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Here, we show that salbutamol, a \u03b22-adrenoceptor agonist, determines a rapid and significant increase in <jats:italic>SMN2<\/jats:italic>-full length mRNA and SMN protein in SMA fibroblasts, predominantly by promoting exon 7 inclusion in <jats:italic>SMN2<\/jats:italic> transcripts. These data, together with previous clinical findings, provide a strong rationale to investigate further the clinical efficacy of salbutamol in SMA patients.<\/jats:p>","DOI":"10.1136\/jmg.2007.051177","type":"journal-article","created":{"date-parts":[[2007,10,12]],"date-time":"2007-10-12T16:03:57Z","timestamp":1192205037000},"page":"29-31","source":"Crossref","is-referenced-by-count":79,"title":["Salbutamol increases SMN mRNA and protein levels in spinal muscular atrophy cells"],"prefix":"10.1136","volume":"45","author":[{"given":"C","family":"Angelozzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Borgo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F 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