{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T14:31:58Z","timestamp":1771511518606,"version":"3.50.1"},"reference-count":36,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:p>\n                  <jats:bold>Background:<\/jats:bold> Asperger syndrome is characterised by abnormalities in social interaction as well as repetitive and stereotyped behaviours and interests. The trait is thought to display complex inheritance, but in a subset of families the inheritance resembles the autosomal dominant model. Linkage to 3p14\u201324 has recently been reported in Asperger syndrome in Finnish families with a maximum multipoint NPL<jats:sub>all<\/jats:sub> of 3.32 at D3S2432.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods:<\/jats:bold> We have replicated linkage findings to 3p21\u201324 in 12 new extended Asperger syndrome families. Linkage analyses were performed separately for the 12 new families, and linkage and association analyses were also performed jointly with data from the original genome-wide screen.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> Best two point and multipoint logarithm of the odds (LOD) scores in analyses of both data sets were obtained at D3S2432 (NPL<jats:sub>all<\/jats:sub>\u200a=\u200a3.83) with both subsets of families contributing to linkage. Association analysis of the combined data set produced a trend towards association with D3S2432 and D3S1619.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusions:<\/jats:bold> This study further validates 3q21\u201324 as a candidate region for Asperger syndrome.<\/jats:p>","DOI":"10.1136\/jmg.2005.033621","type":"journal-article","created":{"date-parts":[[2006,2,7]],"date-time":"2006-02-07T16:03:07Z","timestamp":1139328187000},"page":"e06-e06","source":"Crossref","is-referenced-by-count":11,"title":["Independent replication and initial fine mapping of 3p21\u201324 in Asperger syndrome"],"prefix":"10.1136","volume":"43","author":[{"given":"K","family":"Rehnstr\u00f6m","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Ylisaukko-oja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Nieminen-von Wendt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Sarenius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"K\u00e4llman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Kempas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"von Wendt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Peltonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"J\u00e4rvel\u00e4","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2006,2,7]]},"reference":[{"key":"2025101711362769000_43.2.e06.1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/BF01837709","volume":"117","year":"1944","journal-title":"Archiv Psychiatrie Nervenkrankheiten"},{"key":"2025101711362769000_43.2.e06.2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1017\/S0033291700053332","volume":"11","year":"1981","journal-title":"Psychol Med"},{"key":"2025101711362769000_43.2.e06.3","unstructured":"World Health Organization. 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