{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:45:33Z","timestamp":1791276333534,"version":"4.1.0"},"reference-count":10,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p>The gene for insulin-degrading enzyme (<jats:italic>IDE<\/jats:italic>), which is located at chromosome 10q24, has been previously proposed as a candidate gene for late-onset Alzheimer\u2019s disease (AD) based on its ability to degrade amyloid \u03b2-protein. Genotyping of single nucleotide polymorphisms (SNPs) in the <jats:italic>IDE<\/jats:italic> gene in Finnish patients with AD and controls revealed SNPs rs4646953 and rs4646955 to be associated with AD, conferring an approximately two-fold increased risk. Single locus findings were corroborated by the results obtained from haplotype analyses. This suggests that genetic alterations in or near the <jats:italic>IDE<\/jats:italic> gene may increase the risk for developing AD.<\/jats:p>","DOI":"10.1136\/jmg.2006.048470","type":"journal-article","created":{"date-parts":[[2007,5,11]],"date-time":"2007-05-11T21:10:51Z","timestamp":1178917851000},"page":"606-608","source":"Crossref","is-referenced-by-count":36,"title":["Insulin-degrading enzyme is genetically associated with Alzheimer\u2019s disease in the Finnish population"],"prefix":"10.1136","volume":"44","author":[{"given":"Saila","family":"Veps\u00e4l\u00e4inen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Parkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seppo","family":"Helisalmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arto","family":"Mannermaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilkka","family":"Soininen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolph E","family":"Tanzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Bertram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko","family":"Hiltunen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2007,5,11]]},"reference":[{"key":"2025101711472596000_44.9.606.1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.49.32730"},{"key":"2025101711472596000_44.9.606.2","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/S0002-9440(10)63229-4","volume":"164","year":"2004","journal-title":"Am J Pathol"},{"key":"2025101711472596000_44.9.606.3","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5500.2302"},{"key":"2025101711472596000_44.9.606.4","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5500.2303"},{"key":"2025101711472596000_44.9.606.5","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5500.2304"},{"key":"2025101711472596000_44.9.606.6","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","volume":"34","year":"1984","journal-title":"Neurology"},{"key":"2025101711472596000_44.9.606.7","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1212\/WNL.46.2.413","volume":"46","year":"1996","journal-title":"Neurology"},{"key":"2025101711472596000_44.9.606.8","first-page":"S1206","volume":"23","year":"2002","journal-title":"Neurobiology of Aging"},{"key":"2025101711472596000_44.9.606.9","doi-asserted-by":"publisher","DOI":"10.1002\/humu.10282"},{"key":"2025101711472596000_44.9.606.10","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1212\/01.WNL.0000129987.70037.DB","volume":"63","year":"2004","journal-title":"Neurology"}],"container-title":["Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jmg.2006.048470","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T18:47:35Z","timestamp":1760726855000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmg.bmj.com\/lookup\/doi\/10.1136\/jmg.2006.048470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5,11]]},"references-count":10,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2007,8,31]]},"published-print":{"date-parts":[[2007,9]]}},"alternative-id":["10.1136\/jmg.2006.048470"],"URL":"https:\/\/doi.org\/10.1136\/jmg.2006.048470","relation":{},"ISSN":["0022-2593","1468-6244"],"issn-type":[{"value":"0022-2593","type":"print"},{"value":"1468-6244","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5,11]]}}}