{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:34:59Z","timestamp":1792089299843,"version":"4.4.0"},"reference-count":13,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:sec>\n                  <jats:title>Background and aims:<\/jats:title>\n                  <jats:p>Genome-wide association studies in coeliac disease (CD) have resulted in the finding of eight new genetic regions associated with disease susceptibility. However, a replication study performed in the Italian population could not confirm two of those new regions: 2q12 (<jats:italic>IL18RAP<\/jats:italic>) and 3p21 (<jats:italic>CCR3<\/jats:italic>). The aim of this study was to investigate the role of those regions in CD risk in a different Mediterranean population, the Spanish population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>A case\u2013control study with 722 patients with CD and 794 ethnically matched healthy controls was performed. Two single-nucleotide polymorphisms, rs917997 (2q12) and rs6441961 (3p21), were genotyped and their genetic frequencies were compared between both groups using the \u03c7<jats:sup>2<\/jats:sup> test.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>An association was found with rs6441961 (p\u200a=\u200a0.0004, OR\u200a=\u200a1.32, 95% CI 1.13 to 1.54). A non-significant result (but concordant with the initial study) was obtained for rs917997.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>The association of the 3p21 genetic region with CD susceptibility in the Spanish population was confirmed. In 2q12, the initially described OR is most probably overestimated and therefore the real situation may be the existence of a genuine but weak risk factor, which generates statistical power limitations.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jmg.2009.067041","type":"journal-article","created":{"date-parts":[[2009,6,19]],"date-time":"2009-06-19T20:18:14Z","timestamp":1245442694000},"page":"617-619","source":"Crossref","is-referenced-by-count":15,"title":["Association of <i>IL18RAP<\/i> and <i>CCR3<\/i> with coeliac disease in the Spanish population"],"prefix":"10.1136","volume":"46","author":[{"given":"B","family":"Dema","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Fern\u00e1ndez-Arquero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Maluenda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Polanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E G","family":"de la Concha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Urcelay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2009,6,18]]},"reference":[{"key":"2025100510392301000_46.9.617.1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.075119"},{"key":"2025100510392301000_46.9.617.2","doi-asserted-by":"publisher","DOI":"10.1038\/ng2058"},{"key":"2025100510392301000_46.9.617.3","doi-asserted-by":"publisher","DOI":"10.1038\/ng.102"},{"key":"2025100510392301000_46.9.617.4","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2008.061457"},{"key":"2025100510392301000_46.9.617.5","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn438"},{"key":"2025100510392301000_46.9.617.6","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s11882-004-0048-7","article-title":"Chemokines in inflammatory bowel disease.","volume":"4","author":"Papadakis","year":"2004","journal-title":"Curr Allergy Asthma Rep"},{"key":"2025100510392301000_46.9.617.7","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.078048"},{"key":"2025100510392301000_46.9.617.8","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.075028"},{"key":"2025100510392301000_46.9.617.9","doi-asserted-by":"crossref","unstructured":"Lammers KM Lu R Brownley J Lu B Gerard C Thomas K Rallabhandi P Shea-Donohue T Tamiz A Alkan S Netzel-Arnett S Antalis T Vogel SN Fasano A . Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3. Gastroenterology 2008;135:194\u2013204 e3.","DOI":"10.1053\/j.gastro.2008.03.023"},{"key":"2025100510392301000_46.9.617.10","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1365-2249.2007.03457.x","article-title":"Polymorphisms in chemokine receptor genes and susceptibility to Kawasaki disease.","volume":"150","author":"Breunis","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"2025100510392301000_46.9.617.11","doi-asserted-by":"publisher","DOI":"10.1159\/000097502"},{"key":"2025100510392301000_46.9.617.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2008.03.016"},{"key":"2025100510392301000_46.9.617.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.06.030"}],"container-title":["Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jmg.2009.067041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T17:39:28Z","timestamp":1759685968000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmg.bmj.com\/lookup\/doi\/10.1136\/jmg.2009.067041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6,18]]},"references-count":13,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2009,9,1]]},"published-print":{"date-parts":[[2009,9]]}},"alternative-id":["10.1136\/jmg.2009.067041"],"URL":"https:\/\/doi.org\/10.1136\/jmg.2009.067041","relation":{},"ISSN":["0022-2593","1468-6244"],"issn-type":[{"value":"0022-2593","type":"print"},{"value":"1468-6244","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6,18]]}}}