{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:22:11Z","timestamp":1788186131670,"version":"build-2803163510"},"reference-count":25,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    To screen for\n                    <jats:italic>NF2<\/jats:italic>\n                    mutations in people with meningiomas.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Lymphocyte or tumour DNA was analysed from 46 individuals from 36 families who presented with a meningioma at age \u2a7d15 years without vestibular schwannoma (VS), or who had multiple meningiomas in adulthood before the diagnosis of VS.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Eight of 13 people with meningioma and other features of neurofibromatosis 2 (NF2) had an identified constitutional\n                    <jats:italic>NF2<\/jats:italic>\n                    mutation in blood DNA, but none of the other subjects had identified constitutional\n                    <jats:italic>NF2<\/jats:italic>\n                    mutations.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Constitutional\n                    <jats:italic>NF2<\/jats:italic>\n                    mutations are the most likely cause of meningioma in children and in people with a meningioma plus other non-VS features of NF2. Mosaic NF2 may be the cause of about 8% of multiple meningiomas in sporadic adult cases, but there are other causes in the majority of other such patients and in multiple meningioma in families.\n                  <\/jats:p>","DOI":"10.1136\/jmg.2004.023705","type":"journal-article","created":{"date-parts":[[2005,1,5]],"date-time":"2005-01-05T16:50:00Z","timestamp":1104943800000},"page":"45-48","source":"Crossref","is-referenced-by-count":61,"title":["Multiple meningiomas: differential involvement of the\n                    <i>NF2<\/i>\n                    gene in children and adults"],"prefix":"10.1136","volume":"42","author":[{"given":"D G R","family":"Evans","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Watson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A J","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M E","family":"Baser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2005,1,5]]},"reference":[{"key":"2025100511395462000_42.1.45.1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00165649"},{"key":"2025100511395462000_42.1.45.2","doi-asserted-by":"crossref","first-page":"766","DOI":"10.3171\/jns.2000.92.5.0766","volume":"92","year":"2000","journal-title":"J Neurosurg"},{"key":"2025100511395462000_42.1.45.3","first-page":"603","volume":"84","year":"1992","journal-title":"Q J Med"},{"key":"2025100511395462000_42.1.45.4","doi-asserted-by":"crossref","first-page":"847","DOI":"10.3171\/jns.1996.84.5.0847","volume":"84","year":"1996","journal-title":"J Neurosurg"},{"key":"2025100511395462000_42.1.45.5","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1093\/jnen\/59.6.504","volume":"59","year":"2000","journal-title":"J Neuropathol Exp Neurol"},{"key":"2025100511395462000_42.1.45.6","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202531"},{"key":"2025100511395462000_42.1.45.7","first-page":"3226","volume":"58","year":"1998","journal-title":"Cancer Res"},{"key":"2025100511395462000_42.1.45.8","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.10.1495"},{"key":"2025100511395462000_42.1.45.9","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10840"},{"key":"2025100511395462000_42.1.45.10","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1093\/jnen\/59.10.872","volume":"59","year":"2000","journal-title":"J Neuropathol Exp Neurol"},{"key":"2025100511395462000_42.1.45.11","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1136\/adc.81.6.496","volume":"81","year":"1999","journal-title":"Arch Dis Child"},{"key":"2025100511395462000_42.1.45.12","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1093\/jnen\/60.10.994","volume":"60","year":"2001","journal-title":"J Neuropathol Exp Neurol"},{"key":"2025100511395462000_42.1.45.13","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1089\/gte.1999.3.173","volume":"3","year":"1999","journal-title":"Genetic Testing"},{"key":"2025100511395462000_42.1.45.14","doi-asserted-by":"publisher","DOI":"10.1159\/000023538"},{"key":"2025100511395462000_42.1.45.15","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.29.12.841"},{"key":"2025100511395462000_42.1.45.16","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.40.6.459"},{"key":"2025100511395462000_42.1.45.17","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199908000-00049"},{"key":"2025100511395462000_42.1.45.18","doi-asserted-by":"publisher","DOI":"10.1086\/302004"},{"key":"2025100511395462000_42.1.45.19","doi-asserted-by":"crossref","first-page":"562","DOI":"10.3171\/jns.1998.88.3.0562","volume":"88","year":"1998","journal-title":"J Neurosurg"},{"key":"2025100511395462000_42.1.45.20","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1053\/hupa.2002.32229","volume":"33","year":"2002","journal-title":"Hum Pathol"},{"key":"2025100511395462000_42.1.45.21","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1212\/WNL.43.10.2096","volume":"43","year":"1993","journal-title":"Neurology"},{"key":"2025100511395462000_42.1.45.22","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.3171\/jns.2002.97.5.1078","volume":"97","year":"2002","journal-title":"J Neurosurg"},{"key":"2025100511395462000_42.1.45.23","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3171\/jns.2001.94.1.0111","volume":"94","year":"2001","journal-title":"J Neurosurg"},{"key":"2025100511395462000_42.1.45.24","doi-asserted-by":"publisher","DOI":"10.1002\/path.909"},{"key":"2025100511395462000_42.1.45.25","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-3-6"}],"container-title":["Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jmg.2004.023705","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T18:40:04Z","timestamp":1759689604000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmg.bmj.com\/lookup\/doi\/10.1136\/jmg.2004.023705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2005,1,5]]},"published-print":{"date-parts":[[2005,1]]}},"alternative-id":["10.1136\/jmg.2004.023705"],"URL":"https:\/\/doi.org\/10.1136\/jmg.2004.023705","relation":{},"ISSN":["0022-2593","1468-6244"],"issn-type":[{"value":"0022-2593","type":"print"},{"value":"1468-6244","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1]]}}}