{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:15:11Z","timestamp":1760832911834,"version":"build-2065373602"},"reference-count":27,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1986,12]]},"abstract":"<jats:p>We have studied the inheritance of four cloned DNA sequences which recognise restriction fragment length polymorphisms on the short arm of the X chromosome in families with Becker and Duchenne muscular dystrophy. We have confirmed linkage of two probe loci to the disease loci and have combined our results with those previously published to give a maximum lod score of 11.642 at a recombination fraction of 0.15 for DXS41 (probe 99.6), and a maximum lod of 15.84 at a recombination fraction of 0.15 for DXS84 (probe 754). Linkage of these diseases to the loci defined by the pERT87 probes and probe pXJ1.1 has also been studied, giving maximum lod scores of 8.634 and 5.118 at recombination fractions of 0.02 and 0.00 respectively. The information obtained using these polymorphic DNA markers, combined with pedigree and CK data, can be used to give more accurate genetic counselling to women at risk in Becker and Duchenne families.<\/jats:p>","DOI":"10.1136\/jmg.23.6.538","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T15:09:16Z","timestamp":1226329756000},"page":"538-547","source":"Crossref","is-referenced-by-count":14,"title":["Linkage studies in Duchenne and Becker muscular dystrophies."],"prefix":"10.1136","volume":"23","author":[{"given":"A","family":"Walker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Hart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Cole","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Hodgson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Dubowitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Bobrow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1986,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/oxfordjournals.bmb.a071623","article-title":"Clinical features and classification of the muscular dystrophies","volume":"36","author":"Gardner-Medwin, D.","year":"1980","unstructured":"Gardner-Medwin D. Clinical features and classification of the muscular dystrophies. Br Med Bull 1980;36:109-15.","journal-title":"Br Med Bull"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1136\/jmg.18.6.442","article-title":"Translocation (X; 6) in a female with Duchenne muscular dystrophy: implications for the localisation of the DMD locus","volume":"18","author":"Zatz, M.; Vianna-Morgante, A.M.; Diament, Campos P.; A.J.","year":"1981","unstructured":"Zatz M, Vianna-Morgante AM, Campos P. Diament AJ. Translocation (X;6) in a female with Duchenne muscular dystrophy: implications for the localisation of the DMD locus. J Med Genet 1981;18:442-7.","journal-title":"J Med Genet"},{"key":"ref_3","first-page":"4613","article-title":"Further evidence for Xp2l location of Duchenne muscular dystrophy (DMD) locus: X; 9 translocation in a female with DMD","volume":"20","author":"Emanuel, B.S.; Zackai, E.H.; Tucker, S.","year":"1983","unstructured":"Emanuel BS, Zackai EH, Tucker S. Further evidence for Xp2l location of Duchenne muscular dystrophy (DMD) locus: X;9 translocation in a female with DMD. J Med Genet 1983;20:4613.","journal-title":"J Med Genet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/300069a0","article-title":"Linkage relationship of a cloned DNA sequence on the short arm of the X-chromosome to Duchenne muscular dystrophy","volume":"300","author":"Murray, J.M.; Davies, K.E.; Harper, P.S.; Meredith, L.; Mueller, C.R.; Williamson, R.","year":"1982","unstructured":"Murray JM, Davies KE, Harper PS, Meredith L, Mueller CR, Williamson R. Linkage relationship of a cloned DNA sequence on the short arm of the X-chromosome to Duchenne muscular dystrophy. Nature 1982;300:69-71.","journal-title":"Nature"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1093\/nar\/11.8.2303","article-title":"Linkage analysis of two cloned DNA sequences flanking the Duchenne muscular dystrophy locus on the short arm of the human X-chromosome","volume":"11","author":"Davies, K.E.; Pearson, P.L.; Harper, P.S.","year":"1983","unstructured":"Davies