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Based on this finding and previous studies, which have shown that beta thalassaemia screening by the osmotic fragility test may miss a significant proportion of beta thalassaemia heterozygotes, we conclude that beta thalassaemia screening in a population in which both alpha and beta thalassaemia are prevalent should combine the one tube osmotic fragility test with electronic measurement of red blood cell indices in the initial screening process.<\/jats:p>","DOI":"10.1136\/jmg.22.5.374","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T15:09:16Z","timestamp":1226329756000},"page":"374-376","source":"Crossref","is-referenced-by-count":6,"title":["Osmotic fragility test in heterozygotes for alpha and beta thalassaemia."],"prefix":"10.1136","volume":"22","author":[{"given":"L","family":"Maccioni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1985,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1056\/NEJM197302152880706","article-title":"Screening for thalassemia trait by electronic measurement of mean corpuscular volume","volume":"288","author":"Pearson, H.A.; O'Brien, R.T.; McIntosh, S.","year":"1973","unstructured":"Pearson HA, O'Brien RT, McIntosh S. 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