{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T15:44:50Z","timestamp":1762098290559,"version":"build-2065373602"},"reference-count":15,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:p>\n                  <jats:bold>Background:<\/jats:bold> Lumbar disc disease (LDD) is one of the leading causes of disability in the working-age population. A functional single-nucleotide polymorphism (SNP), +1184T\u2192C, in exon 8 of the cartilage intermediate layer protein gene (<jats:italic>CILP<\/jats:italic>) was recently identified as a risk factor for LDD in the Japanese population (odds ratio (OR) 1.61, 95% CI 1.31 to 1.98), with implications for impaired transforming growth factor\u03b21 signalling.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Aim:<\/jats:bold> To validate this finding in two different ethnic cohorts with LDD.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods:<\/jats:bold> This SNP and flanking SNPs were analysed in 243 Finnish patients with symptoms of LDD and 259 controls, and in 348 Chinese subjects with MRI-defined LDD and 343 controls.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results and conclusion:<\/jats:bold> The results showed no evidence of association in the Finnish (OR\u200a=\u200a1.35, 95% CI 0.97 to 1.87; p\u200a=\u200a0.14) or the Chinese (OR\u200a=\u200a1.05, 95% CI 0.77 to 1.43; p\u200a=\u200a0.71) samples, suggesting that <jats:italic>cartilage intermediate layer protein<\/jats:italic> gene is not a major risk factor for symptoms of LDD in Caucasians or in the general population that included individuals with or without symptoms.<\/jats:p>","DOI":"10.1136\/jmg.2006.047076","type":"journal-article","created":{"date-parts":[[2007,1,12]],"date-time":"2007-01-12T20:34:31Z","timestamp":1168634071000},"page":"285-288","source":"Crossref","is-referenced-by-count":42,"title":["Phenotypic and population differences in the association between <i>CILP<\/i> and lumbar disc disease: \n            Table 1"],"prefix":"10.1136","volume":"44","author":[{"given":"I M","family":"Virtanen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y Q","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K M 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