{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:11:27Z","timestamp":1760955087175,"version":"build-2065373602"},"reference-count":6,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1986,12]]},"abstract":"<jats:p>Linkage studies have been carried out in 20 families segregating for Duchenne muscular dystrophy and eight prenatal diagnoses performed, including six first trimester diagnoses and one twin pregnancy. The results of the restriction fragment length polymorphism (RFLP) analysis suggest that not all the possible RFLPs need to be used and a strategy for carrier detection studies is proposed.<\/jats:p>","DOI":"10.1136\/jmg.23.6.556","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T15:09:16Z","timestamp":1226329756000},"page":"556-559","source":"Crossref","is-referenced-by-count":12,"title":["Prenatal diagnosis of Duchenne muscular dystrophy by DNA analysis."],"prefix":"10.1136","volume":"23","author":[{"given":"J M","family":"Old","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K E","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1986,12,1]]},"reference":[{"key":"ref_1","article-title":"A strategy for construction of highly polymorphic DNA haplotypes in specific human chromosomal regions: application to linkage analysis of X chromosome specific diseases such as Duchenne mnuscular dystrophy","volume":"1984","author":"S, Aldridge J.KLinkel L.Bruns G.Lalande M.Tantravahi U.Latt","unstructured":"Aldridge J. KLinkel L. Bruns G. Lalande M. Tantravahi U. Latt S. A strategy for construction of highly polymorphic DNA haplotypes in specific human chromosomal regions: application to linkage analysis of X chromosome specific diseases such as Duchenne mnuscular dystrophy. I\/alJ Neurol Sci 1984:3:39 46. ' Bakker E. Hofker MH. Goor N. et al. Prenatal diagnosis and carrier detection of Duchenne muscular dystrophy with closely linked RFLPs. Lancet 1985Xi:655 8.","journal-title":"I\/alJ Neurol Sci; 3: 39 46. ' Bakker E. Hofker MH"},{"issue":"243 9","key":"ref_2","article-title":"Molecular genetics of the human X chromosome","volume":"22","author":"Davies, K.E.","unstructured":"Davies KE. Molecular genetics of the human X chromosome. J Med Genet 1985:22:243 9.","journal-title":"J Med Genet"},{"issue":"842 5","key":"ref_3","article-title":"Detection of deletions spanning the DUchenne muscular dystrophy locus using a tightly linked DNA segment","volume":"316","author":"W, Monaco A.P.Bertelson C.J.Middlesworth; ef al","unstructured":"Monaco AP. Bertelson CJ. Middlesworth W, ef al. Detection of deletions spanning the DUchenne muscular dystrophy locus using a tightly linked DNA segment. Nalurc 1985,316:842 5.","journal-title":"Nalurc"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1159\/000132178","article-title":"Report of the committee on the genetic constitution of the X and Y chromosome","volume":"40","author":"Goodfellow, P.; Davies, K.E.; Ropers, H.H.","year":"1985","unstructured":"Goodfellow P, Davies KE, Ropers HH. Report of the committee on the genetic constitution of the X and Y chromosome. Human Gene Mapping 8. Cytogenet Cell Genet 1985;40:296-352.","journal-title":"Human Gene Mapping 8. Cytogenet Cell Genet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/322073a0","article-title":"Analysis of deletions in DNA from patients with Becker and Duchenne muscular dystrophy","volume":"322","author":"Kunkel, L.M.; Hejtmancik, J.F.; Caskey, C.T.","year":"1986","unstructured":"Kunkel LM, Hejtmancik JF, Caskey CT, et al. Analysis of deletions in DNA from patients with Becker and Duchenne muscular dystrophy. Nature 1986;322:73-7.","journal-title":"Nature"},{"key":"ref_6","first-page":"1","article-title":"Fetal DNA analysis","volume-title":"Analysis of human genetic diseases","author":"Old, J.M.","year":"1986","unstructured":"Old JM. Fetal DNA analysis. In: Davies KE, ed. Analysis of human genetic diseases. Oxford: IRL Press, 1986: 1-15."}],"container-title":["Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jmg.23.6.556","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T18:52:45Z","timestamp":1760727165000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmg.bmj.com\/lookup\/doi\/10.1136\/jmg.23.6.556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,12]]},"references-count":6,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1986,12,1]]},"published-print":{"date-parts":[[1986,12]]}},"alternative-id":["10.1136\/jmg.23.6.556"],"URL":"https:\/\/doi.org\/10.1136\/jmg.23.6.556","relation":{},"ISSN":["0022-2593","1468-6244"],"issn-type":[{"type":"print","value":"0022-2593"},{"type":"electronic","value":"1468-6244"}],"subject":[],"published":{"date-parts":[[1986,12]]}}}