{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:00:14Z","timestamp":1791115214605,"version":"4.1.0"},"reference-count":12,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1984,8]]},"abstract":"<jats:p>The three English families in this report have a total of 21 members (16 females and five males) suffering from chronic hidradenitis suppurativa. In family A the condition is associated with acne conglobata and there is vertical transmission of the disorder through three generations. In the others there is no associated cystic acne, but all those affected had a history of acne vulgaris with comedone formation, and the condition has been confirmed in two generations. It is likely that a male in an earlier generation in family B suffered from the disease and affected sibs in family C were born to different fathers. The familial aggregation and number of affected subjects suggests a single gene disorder and the pattern of transmission is consistent with autosomal dominant inheritance. Males and females are affected in successive generations and there is the anticipated variation in clinical severity in those suffering from the condition.<\/jats:p>","DOI":"10.1136\/jmg.21.4.281","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T15:09:16Z","timestamp":1226329756000},"page":"281-285","source":"Crossref","is-referenced-by-count":57,"title":["Familial hidradenitis suppurativa: evidence in favour of single gene transmission."],"prefix":"10.1136","volume":"21","author":[{"given":"J S","family":"Fitzsimmons","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E M","family":"Fitzsimmons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1984,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1001\/archderm.1952.01530220044004","article-title":"Hidradenitis and other variants of acne","volume":"65","author":"Brunsting, H.A.","year":"1952","unstructured":"Brunsting HA. Hidradenitis and other variants of acne. Arch Dermatol 1952;65:303-15.","journal-title":"Arch Dermatol"},{"issue":"39","key":"ref_2","first-page":"108","article-title":"Hidradenitis suppurativa; abscess of the apocrine sweat glands","volume":"1939","author":"Brunsting, H.A.","unstructured":"Brunsting HA. Hidradenitis suppurativa; abscess of the apocrine sweat glands. Arch Dermatol 1939;39:108-20.","journal-title":"Arch Dermatol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1097\/00007611-197002000-00006","article-title":"Follicular occlusion triad","volume":"63","author":"Self, S.J.; Montes, L.F.","year":"1970","unstructured":"Self SJ, Montes LF. Follicular occlusion triad. South Med J 1970;63:156-60.","journal-title":"South Med J"},{"key":"ref_4","first-page":"339","article-title":"Hidradenitis suppurativa: a closer look","volume":"70","author":"Gordon, S.W.","year":"1978","unstructured":"Gordon SW. Hidradenitis suppurativa: a closer look. J Natl Med Assoc 1978;70:339-43.","journal-title":"J Natl Med Assoc"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/BF02627258","article-title":"Clinical review of hidradenitis suppurativa. Management of cases with severe perianal involvement","volume":"8","author":"Ching CC, Stahlgren LH","year":"1965","unstructured":"Ching CC, Stahlgren LH. Clinical review of hidradenitis suppurativa. Management of cases with severe perianal involvement. Dis Colon Rectum 1965;8:349-52.","journal-title":"Dis Colon Rectum"},{"issue":"100","key":"ref_6","first-page":"59","article-title":"Squamous cell carcinoma arising in hidradenitis suppurativum","volume":"1969","author":"Humphrey, L.J.; Playforth, H.; Leavell, U.W.","unstructured":"Humphrey LJ, Playforth H, Leavell UW, et al. Squamous cell carcinoma arising in hidradenitis suppurativum. Arch Dermatol 1969;100:59-62.","journal-title":"Arch Dermatol"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"520","DOI":"10.7326\/0003-4819-97-4-520","article-title":"Spondyloarthropathy association with hidradenitis suppurativa and acne conglobata","volume":"97","author":"Rosner, I.A.; Richter, D.E.; Huettner, T.L.","year":"1982","unstructured":"Rosner IA, Richter DE, Huettner TL. Spondyloarthropathy association with hidradenitis suppurativa and acne conglobata. Ann Intern Med 1982;97:520-5.","journal-title":"Ann Intern Med"},{"key":"ref_8","article-title":"Treatment of pyodermas (common pus-forming infections of the skin. In: The 1950 yearbook of dermatology and syphilology","author":"Sulzberger, M.D.; Baer, R.L.","unstructured":"Sulzberger MD, Baer RL. Treatment of pyodermas (common pus-forming infections of the skin. In: The 1950 yearbook of dermatology and syphilology. Chicago: Yearbook Medical Publishers, 1951:46."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1001\/archderm.1977.01640040058008","article-title":"Host-defense mechanisms in hidradenitis suppurativa","volume":"113","author":"Dvorak, V.C.; Root, R.K.; MacGregor, R.R.","year":"1977","unstructured":"Dvorak VC, Root RK, MacGregor RR. Host-defense mechanisms in hidradenitis suppurativa. Arch Dermatol 1977;113:450-3.","journal-title":"Arch Dermatol"},{"issue":"203","key":"ref_10","first-page":"19","article-title":"Hidradenitis suppurativa","volume":"1968","author":"Knaysi, G.A.; Cosman, B.; Crikelair, G.F.","unstructured":"Knaysi GA, Cosman B, Crikelair GF. Hidradenitis suppurativa. JAMA 1968;203:19-22.","journal-title":"JAMA"},{"key":"ref_11","article-title":"Inherited abnormalities of the skin and its appendages","author":"Cockayne, E.A.","unstructured":"Cockayne EA. Inherited abnormalities of the skin and its appendages. London: Oxford University Press, 1933:351."},{"issue":"26","key":"ref_12","first-page":"456","article-title":"Acne vulgaris: heredity in the etiologic background","volume":"1932","author":"Stokes, J.H.; King, A.D.","unstructured":"Stokes JH, King AD. Acne vulgaris: heredity in the etiologic background. 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