{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T22:52:49Z","timestamp":1770591169682,"version":"3.49.0"},"reference-count":7,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1987,11]]},"abstract":"<jats:p>Four infants who were exposed to sodium valproate or valproic acid during pregnancy are described. Common facial features in the three surviving infants include epicanthic folds, a flat nasal bridge, a broad nasal base, anteverted nostrils, a shallow philtrum, and a thin upper lip with a thick lower lip. Ridging of the metopic suture, congenital heart defect, postaxial polydactyly, and hypospadias were additional features in individual cases. In agreement with previous authors, we feel that there is a distinctive 'fetal valproate' phenotype.<\/jats:p>","DOI":"10.1136\/jmg.24.11.692","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T15:09:16Z","timestamp":1226329756000},"page":"692-695","source":"Crossref","is-referenced-by-count":80,"title":["Fetal valproate syndrome: is there a recognisable phenotype?"],"prefix":"10.1136","volume":"24","author":[{"given":"R M","family":"Winter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Donnai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Burn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S M","family":"Tucker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1987,11,1]]},"reference":[{"issue":"99","key":"ref_1","first-page":"28","article-title":"Ga ILIMC.1. Tcr-aboo9nicitv ot ailpl-oic ai'cCdidIJ PPe\/di{iorla1I9t8)().0(9; 77: .3.32'_3. - Clav SA. NI1cVic R. Cthcn 11. Possihlc tcratogciicic ctOccit ot valproic acid","volume":"1981","author":"J, Datlcns B.Raynmd E.","unstructured":"Datlcns B. Raynmd E.J. Ga ILIMC.1. Tcr-aboo9nicitv ot ailpl-oic ai'cCdidIJ PPe\/di{iorla1I9t8)().0(9;77:.3.32'_3. - Clav SA. NI1cVic R. Cthcn 11. Possihlc tcratogciicic ctOccit ot valproic acid. J PeidtrI 1981:99:28.","journal-title":"J PeidtrI"},{"key":"ref_2","first-page":"163","article-title":"B3LchiMnI N I'Cr-ltolciccI'IIoC tt t anlticonVUlsants..1 I'edloot","volume":"99","author":"D, X.Thoma'is","year":"1981","unstructured":";98:508--9. X Thoma'.is D. B3LchiMnI N I'Cr-ltolciccI'IIoC tt t anlticonVUlsants..1 I'edloot 1981:99:163."},{"key":"ref_3","first-page":"10","article-title":"lcIgc I1 Possihic tcratogcnic cItcct ol valprotIc dLring pr1c\"l nancv.\/ d\/adiatr 1983: 103","author":"lRonian E. Ratinz D, Koch S.Jacr","unstructured":"Koch S. Jacr lRonian E. Ratinz D. lcIgc I1 Possihic tcratogcnic cItcct ol valprotIc dLring pr1c\"l nancv.\/ d\/adiatr 1983:103:10((7-."},{"key":"ref_4","first-page":"937","article-title":"Guihaud 1. Matcrnal valpi-poilc aicii andic congcnilita ncLirall tuhc dcf'ccts","volume":"1982","author":"Rohcrt, E.","unstructured":"Rohcrt E. Guihaud 1. Matcrnal valpi-poilc aicii andic congcnilita ncLirall tuhc dcf'ccts. L.ance 1982:ii:937. fBjcrkcdal T. (Czcizcl A. Gotjarc.l1. et t\/l. vailroic aicidi and'spinla hitiida. Lancet 1982:ii: 1096.","journal-title":"L.ance; Gotjarc.l1. et t\/l. vailroic aicidi and'spinla hitiida"},{"key":"ref_5","first-page":"1282","article-title":"Sodium valproatc and ncural tubc dcfccts","volume":"ii:","author":"Jeavons, P.M.","year":"1982","unstructured":"Jeavons PM. Sodium valproatc and ncural tubc dcfccts. Lancet 1982 ii: 1282-3.","journal-title":"Lancet"},{"key":"ref_6","first-page":"473","article-title":"Thc cital valproatc syndromc. Amii J 'led","volume":"19","author":"CJR, DiLihcrti J.H.I.Fcrndon P.A.Dcniniis N.R.Cuirri","year":"1984","unstructured":"DiLihcrti JHI. Fcrndon PA. Dcniniis NR. Cuirri CJR. Thc cital valproatc syndromc. Amii J 'led (Ceticiw 1984:19:473-81. Tcini 1."},{"key":"ref_7","first-page":"291","article-title":"Possibic valpr-oatc tcratoocnicitv Arch\/,'eurol 1985: 42","author":"MacGicgor, D.L.","unstructured":"MacGicgor DL. Possibic valpr-oatc tcratoocnicitv Arch\/,'eurol 1985:42:291-3."}],"container-title":["Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jmg.24.11.692","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T04:59:33Z","timestamp":1759726773000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmg.bmj.com\/lookup\/doi\/10.1136\/jmg.24.11.692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,11]]},"references-count":7,"journal-issue":{"issue":"11","published-online":{"date-parts":[[1987,11,1]]},"published-print":{"date-parts":[[1987,11]]}},"alternative-id":["10.1136\/jmg.24.11.692"],"URL":"https:\/\/doi.org\/10.1136\/jmg.24.11.692","relation":{},"ISSN":["0022-2593","1468-6244"],"issn-type":[{"value":"0022-2593","type":"print"},{"value":"1468-6244","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,11]]}}}