{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T19:24:26Z","timestamp":1766690666299,"version":"build-2065373602"},"reference-count":8,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1986,10]]},"abstract":"<jats:p>A population study has been carried out among schoolchildren in the City of Coventry in order to ascertain the frequency of mental retardation associated with the fragile X chromosome. The prevalence of the fragile X mental retardation syndrome in the 11 to 16 year age group (the age of greatest ascertainment) was about 1.0 per 1,000 and therefore indicates that the syndrome is a major cause of mental retardation.<\/jats:p>","DOI":"10.1136\/jmg.23.5.396","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T15:09:16Z","timestamp":1226329756000},"page":"396-399","source":"Crossref","is-referenced-by-count":91,"title":["The frequency of the fragile X chromosome among schoolchildren in Coventry."],"prefix":"10.1136","volume":"23","author":[{"given":"T P","family":"Webb","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Bundey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Thake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Todd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1986,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/ajmg.1320140413","article-title":"The diagnosis and frequency of X-linked conditions in a cohort of moderately retarded males with affected brothers","volume":"14","author":"Fishburn, J.; Turner, G.; Daniel, A.; Brookwell, R.","year":"1983","unstructured":"Fishburn J, Turner G, Daniel A, Brookwell R. The diagnosis and frequency of X-linked conditions in a cohort of moderately retarded males with affected brothers. Am J Med Genet 1983;14:713-24.","journal-title":"Am J Med Genet"},{"key":"ref_2","first-page":"\"461","article-title":"The frequency in British Columbia","volume":"7","author":"Blomquist, H.K.; Gustavson, K.H.; Holmgren, G.; Nordenson, I.; Palsson-Strae, U.","year":"1980","unstructured":"The frequency in British Columbia. Am J Med Genet 1980;7:461-9. Blomquist HK, Gustavson KH, Holmgren G, Nordenson I, Palsson-Strae U. Fragile X syndrome in mildly mentally retarded children in a Northern Swedish county. A prevalence study. Clin Genet 1983;24:393-8.","journal-title":"Am J Med Genet; Fragile X syndrome in mildly mentally retarded children in a Northern Swedish county. A prevalence study"},{"key":"ref_3","first-page":"\"125","article-title":"Factors affecting expression in lymphocyte culture","volume":"31","author":"Bundey, S.; Webb, T.P.; Thake, A.; Todd, J.","year":"1979","unstructured":"Factors affecting expression in lymphocyte culture. Amz J Huni Genet 1979;31:125-35. Bundey S, Webb TP, Thake A, Todd J. A community study of severe mental retardation in the West Midlands and the importance of the fraigile X chromosome in its aetiology. J Med Genet 1985;22:258-66.","journal-title":"Amz J Huni Genet; A community study of severe mental retardation in the West Midlands and the importance of the fraigile X chromosome in its aetiology"},{"key":"ref_4","first-page":"662","article-title":"Heterozygous expression of X-linked mental retardation and Xchromosome marker fra(XXq27f N","volume":"303","author":"R, Turner G.Brookwell; M, Daniel A.Selikowitz M.Zilibowitz","year":"1980","unstructured":"Turner G. Brookwell R, Daniel A. Selikowitz M. Zilibowitz M. Heterozygous expression of X-linked mental retardation and Xchromosome marker fra(XXq27f N EngI J Med 1980:303:662-4. Annual Abstracts of Statistics, 1981-1984. The Central Statistical and Research Unit. West Midlands County Council.","journal-title":"EngI J Med; Annual Abstracts of Statistics, 1981-1984"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1136\/jmg.23.5.400","article-title":"Twelve families with fragile Xq27","volume":"23","author":"Webb, T.; Thake, A.; Todd, J.","year":"1986","unstructured":"Webb T, Thake A, Todd J. Twelve families with fragile Xq27. J Med Genet 1986;23:400-6.","journal-title":"J Med Genet"},{"key":"ref_6","first-page":"153","article-title":"Heritable fragile sites on human chromosomes. XII. Population cytogenetics","volume":"49","author":"Sutherland, G.R.","year":"1985","unstructured":"Sutherland GR. Heritable fragile sites on human chromosomes. XII. Population cytogenetics. Ann Hun,pi Genet 1985:49:153-61."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1469-1809.1984.tb00830.x","article-title":"The marker (X) syndrome: a cytogenetic and genetic analysis","volume":"48","author":"Sherman, S.L.; Morton, N.E.; Jacobs, P.A.; Turner, G.","year":"1984","unstructured":"Sherman SL, Morton NE, Jacobs PA, Turner G. The marker (X) syndrome: a cytogenetic and genetic analysis. Ann Hniiii Genet 1984;48:21-7.","journal-title":"Ann Hniiii Genet"},{"key":"ref_8","first-page":"131","article-title":"Prenatal diagnosis of X-linked mental retardation with fragile (X) using fetoscopy and fetal blood sampling","volume-title":"Prenat Diag","volume":"3","author":"CH, Webb T.Gosden C.M.Rodeck; MA, Hamill; PE, Eason","year":"1983","unstructured":"Webb T. Gosden CM. Rodeck CH, Hamill MA, Eason PE. Prenatal diagnosis of X-linked mental retardation with fragile (X) using fetoscopy and fetal blood sampling. Prenat Diag 1983;3:131-7."}],"container-title":["Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jmg.23.5.396","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T18:32:07Z","timestamp":1760725927000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmg.bmj.com\/lookup\/doi\/10.1136\/jmg.23.5.396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,10]]},"references-count":8,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1986,10,1]]},"published-print":{"date-parts":[[1986,10]]}},"alternative-id":["10.1136\/jmg.23.5.396"],"URL":"https:\/\/doi.org\/10.1136\/jmg.23.5.396","relation":{},"ISSN":["0022-2593","1468-6244"],"issn-type":[{"type":"print","value":"0022-2593"},{"type":"electronic","value":"1468-6244"}],"subject":[],"published":{"date-parts":[[1986,10]]}}}