KE, Pearson PL, Harper PS, et al. Linkage analysis of two cloned DNA sequences flanking the Duchenne muscular dystrophy locus on the short arm of the human X-chromosome. Nucleic Acids Res 1983;11:2303-12.","journal-title":"Nucleic Acids Res"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/BF00283362","article-title":"Segregation analysis of a marker localised Xp2l-2-Xp213 in Duchenne and Becker muscular dystrophy families","volume":"71","author":"Dorkins, H.; Junien, C.; Mandel, J.L.","year":"1985","unstructured":"Dorkins H, Junien C, Mandel JL, et al. Segregation analysis of a marker localised Xp2l-2-Xp213 in Duchenne and Becker muscular dystrophy families. Hum Genet 1985;71:103-7.","journal-title":"Hum Genet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/BF00273073","article-title":"Isolation of probes detecting restriction fragment length polymorphisms from X chromosome specific libraries: potential use for diagnosis of Duchenne muscular dystrophy","volume":"70","author":"Hofker, M.H.; Wapenaar, M.C.; Bakker, Goor N.; B, Van Ommen; GJB, Pearson; P.L.","year":"1985","unstructured":"Hofker MH, Wapenaar MC, Goor N. Bakker B, Van Ommen GJB, Pearson PL. Isolation of probes detecting restriction fragment length polymorphisms from X chromosome specific libraries: potential use for diagnosis of Duchenne muscular dystrophy. Hum Genet 1985;70:148-56.","journal-title":"Hum Genet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/BF00295379","article-title":"Multipoint linkage analysis of the short arm of the human X chromosome in families with X-linked muscular dystrophy","volume":"70","author":"Wilcox, D.E.; Yates, Affara N.A.; JRW, Ferguson-Smith; MA, Pearson; P.L.","year":"1985","unstructured":"Wilcox DE, Affara NA. Yates JRW, Ferguson-Smith MA, Pearson PL. Multipoint linkage analysis of the short arm of the human X chromosome in families with X-linked muscular dystrophy. Hum Genet 1985;70:365-75.","journal-title":"Hum Genet"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1093\/nar\/13.10.3419","article-title":"Human X chromosome markers and Duchenne muscular dystrophy","volume":"13","author":"Davies, K.E.; Speer, A.; Herrmann, F.","year":"1985","unstructured":"Davies KE, Speer A, Herrmann F. et al. Human X chromosome markers and Duchenne muscular dystrophy. Nucleic Acids Res 1985;13:3419-26.","journal-title":"Nucleic Acids Res"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/BF00295671","article-title":"Genetic linkage relationships of seven DNA probes with Duchenne and Becker muscular dystrophy","volume":"71","author":"Brown, C.S.; Thomas, N.S.T.; Sarfarazi, M.","year":"1985","unstructured":"Brown CS, Thomas NST, Sarfarazi M, et al. Genetic linkage relationships of seven DNA probes with Duchenne and Becker muscular dystrophy. Hum Genet 1985;71:62-74.","journal-title":"Hum Genet"},{"issue":"32","key":"ref_11","first-page":"261","article-title":"The linkage relationships of the loci for benign (Becker type) X-borne muscular dystrophy, colour blindness and the Xg blood groups","volume":"1969","author":"Emery, A.E.H.; Smith, C.A.B.; Sanger, R.","unstructured":"Emery AEH, Smith CAB, Sanger R. 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The use of flanking markers in prediction for Duchenne muscular dystrophy. Arch Dis Child 1986;61:218-22.","journal-title":"Arch Dis Child"}],"container-title":["Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jmg.23.6.538","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T06:27:18Z","timestamp":1760768838000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmg.bmj.com\/lookup\/doi\/10.1136\/jmg.23.6.538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,12]]},"references-count":27,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1986,12,1]]},"published-print":{"date-parts":[[1986,12]]}},"alternative-id":["10.1136\/jmg.23.6.538"],"URL":"https:\/\/doi.org\/10.1136\/jmg.23.6.538","relation":{},"ISSN":["0022-2593","1468-6244"],"issn-type":[{"type":"print","value":"0022-2593"},{"type":"electronic","value":"1468-6244"}],"subject":[],"published":{"date-parts":[[1986,12]]}}}