{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:02:18Z","timestamp":1791259338250,"version":"4.1.0"},"reference-count":10,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1982,12]]},"abstract":"<jats:p>Comparison of the disease course in patients with the severe and mild forms of Hunter's syndrome indicates that the severely affected boys show a higher incidence of behavioural disorder, diarrhoea, convulsions, and terminal cachexia. It is proposed that all of these differences may be attributed to the underlying neurodegeneration which characterises the severe form of the disease. A means of predicting the ultimate disease outcome in a young isolated case is presented.<\/jats:p>","DOI":"10.1136\/jmg.19.6.408","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T14:52:06Z","timestamp":1226328726000},"page":"408-411","source":"Crossref","is-referenced-by-count":101,"title":["A clinical and genetic study of Hunter's syndrome. 2 Differences between the mild and severe forms"],"prefix":"10.1136","volume":"19","author":[{"given":"I D","family":"Young","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P S","family":"Harper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R G","family":"Newcombe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I M","family":"Archer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1982,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1365-2214.1981.tb00838.x","article-title":"Psychosocial problems in Hunter's syndrome","volume":"7","author":"Young, I.D.; Harper, P.S.","year":"1981","unstructured":"Young ID, Harper PS. Psychosocial problems in Hunter's syndrome. Child Care Health Dev 1981;7:201-9.","journal-title":"Child Care Health Dev"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1399-0004.1979.tb00861.x","article-title":"Long term complications in Hunter's syndrome","volume":"16","author":"Young, I.D.; Harper, P.S.","year":"1979","unstructured":"Young ID, Harper PS. Long term complications in Hunter's syndrome. Clin Genet 1979;16:125-32.","journal-title":"Clin Genet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1001\/archpedi.1966.02090150062003","article-title":"Clinical definition of the HurlerHunter phenotypes. A review of 50 patients","volume":"112","author":"Leroy, J.G.; Crocker, A.C.","year":"1966","unstructured":"Leroy JG, Crocker AC. Clinical definition of the HurlerHunter phenotypes. A review of 50 patients. Am J Dis Child 1966;112:518-30.","journal-title":"Am J Dis Child"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/S0016-5085(70)80160-3","article-title":"Ultrastructure of the rectal wall in Hunter's syndrome","volume":"58","author":"Elsner, B.","year":"1970","unstructured":"Elsner B. Ultrastructure of the rectal wall in Hunter's syndrome. Gastroenterology 1970;58:856-62.","journal-title":"Gastroenterology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3171\/jns.1975.43.1.0102","article-title":"Carpal tunnel syndrome in pediatric mucopolysaccharidoses. Report of 4 cases","volume":"43","author":"Miner, M.E.; Schimke, R.N.","year":"1975","unstructured":"Miner ME, Schimke RN. Carpal tunnel syndrome in pediatric mucopolysaccharidoses. Report of 4 cases. J Neurosurg 1975;43:102-3.","journal-title":"J Neurosurg"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1001\/archneur.1976.00500120049008","article-title":"Peripheral nerve involvement in Hunter syndrome (mucopolysaccharidosis II)","volume":"33","author":"Swift, T.R.; McDonald, T.F.","year":"1976","unstructured":"Swift TR, McDonald TF. Peripheral nerve involvement in Hunter syndrome (mucopolysaccharidosis II). Arch Neurol 1976;33:845-6.","journal-title":"Arch Neurol"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1001\/archneur.1974.00490420084010","article-title":"Multiple peripheral nerve entrapments. An unusual phenotypical variant of the Hunter syndrome (mucopolysaccharidosis II) in a family","volume":"31","author":"Karpati, G.; Carpenter, S.; Eisen, A.A.; Wolfe, L.S.; Feindel, W.","year":"1974","unstructured":"Karpati G, Carpenter S, Eisen AA, Wolfe LS, Feindel W. Multiple peripheral nerve entrapments. An unusual phenotypical variant of the Hunter syndrome (mucopolysaccharidosis II) in a family. Arch Neurol 1974;31:418-22.","journal-title":"Arch Neurol"},{"key":"ref_8","article-title":"The mucopolysaccharidoses. In: Heritable disorders of connective tissue","author":"McKusick, V.A.","year":"1972","unstructured":"McKusick VA. The mucopolysaccharidoses. In: Heritable disorders of connective tissue. 4th ed. St Louis: Mosby, 1972.","edition":"4th ed"},{"key":"ref_9","first-page":"425","article-title":"Clinical and probable genetic heterogeneity within mucopolysaccharidosis II. Report of a family with a mild form","volume":"131","author":"Lichtenstein, JR, Bilbrey; GL, McKusick; V.A.","year":"1972","unstructured":"Lichtenstein JR, Bilbrey GL, McKusick VA. Clinical and probable genetic heterogeneity within mucopolysaccharidosis II. Report of a family with a mild form. Johns Hopkins MedJ 1972;131:425-35.","journal-title":"Johns Hopkins MedJ"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/ana.410070418","article-title":"Myelopathy in mucopolysaccharidosis type II (Hunter syndrome)","volume":"7","author":"Ballenger, C.E.; Swift, T.R.; Leshner, R.T.; El Gammal, T.A.; McDonald, T.F.","year":"1980","unstructured":"Ballenger CE, Swift TR, Leshner RT, El Gammal TA, McDonald TF. Myelopathy in mucopolysaccharidosis type II (Hunter syndrome). Ann Neurol 1980;7:382-5.","journal-title":"Ann Neurol"}],"container-title":["Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jmg.19.6.408","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T17:53:31Z","timestamp":1759686811000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmg.bmj.com\/lookup\/doi\/10.1136\/jmg.19.6.408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,12]]},"references-count":10,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1982,12,1]]},"published-print":{"date-parts":[[1982,12]]}},"alternative-id":["10.1136\/jmg.19.6.408"],"URL":"https:\/\/doi.org\/10.1136\/jmg.19.6.408","relation":{},"ISSN":["0022-2593","1468-6244"],"issn-type":[{"value":"0022-2593","type":"print"},{"value":"1468-6244","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,12]]}}}