{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T15:24:24Z","timestamp":1774106664538,"version":"3.50.1"},"reference-count":18,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1984,2]]},"abstract":"<jats:p>The incidence of holoprosencephaly with normal chromosomes has been estimated at between 1 in 16 000 and 1 in 53 394 live births. It has been found that during a 3-year period in the Bristol and Weston Health District there were six cases of holoprosencephaly, two of which were familial, and these cases are described. This represents an incidence of 1 in 5200 and during the preceding 3-year period the incidence in the same area was 1 in 14 520 births.<\/jats:p>","DOI":"10.1136\/jmg.21.1.21","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T15:09:16Z","timestamp":1226329756000},"page":"21-26","source":"Crossref","is-referenced-by-count":30,"title":["What is the incidence of holoprosencephaly?"],"prefix":"10.1136","volume":"21","author":[{"given":"E S","family":"Saunders","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Shortland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P M","family":"Dunn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1984,2,1]]},"reference":[{"key":"ref_1","article-title":"Arhinencephalie a\/s Tvpsche Art Von Missbil\/dng","author":"Kundrat, H.","year":"1882","unstructured":"Kundrat H. Arhinencephalie a\/s Tvpsche Art Von Missbil\/dng. Graz: Leuschner and Lubensky, 1882."},{"key":"ref_2","first-page":"895","volume":"62","author":"Landau, J.W.; Barry, J.M.; Arhinencephaly, Koch R.","year":"1963","unstructured":"Landau JW, Barry JM, Koch R. Arhinencephaly. J Peliatr 1963;62:895.","journal-title":"J Peliatr"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/S0022-3476(64)80405-4","volume":"65","author":"Bishop, K.; Connolly, J.M.; Carter, C.H.; Holoprosencephaly, Carpenter D.G.","year":"1964","unstructured":"Bishop K, Connolly JM, Carter CH, Carpenter DG. Holoprosencephaly. J Pedliatr 1964;65:406-14.","journal-title":"J Pedliatr"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1212\/WNL.13.11.913","article-title":"Familial alobar holoprosencephaly (arhinencephaly) with median cleft lip and palate. 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