{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T19:14:08Z","timestamp":1760728448042,"version":"build-2065373602"},"reference-count":11,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1987,4]]},"abstract":"<jats:p>The outcome of four successive pregnancies in a woman heterozygous for X linked hydrocephalus is described. The last two were scanned by ultrasound. In one, a good prognosis was given; the fetus was male but there was no evidence of dilated cerebral ventricles. In the other, hydrocephalus was diagnosed. The absence of aqueductal stenosis in this case supports the hypothesis that in this X linked condition communicating hydrocephalus is the primary defect and aqueductal stenosis is secondary.<\/jats:p>","DOI":"10.1136\/jmg.24.4.207","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T15:09:16Z","timestamp":1226329756000},"page":"207-209","source":"Crossref","is-referenced-by-count":18,"title":["Prenatal diagnosis of X linked hydrocephalus without aqueductal stenosis."],"prefix":"10.1136","volume":"24","author":[{"given":"V","family":"V\u00e1radi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Cs\u00e9csei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G T","family":"Szeifert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z","family":"T\u00f3th","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z","family":"Papp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1987,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1093\/brain\/72.2.246","article-title":"Hereditary stenosis of the aqueduct of Sylvius as a cause of congenital hydrocephaly","volume":"72","author":"Bickers, D.S.; Adams, R.D.","year":"1949","unstructured":"Bickers DS, Adams RD. Hereditary stenosis of the aqueduct of Sylvius as a cause of congenital hydrocephaly. Brain 1949;72: 246-62.","journal-title":"Brain"},{"issue":"36","key":"ref_2","first-page":"481","article-title":"Sex-linked hydrocephalus. Report of a family with 15 affected members","volume":"1961","author":"Edwards, J.H.; Norman, R.M.; Roberts, J.M.","unstructured":"Edwards JH, Norman RM, Roberts JM. Sex-linked hydrocephalus. Report of a family with 15 affected members. Arch Dis Child 1961;36:481-5.","journal-title":"Arch Dis Child"},{"issue":"36","key":"ref_3","first-page":"486","article-title":"The syndrome of sex-linked hydrocephalus","volume":"1961","author":"Edwards, J.H.","unstructured":"Edwards JH. The syndrome of sex-linked hydrocephalus. Arch Dis Child 1961;36:486-93.","journal-title":"Arch Dis Child"},{"key":"ref_4","first-page":"48","article-title":"Mental retardation and congenital malformations of the central nervous system","author":"Warkany, J.; Lemire, R.J.; Cohen, M.M.","year":"1981","unstructured":"Warkany J, Lemire RJ, Cohen MM. Mental retardation and congenital malformations of the central nervous system. Chicago: Year Book Medical Publishers, 1981;48-82."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1136\/jmg.14.1.72","article-title":"Sex-linked hydrocephalus","volume":"14","author":"Cassie, R.; Boon, A.R.","year":"1977","unstructured":"Cassie R, Boon AR. Sex-linked hydrocephalus. J Med Genet 1977;14:72-3.","journal-title":"J Med Genet"},{"key":"ref_6","first-page":"245","article-title":"X-linked aqueductal stenosis. Clin Genet 1977; 11: 416-20. ' Van Egmond-Linden","volume-title":"Prenatal diagnosis of Xlinked hydrocephaly","volume":"3","author":"Sovik 0, van der Hagen CB, Loken AC","year":"1983","unstructured":"Sovik 0, van der Hagen CB, Loken AC. X-linked aqueductal stenosis. Clin Genet 1977;11:416-20. ' Van Egmond-Linden A, Wladimiroff JW, Jahoda MGJ, Niermeijer MF, Sachs ES, Stefanko S. Prenatal diagnosis of Xlinked hydrocephaly. Prenat Diag 1983;3:245-8."},{"key":"ref_7","first-page":"168","article-title":"Sex-linked hydrocephalus with severe mental defect","volume":"i:","author":"Editorial","year":"1962","unstructured":"Editorial. Sex-linked hydrocephalus with severe mental defect Br Med J 1962;i:168.","journal-title":"Br Med J"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1001\/archneur.1977.00500130038008","article-title":"Pathogenesis of resvirus type I hydrocephalus in mice","volume":"34","author":"Masters, C.; Alpers, M.; Kakulas, B.","year":"1977","unstructured":"Masters C, Alpers M, Kakulas B. Pathogenesis of resvirus type I hydrocephalus in mice. Arch Neurol 1977;34:18-28.","journal-title":"Arch Neurol"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"\"521","DOI":"10.1136\/jnnp.40.6.521","article-title":"Aqueductal stenosis. case review and discussion","volume":"4","author":"McMillan, J.J.; Williams, B.","year":"1977","unstructured":"McMillan JJ, Williams B. Aqueductal stenosis. case review and discussion. J Neurol Neurosurg Psychiatry 1977;4:521-32. l Fandre M, Leroux B, Couchot J, Pennafotte F, Pluot B. Hydrocephalie liee au sexe. A propos de trois families distinctes. Arch Fr Pediatr 1972;29:.778.","journal-title":"J Neurol Neurosurg Psychiatry; Hydrocephalie liee au sexe. A propos de trois families distinctes"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/j.1469-8749.1979.tb01678.x","article-title":"Aqueductal stenosis in X-linked hydrocephalus: a secondary phenomenon?","volume":"21","author":"Landrieu, P.; Ninane, J.; Ferriere, G.; Lyon, G.","year":"1979","unstructured":"Landrieu P, Ninane J, Ferriere G, Lyon G. Aqueductal stenosis in X-linked hydrocephalus: a secondary phenomenon? Dev Med Child Neurol 1979;21:637-42.","journal-title":"Dev Med Child Neurol"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1136\/jmg.17.2.158","article-title":"Prenatal study of X-linked aqueductal stenosis","volume":"17","author":"Benke, P.; Strassberg, R.","year":"1980","unstructured":"Benke P, Strassberg R. Prenatal study of X-linked aqueductal stenosis. J Med Genet 1980;17:158.","journal-title":"J Med Genet"}],"container-title":["Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jmg.24.4.207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T18:28:51Z","timestamp":1760725731000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmg.bmj.com\/lookup\/doi\/10.1136\/jmg.24.4.207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,4]]},"references-count":11,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1987,4,1]]},"published-print":{"date-parts":[[1987,4]]}},"alternative-id":["10.1136\/jmg.24.4.207"],"URL":"https:\/\/doi.org\/10.1136\/jmg.24.4.207","relation":{},"ISSN":["0022-2593","1468-6244"],"issn-type":[{"type":"print","value":"0022-2593"},{"type":"electronic","value":"1468-6244"}],"subject":[],"published":{"date-parts":[[1987,4]]}}}