{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:27:56Z","timestamp":1783114076815,"version":"3.54.6"},"reference-count":27,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:p>\n                  <jats:bold>Background:<\/jats:bold> APOE is the only gene that has been consistently replicated as a risk factor for late onset Alzheimer\u2019s disease. Several recent studies have identified linkage to chromosome 10 for both risk and age of onset, suggesting that this region harbours genes that influence the development of the disease. A recent study reported association between single nucleotide polymorphisms (SNPs) in the VR22 gene (CTNNA3) on chromosome 10 and plasma levels of A\u03b242, an endophenotype related to Alzheimer\u2019s disease.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Objective:<\/jats:bold> To assess whether polymorphisms in the VR22 gene are associated with Alzheimer\u2019s disease in a large sample of Alzheimer\u2019s disease families and an independent set of unrelated cases and controls.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> Several SNPs showed association in either the family based or case\u2013control analyses (p&lt;0.05). The most consistent findings were with SNP6, for which there was significant evidence of association in both the families and the unrelated cases and controls. Furthermore, there was evidence of significant interaction between APOE-4 and two of the VR22 SNPs, with the strongest evidence of association being concentrated in individuals carrying APOE-4.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusions:<\/jats:bold> This study suggests that VR22 or a nearby gene influences susceptibility to Alzheimer\u2019s disease, and the effect is dependent on APOE status.<\/jats:p>","DOI":"10.1136\/jmg.2004.029553","type":"journal-article","created":{"date-parts":[[2005,9,30]],"date-time":"2005-09-30T15:12:40Z","timestamp":1128093160000},"page":"787-792","source":"Crossref","is-referenced-by-count":29,"title":["Interaction between the \u03b1-T catenin gene (VR22) and APOE in Alzheimer\u2019s disease"],"prefix":"10.1136","volume":"42","author":[{"given":"E R","family":"Martin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P G","family":"Bronson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y-J","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Wall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R-H","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D E","family":"Schmechel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Small","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P-T","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Bartlett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Schnetz-Boutaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J L","family":"Haines","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J R","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M A","family":"Pericak-Vance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2005,9,30]]},"reference":[{"key":"2025100511460443000_42.10.787.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(00)00196-0"},{"key":"2025100511460443000_42.10.787.2","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5500.2304"},{"key":"2025100511460443000_42.10.787.3","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5500.2302"},{"key":"2025100511460443000_42.10.787.4","doi-asserted-by":"publisher","DOI":"10.1086\/339815"},{"key":"2025100511460443000_42.10.787.5","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg357"},{"key":"2025100511460443000_42.10.787.6","doi-asserted-by":"publisher","DOI":"10.1007\/s10048-003-0157-9"},{"key":"2025100511460443000_42.10.787.7","doi-asserted-by":"publisher","DOI":"10.1002\/humu.10282"},{"key":"2025100511460443000_42.10.787.8","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg343"},{"key":"2025100511460443000_42.10.787.9","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.13.7013"},{"key":"2025100511460443000_42.10.787.10","first-page":"136","volume":"21","year":"2000","journal-title":"Neurobiol Aging"},{"key":"2025100511460443000_42.10.787.11","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199909)46:3<412::AID-ANA19>3.0.CO;2-A"},{"key":"2025100511460443000_42.10.787.12","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5500.2303"},{"key":"2025100511460443000_42.10.787.13","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"2025100511460443000_42.10.787.14","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.7.975"},{"key":"2025100511460443000_42.10.787.15","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.8.1467"},{"key":"2025100511460443000_42.10.787.16","unstructured":"Genetic Data Analysis: Computer program for analysis of allelic data 2000."},{"key":"2025100511460443000_42.10.787.17","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/16.2.182"},{"key":"2025100511460443000_42.10.787.18","doi-asserted-by":"publisher","DOI":"10.1086\/302957"},{"key":"2025100511460443000_42.10.787.19","doi-asserted-by":"publisher","DOI":"10.1086\/319525"},{"key":"2025100511460443000_42.10.787.20","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.10258"},{"key":"2025100511460443000_42.10.787.21","doi-asserted-by":"publisher","DOI":"10.1086\/378779"},{"key":"2025100511460443000_42.10.787.22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.11.3443"},{"key":"2025100511460443000_42.10.787.23","unstructured":"Terwilliger JD, Ott J. 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