references-count":5,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1982,6,1]]},"published-print":{"date-parts":[[1982,6]]}},"alternative-id":["10.1136\/jmg.19.3.218"],"URL":"https:\/\/doi.org\/10.1136\/jmg.19.3.218","relation":{},"ISSN":["0022-2593","1468-6244"],"issn-type":[{"value":"0022-2593","type":"print"},{"value":"1468-6244","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,6]]}}}