{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:45:54Z","timestamp":1791071154973,"version":"4.1.0"},"reference-count":22,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1982,12]]},"abstract":"<jats:p>A child with developmental and language delay was found to be homozygous for a pericentric inversion of chromosome 4 (inv(4) (p15 X 2q12)). Her normal mother and aunt are inversion heterozygotes. It is suggested that the phenotypic abnormalities may have resulted from damage at chromosomal breakpoints or from a position effect which is expressed only in homozygous form.<\/jats:p>","DOI":"10.1136\/jmg.19.6.469","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T14:52:06Z","timestamp":1226328726000},"page":"469-471","source":"Crossref","is-referenced-by-count":20,"title":["A homozygote for pericentric inversion of chromosome 4."],"prefix":"10.1136","volume":"19","author":[{"given":"N J","family":"Carpenter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Say","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N D","family":"Barber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1982,12,1]]},"reference":[{"key":"ref_1","first-page":"81","article-title":"Structural rearrangements of the chromosomes in man","author":"Jacobs, P.A.","year":"1977","unstructured":"Jacobs PA. Structural rearrangements of the chromosomes in man. In: Hook EB, Porter IH, eds. Population cytogenetics. New York: Academic Press, 1977:81-97."},{"key":"ref_2","first-page":"746","article-title":"Pericentric inversions of human chromosomes 9 and 10","volume":"26","author":"de la Chapelle A; J, Schroder; K, Stenstrand","year":"1974","unstructured":"de la Chapelle A, Schroder J, Stenstrand K, et al. Pericentric inversions of human chromosomes 9 and 10. Am J Hum Genet 1974;26:746-66.","journal-title":"Am J Hum Genet"},{"key":"ref_3","first-page":"81","article-title":"Structural variation in chromosome 9","volume":"17","author":"Madan, K.; Bobrow, M.","year":"1974","unstructured":"Madan K, Bobrow M. Structural variation in chromosome 9. 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