{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T22:10:03Z","timestamp":1760739003382,"version":"build-2065373602"},"reference-count":11,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1983,10]]},"abstract":"<jats:p>We report two families selected from 124 genotyped Caucasian insulin-dependent diabetes mellitus (IDDM) families because of unusual features. In both families, all offspring are affected and four out of six bear the allele HLA-DR2 which is an uncommon phenotype among diabetic patients. Onset before the age of 1 year in all the patients of one family, association with optic atrophy in the other, and the existence of pairs of affected sibs of different HLA types in both, are infrequent findings and support the evidence of heterogeneity in IDDM.<\/jats:p>","DOI":"10.1136\/jmg.20.5.365","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T14:52:06Z","timestamp":1226328726000},"page":"365-366","source":"Crossref","is-referenced-by-count":1,"title":["HLA-DR2 in two sibships with insulin-dependent diabetes mellitus."],"prefix":"10.1136","volume":"20","author":[{"given":"I","family":"Deschamps","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Lestradet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Schmid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Hors","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1983,10,1]]},"reference":[{"key":"ref_1","article-title":"Insulin-dependent diabetes mellitus. Joint report of the 8th International Histocompatibility Workshop","author":"Svejgaard, A.; Platz, P.; Ryder, L.P.","year":"1980","unstructured":"Svejgaard A, Platz P, Ryder LP. Insulin-dependent diabetes mellitus. Joint report of the 8th International Histocompatibility Workshop. In: Terasaki P, ed. Histocompatibility testing. Los Angeles: UCLA Tissue Typing Laboratory, 1980."},{"key":"ref_2","first-page":"108","article-title":"HLA-D and DR antigens in genetic analysis of insulin-dependent diabetes mellitus","volume":"21","author":"Platz, P.; Jakobsen, D.K.; Morling, N.","year":"1981","unstructured":"Platz P, Jakobsen DK, Morling N, et al. HLA-D and DR antigens in genetic analysis of insulin-dependent diabetes mellitus. Diabetologia 1981;21:108-15.","journal-title":"Diabetologia"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1399-0039.1978.tb01239.x","article-title":"HLA-Dw2 as a marker of resistance against juvenile diabetes mellitus","volume":"11","author":"Ilonen, J.; Herva, E.; Tiilikainen, A.","year":"1978","unstructured":"Ilonen J, Herva E, Tiilikainen A, et al. HLA-Dw2 as a marker of resistance against juvenile diabetes mellitus. Tissue Antigens 1978;11:144-6.","journal-title":"Tissue Antigens"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/oxfordjournals.bmb.a071513","article-title":"HLA genetic heterogeneity in diabetes mellitus","volume":"34","author":"Cudworth, A.G.; Festenstein, H.","year":"1978","unstructured":"Cudworth AG, Festenstein H. HLA genetic heterogeneity in diabetes mellitus. Med Bull 1978;34:285-9.","journal-title":"Med Bull"},{"key":"ref_5","first-page":"43","article-title":"The importance of HLA genes to susceptibility in the development of juvenile diabetes mellitus","volume":"3","author":"Ludwig, H.; Schernthaner, G.; Mayr, W.R.","year":"1977","unstructured":"Ludwig H, Schernthaner G, Mayr WR. The importance of HLA genes to susceptibility in the development of juvenile diabetes mellitus. Diabete Metab 1977;3:43-8.","journal-title":"Diabete Metab"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/BF00275267","article-title":"HLA genotype studies in juvenile insulin-dependent diabetes","volume":"19","author":"Deschamps, I.; Lestradet, H.; Bonaiti, C.","year":"1980","unstructured":"Deschamps I, Lestradet H, Bonaiti C, et al. HLA genotype studies in juvenile insulin-dependent diabetes. Diabetologia 1980;19:189-93.","journal-title":"Diabetologia"},{"key":"ref_7","first-page":"1","article-title":"Juvenile diabetes mellitus, optic atrophy, hearing loss, diabetes insipidus, atonia of the urinary tract and bladder and other abnormalities (Wolfram syndrome)","volume":"264","author":"Cremers, C.W.R.J.; Wijdeveld, P.G.A.B.; Pinckers, A.J.L.G.","year":"1977","unstructured":"Cremers CWRJ, Wijdeveld PGAB, Pinckers AJLG. Juvenile diabetes mellitus, optic atrophy, hearing loss, diabetes insipidus, atonia of the urinary tract and bladder and other abnormalities (Wolfram syndrome). Acta Paediatr Scand (Suppl) 1977;264:1-16.","journal-title":"Acta Paediatr Scand (Suppl)"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1056\/NEJM197912203012515","article-title":"Wolfram syndrome not HLA linked","volume":"301","author":"Stanley, C.A.; Spielman, R.S.; Zmijewski, C.M.; Baker, L.","year":"1979","unstructured":"Stanley CA, Spielman RS, Zmijewski CM, Baker L. Wolfram syndrome not HLA linked. N Engl J Med 1979; 301:1398-9.","journal-title":"N Engl J Med"},{"key":"ref_9","first-page":"776","article-title":"HLA and disease: predictions for HLAhaplotype sharing in families","volume":"33","author":"Weitkamp, L.R.","year":"1981","unstructured":"Weitkamp LR. HLA and disease: predictions for HLAhaplotype sharing in families. Ain J Hum Genet 1981;33: 776-84.","journal-title":"Ain J Hum Genet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1007\/BF00252759","article-title":"Insulin-dependent diabetes mellitus. Is there strong evidence for a non-HLA linked gene?","volume":"20","author":"Suarez, B.K.; Van Eerdewegh, P.","year":"1981","unstructured":"Suarez BK, Van Eerdewegh P. Insulin-dependent diabetes mellitus. Is there strong evidence for a non-HLA linked gene? Diabetologia 1981;20:524-9.","journal-title":"Diabetologia"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1399-0004.1980.tb01365.x","article-title":"Application of the lod-score method to detection of linkage between HLA and juvenile insulindependent diabetes","volume":"18","author":"Clerget-Darpoux, F.; Bonalti-Pellie, C.; Hors, J.; Deschamps, I.; Feingold, N.","year":"1980","unstructured":"Clerget-Darpoux F, Bonalti-Pellie C, Hors J, Deschamps I, Feingold N. Application of the lod-score method to detection of linkage between HLA and juvenile insulindependent diabetes. Clin Genet 1980;18:51-7.","journal-title":"Clin Genet"}],"container-title":["Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jmg.20.5.365","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T21:33:12Z","timestamp":1760736792000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmg.bmj.com\/lookup\/doi\/10.1136\/jmg.20.5.365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,10]]},"references-count":11,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1983,10,1]]},"published-print":{"date-parts":[[1983,10]]}},"alternative-id":["10.1136\/jmg.20.5.365"],"URL":"https:\/\/doi.org\/10.1136\/jmg.20.5.365","relation":{},"ISSN":["0022-2593","1468-6244"],"issn-type":[{"type":"print","value":"0022-2593"},{"type":"electronic","value":"1468-6244"}],"subject":[],"published":{"date-parts":[[1983,10]]}}}