{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:26:41Z","timestamp":1782487601163,"version":"3.54.5"},"reference-count":11,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1987,10]]},"abstract":"<jats:p>A large scale survey of haemoglobinopathies and thalassaemia has been carried out in China, involving 900,000 people in 28 provinces. It has resulted in the finding of many new variants and some interesting cases of thalassaemia, and in a study on the chemical structure of abnormal haemoglobins and DNA analysis of thalassaemia. We report here data on haemoglobin disorders in the Chinese, mainly the characterisation of the geographical distribution of haemoglobin variants, the analysis of globin genes of alpha, beta, gamma, or delta beta thalassaemia, and the progress in prenatal diagnosis of alpha and beta thalassaemia conducted in the authors' laboratory.<\/jats:p>","DOI":"10.1136\/jmg.24.10.578","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T15:09:16Z","timestamp":1226329756000},"page":"578-583","source":"Crossref","is-referenced-by-count":78,"title":["Disorders of haemoglobin in China."],"prefix":"10.1136","volume":"24","author":[{"given":"Y T","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S Z","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1987,10,1]]},"reference":[{"key":"ref_1","first-page":"382","article-title":"China Hemoglobinopathy Cooperative Study Group. A survey of hemoglobinopathy in 600,000 people of 20 provinces, cities and autonomous regions of China","volume":"63","year":"1983","unstructured":"China Hemoglobinopathy Cooperative Study Group. A survey of hemoglobinopathy in 600,000 people of 20 provinces, cities and autonomous regions of China. Nat! Med J China 1983;63:382-5.","journal-title":"Nat! Med J China"},{"key":"ref_2","first-page":"462","article-title":"Hematology of the Chinese Academy of Medical Sciences. Epidemiologic analysis of abnormal hemoglobins in China","volume":"66","author":"Institute of","year":"1986","unstructured":"Institute of Hematology of the Chinese Academy of Medical Sciences. Epidemiologic analysis of abnormal hemoglobins in China. Natl Med J China 1986;66:462-4.","journal-title":"Natl Med J China"},{"key":"ref_3","first-page":"2","article-title":"Study on abnormal hemoglobin in China","volume":"6","author":"Bang-zhe, Ren","year":"1986","unstructured":"Ren Bang-zhe. 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Acta Genet Sinica 1986;13:317-22.","journal-title":"Acta Genet Sinica"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00295521","article-title":"DNA polymorphism and molecular pathology of the human globin gene cluster","volume":"69","author":"Antonarakis, S.E.; HH, Jr, Kazazian; Orkin, S.H.","year":"1985","unstructured":"Antonarakis SE, Kazazian HH Jr, Orkin SH. DNA polymorphism and molecular pathology of the human globin gene cluster. Hum Genet 1985;69:1-14.","journal-title":"Hum Genet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1073\/pnas.81.9.2821","article-title":"j3-thalassemia in Chinese: use of in vivo RNA analysis and oligonucleotide hybridization in systematic characterization of molecular defects","volume":"81","author":"Cheng, T.C.; Orkin, S.H.; Antonarakis, S.E.","year":"1984","unstructured":"Cheng TC, Orkin SH, Antonarakis SE, et al. j3-thalassemia in Chinese: use of in vivo RNA analysis and oligonucleotide hybridization in systematic characterization of molecular defects. 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Abstract (M IV.31) 7th International Congress of Human Genetics, Berlin, September, 1986. \"' Zeng YT, Huang SZ, Sheng M, et al. Prenatal diagnosis of,1thalassemia. Shanghai Med J 1985;8:559-64.","journal-title":"Sheng M, et al. Prenatal diagnosis of,1thalassemia. Shanghai Med J; Zeng YT, Huang SZ"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/ajh.2830180303","article-title":"-GyAythalassemia and y-chain variants in Chinese newborn babies","volume":"18","author":"Zeng, Y.T.; Huang, S.Z.; Nakatsuji, T.; Huisman, T.H.J.","year":"1985","unstructured":"Zeng YT, Huang SZ, Nakatsuji T, Huisman THJ. -GyAythalassemia and y-chain variants in Chinese newborn babies. Am J Hematol 1985;18:235-42.","journal-title":"Am J Hematol"},{"key":"ref_11","first-page":"1430","article-title":"Hereditary persistence of fetal hemoglobin or","volume":"66","author":"Zeng, Y.T.; Huang, S.Z.; Chen, B.","year":"1985","unstructured":"Zeng YT, Huang SZ, Chen B, et al. Hereditary persistence of fetal hemoglobin or (6f)'-thalassemia: three types observed in South Chinese family. Blood 1985;66:1430-4.","journal-title":"Blood; three types observed in South Chinese family"}],"container-title":["Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jmg.24.10.578","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T06:46:33Z","timestamp":1760769993000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmg.bmj.com\/lookup\/doi\/10.1136\/jmg.24.10.578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,10]]},"references-count":11,"journal-issue":{"issue":"10","published-online":{"date-parts":[[1987,10,1]]},"published-print":{"date-parts":[[1987,10]]}},"alternative-id":["10.1136\/jmg.24.10.578"],"URL":"https:\/\/doi.org\/10.1136\/jmg.24.10.578","relation":{},"ISSN":["0022-2593","1468-6244"],"issn-type":[{"value":"0022-2593","type":"print"},{"value":"1468-6244","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,10]]}}}